M.bennett at 06:30, 4 January 2023

2023-01-04T06:30:45Z

M.bennett: Created page with " '''The addition of hyper..."

2023-01-04T06:25:52Z

Created page with " '''The addition of hyper..."

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'''The addition of hyperbaric oxygen therapy to a rehabilitation programme for incomplete spinal cord injury improved mood.'''

{| class="Table" style="width: 853px;" width="638"
|- style="height:101.05pt"
| style="width: 841px;" |
'''Clinical Bottom Line:'''

'''1. HBOT improved mood when added to a rehabilitation programme over eight weeks. 2. HBOT seemed similarly effective to psychotherapy, with some minor indication it may be a little better.'''

|}

'''Citation/s:'''1. Feng JJ, Li YH. Effects of hyperbaric oxygen therapy on depression and anxiety in the patients with incomplete spinal cord injury (a STROBE-compliant article). Medicine. 2017 Jul;96(29). '''Lead author's name and fax: '''Juan-Juan Feng kffjj2008@sina.com

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'''Three-part Clinical Question:'''For patients with incomplete spinal cord injury, does the administration of hyperbaric oxygen improve depression and anxiety symptoms?

'''Search Terms:''' Spinal cord injury; anxiety; depression

'''The Study:''' Single-blinded randomised controlled trial with intention-to-treat. '''The Study Patients:''' Patients with traumatic cervical or thoracolumbar SCI with depression and/or anxiety. Time after injury not specified. '''Control group''' (N = 20 ; 20 analysed): Conventional rehabilitation measures including drugs, respiratory training, bladder training, standing exercises etc daily six days each week for 8 weeks. '''Experimental group''' (N = 20 ; 20 analysed): As above plus 100% oxygen breathing at 2.0 ATA for 60 minutes daily, six days each week for 8 weeks.

'''The Evidence:'''

 

{| class="Table" style="border: 1pt solid windowtext; width: 701px;"
|-
| rowspan="2" style="width:188.9pt; border:solid windowtext 1.0pt" width="252" | '''Measure'''
| colspan="2" style="width:83.55pt; border:solid windowtext 1.0pt" width="111" | '''Control Group'''
| colspan="2" style="width:71.95pt; border:solid windowtext 1.0pt" width="96" | '''HBOT Group'''
| rowspan="2" style="width: 85px; border: 1pt solid windowtext;" width="63" | '''Difference'''
| rowspan="2" style="border: 1pt solid windowtext; width: 107px;" | '''95% CI'''
|-
| style="width:41.0pt; border:solid windowtext 1.0pt" width="55" | '''Mean'''
| style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | '''SD'''
| style="width:33.9pt; border:solid windowtext 1.0pt" width="45" | '''Mean'''
| style="width:36.55pt; border:solid windowtext 1.0pt" width="49" | '''SD'''
|-
| style="width:188.9pt; border:solid windowtext 1.0pt" width="252" |
'''Hamilton Depression (HAMD) scale (0 to 96) 8 weeks [lower better]'''

| style="width:41.0pt; border:solid windowtext 1.0pt" width="55" | 8.9
| style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | 1.8
| style="width:33.9pt; border:solid windowtext 1.0pt" width="45" | 13.8
| style="width:36.55pt; border:solid windowtext 1.0pt" width="49" | 2.3
| style="width: 85px; border: 1pt solid windowtext;" width="63" | 4.9
| style="border: 1pt solid windowtext; width: 107px;" | 2.2 to 7.6
|-
| style="width:188.9pt; border:solid windowtext 1.0pt" width="252" |
'''Hamilton Anxiety (HAMA) scale (0 to 56) 8 weeks [lower better]'''

| style="width:41.0pt; border:solid windowtext 1.0pt" width="55" | 9.2
| style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | 1.5
| style="width:33.9pt; border:solid windowtext 1.0pt" width="45" | 11.9
| style="width:36.55pt; border:solid windowtext 1.0pt" width="49" | 2.3
| style="width: 85px; border: 1pt solid windowtext;" width="63" | 2.7
| style="border: 1pt solid windowtext; width: 107px;" | 0.3 to 5.1
|-
| style="width:188.9pt; border:solid windowtext 1.0pt" width="252" |
'''Functional independence measure (FIM) (18 to 126) [Higher better]'''

| style="width:41.0pt; border:solid windowtext 1.0pt" width="55" | 98.6
| style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | 4.3
| style="width:33.9pt; border:solid windowtext 1.0pt" width="45" | 75.9
| style="width:36.55pt; border:solid windowtext 1.0pt" width="49" | 36
| style="width: 85px; border: 1pt solid windowtext;" width="63" | 22.7
| style="border: 1pt solid windowtext; width: 107px;" | 398.7 to 443.4
|}

'''Comments:''' 1. Study interpretation complicated by a third group of 20 patients randomised to psychotherapy. These patients gained similar improvements to those receiving HBOT, but some measures were not improved (statistically) compared to control. 2. Authors concluded HBOT was effective, and perhaps more effective than psychotherapy at improving mood in these patients. They hypothesise HBOT can improve mood through improving function. There is no indication how important the differences reported here were to the patients. 3. Note this study employed allocation using a random number table and included patient blinding.

'''Appraised by:'''Mike Bennett m.bennett@unsw.edu.au; Wednesday, 4 January 2023 '''Kill or Update By:''' Jan 2026

Feng - Revision history

M.bennett at 06:30, 4 January 2023

M.bennett: Created page with " '''The addition of hyper..."