http://hboevidence.wikis.unsw.edu.au/index.php?action=history&feed=atom&title=Drewry
Drewry - Revision history
2026-10-13T04:55:39Z
Revision history for this page on the wiki
MediaWiki 1.31.0
http://hboevidence.wikis.unsw.edu.au/index.php?title=Drewry&diff=70&oldid=prev
Gordoben: Imported from Wikispaces
2018-11-26T05:33:25Z
<p>Imported from Wikispaces</p>
<p><b>New page</b></p><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 130%;">'''Heliox recompression for the treatment of DCI may result in fewer patients requiring multiple recompressions.''' </span><br />
{| <br />
| <span style="font-family: Arial,Helvetica,sans-serif; font-size: 15px;">'''Clinical Bottom Line:''' </span> <br />
|-<br />
| <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1. Fewer patients in the heliox group required more than one recompression due to incomplete resolution and /or persistence of symptoms. </span> <br />
|-<br />
|}<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Appraised by:''' Mike Bennett, Dept. of Diving and Hyperbaric Medicine, Prince of Wales Hospital </span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Sydney; Monday, 23 November, 1998 </span><br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Clinical Scenario:''' A patient presenting with decompression illness after air diving. </span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Three-part Question:''' In patients suffering with decompression illness, does the application of 50/50 heliox at 2.8 ATA, compared to standard 100% oxygen treatment tables, result in any reduction in the proportion with incomplete resolution and/or return of symptoms? </span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Search Terms:''' Hyperbaric oxygenation, decompression illness. </span><br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study:''' </span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Double-blinded concealed randomised controlled trial intention-to-treat unknown. </span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Recreational air divers with diagnosis of decompression illness. </span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Control group (N = 31; 31 analysed): Recompression on a standard US Navy Table 6 to 2.8ATA with 100% oxygen breathing periods. </span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Experimental group (N = 25; 25 analysed): Recompression to 2.8ATA, but substitution of 50% oxygen, 50%helium as breathing mixture. </span><br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Evidence:''' </span><br />
{| <br />
| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Outcome </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Time to Outcome </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">100% </span>'''</span></span><span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">oxygen </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Heliox </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Relative risk reduction </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Absolute risk reduction </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Number needed to treat </span>'''</span></span> <br />
|-<br />
| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Required multiple recompression </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">1 year </span></span> || <span style'''"display: block; text-align: center;"><span style'''"color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">0.65 </span></span> || <span style'''"display: block; text-align: center;"><span style'''"color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">0.36 </span></span> || <span style'''"display: block; text-align: center;"><span style'''"color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">44% </span></span> || <span style'''"display: block; text-align: center;"><span style'''"color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">0.285 </span></span> || <span style'''"display: block; text-align: center;"><span style="color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">4 </span></span> <br />
|-<br />
| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"color: #000066; font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">95% CI </span>'''</span></span> || || || || <span style'''"display: block; text-align: center;"><span style'''"color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">5% to 83% </span></span> || <span style'''"display: block; text-align: center;"><span style'''"color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">0.03 to 0.54 </span></span> || <span style'''"display: block; text-align: center;"><span style="color: #000066; display: block; font-family: &#39;times new roman&#39;,&#39;serif&#39;; font-size: 16px; text-align: center;">2 to 31 </span></span> <br />
|-<br />
|}<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Comments:'''</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1. 18 of 88 enrolled patients subsequently withdrawn due to protocol breach.</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">2. Interim report only in abstract.</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">3. No results published for absolute rate of treatment success.</span><br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Expiry date:''' December 2021.</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''References:'''</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1. Drewry A, Gorman DF. A progress report on the prospective randomised double blind controlled study of oxygen and oxygen-helium in the treatment of air-diving decompression illness. Undersea and Hyperbaric Medicine Supplement 1994; 21:98. </span><br />
<br />
[[File:sumhorsa.gif|center]]<br />
<span style="display: block; text-align: center;"><br />
<br />
<span style="font-size: 24px;">[[Diving Medicine | BACK]]</span></span><span style="display: block; text-align: center;"><br />
</span></div>
Gordoben