M.bennett at 00:18, 22 August 2020

2020-08-22T00:18:34Z

M.bennett: Created page with " '''Some poor evidence of..."

2020-08-22T00:11:12Z

Created page with " '''Some poor evidence of..."

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'''Some poor evidence of improvement in measures of cognition in dementia patients with a combination of hyperbaric oxygen and acetazolamide'''

'''Clinical Bottom Line'''

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'''1. Some improvement in cognition following combined treatment with acetazolamide and hyperbaric oxygen which trended back to starting values over 8 weeks. 2. True impacts of either agent difficult to define.'''

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'''Citation/s:'''1.Boyle E, Aparico A, Canosa F, Owen D, Dash HH. Hyperbaric oxygen and acetazolamide in the treatment of senile cognitive functions. In: Trapp WG, Bannister EW, Davison AJ, Trapp PA, eds. Proceedings of the Fifth International Hyperbaric Conference. Burnaby, Canada: Simon Fraser University, 1974:432-438 '''Lead author's name and fax: '''Boyle. Miami Heart Institute Research Division, Miami Beach, Florida

'''Three-part Clinical Question:'''For patients with senile dementia, does the application of either hyperbaric oxygen or acetazolomide result in improved cognition. '''Search Terms:''' Acetazolamide; cognition; dementia

'''The Study:'''Non-blinded randomised controlled trial without intention-to-treat. '''The Study Patients:''' “Aged senile subjects.” '''Control group''' (N = 21; ? analysed): Breathing 13% oxygen at 3 ATA for 30 minutes to a total of 10 sessions over two weeks. '''Experimental group''' (N = 30; ? analysed): As above but breathing 100% oxygen at 3 ATA and given acetazolamide 250mg orally for the same 10 day period.

'''The Evidence:'''

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'''Non-Event Outcomes'''

| style="border:solid windowtext 1.0pt" | '''Time to outcome/s'''
| style="border:solid windowtext 1.0pt" | '''Control group'''
| style="border:solid windowtext 1.0pt" | '''Experimental group'''
| style="border:solid windowtext 1.0pt" | '''P-value'''
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'''Bender-Gestalt Test'''

| style="border:solid windowtext 1.0pt" | 8 weeks
| style="border:solid windowtext 1.0pt" | 120 to 130
| style="border:solid windowtext 1.0pt" | 109 to102
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | ??
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'''Weschler Memory Scale'''

| style="border:solid windowtext 1.0pt" | 8 weeks
| style="border:solid windowtext 1.0pt" | 116 to 125
| style="border:solid windowtext 1.0pt" | 110 to 115
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | ??
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| style="border:solid windowtext 1.0pt" |
'''Reaction time'''

| style="border:solid windowtext 1.0pt" | 8 weeks
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" |  
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" |  
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | ??
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'''Comments:''' 1. Old study poorly conducted and reported by modern standards. 2. Probably an open label study, incomplete randomisation and an undefined number of crossover patients at eight weeks. 3. Results are not easily interpreted given undisclosed drop-outs and interrupted comparisons. 4. No details of the meaning of the numerical outcomes

'''Appraised by:'''Mike Bennett, m.bennett@unsw.edu.au ; Saturday, 22 August 2020 '''Kill or Update By:''' August 2025

Boyle - Revision history

M.bennett at 00:18, 22 August 2020

M.bennett: Created page with " '''Some poor evidence of..."