http://hboevidence.wikis.unsw.edu.au/index.php?action=history&feed=atom&title=Hulshof
Hulshof - Revision history
2026-10-05T20:17:37Z
Revision history for this page on the wiki
MediaWiki 1.31.0
http://hboevidence.wikis.unsw.edu.au/index.php?title=Hulshof&diff=397&oldid=prev
M.bennett at 05:00, 9 July 2019
2019-07-09T05:00:05Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 05:00, 9 July 2019</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
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<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="color: <del class="diffchange diffchange-inline">#003366</del>; font-family: arial,helvetica,sans-serif<del class="diffchange diffchange-inline">; font-size: 130%</del>;">No evidence that hyperbaric oxygen influences cognitive disorders after irradiation of the brain</span><del class="diffchange diffchange-inline">'''</del></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">{| </del></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><span style="font-size:large;"></ins>'''<span style="color: <ins class="diffchange diffchange-inline">rgb(0, 51, 102)</ins>; font-family: arial, helvetica, sans-serif;">No evidence that hyperbaric oxygen influences cognitive disorders after irradiation of the brain</span>'''</span></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">| <span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Clinical Bottom Line:</del>''' </span><del class="diffchange diffchange-inline"><br><span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1. Very small sample sizes with low power </span><br><span </del>style="<del class="diffchange diffchange-inline">font-family: Arial,Helvetica,sans-serif; font-size</del>: <del class="diffchange diffchange-inline">120%</del>;"<del class="diffchange diffchange-inline">>2. No clear clinical implications </span> </del></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">{| </ins>style="<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">398px</ins>;"</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| style="width: 388px;" | <span style="font-size:larger;">'''Clinical Bottom Line:''' </span><br/> <span style="font-size:medium;">1. Very small sample sizes with low power<br/> <span style="font-family: Arial, Helvetica, sans-serif;">2. No clear clinical implications</span></span></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|}</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|}</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Citation:'''</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Citation:'''</span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Hulshof M, Stark N, Van der Kleij A, Sminia P, Smeding M, Gonzalez D. Hyperbaric oxygen therapy for cognitive disorders after irradiation of the brain. Strahlentherapie und Onkol 2001;177:192-8</span></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Hulshof M, Stark N, Van der Kleij A, Sminia P, Smeding M, Gonzalez D. Hyperbaric oxygen therapy for cognitive disorders after irradiation of the brain. Strahlentherapie und Onkol 2001;177:192-8</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Lead author's name and fax:''' [[mailto:m.c.hulshof@amc.uva.nl | m.c.hulshof@amc.uva.nl]]</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Lead author's name and fax:''' [[mailto:m.c.hulshof@amc.uva.nl| m.c.hulshof@amc.uva.nl]]</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Three-part Clinical Question:''' For patients with cognitive deficit following brain irradiation, dose the application of HBOT result in any improvement in function?</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Three-part Clinical Question:''' For patients with cognitive deficit following brain irradiation, dose the application of HBOT result in any improvement in function?</span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Search Terms:''' Cognitive disorders, Brain irradiation, Late radiation effects</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Search Terms:''' Cognitive disorders, Brain irradiation, Late radiation effects</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study:''' Single-blinded randomised controlled trial without intention-to-treat.</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study:''' Single-blinded randomised controlled trial without intention-to-treat.</span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study Patients:''' Adult patients with cognitive impairment at least 1.5 years after radiation</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study Patients:''' Adult patients with cognitive impairment at least 1.5 years after radiation</span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Control group''' (n= 3) Nil specific treatment</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Control group''' (n= 3) Nil specific treatment</span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Experimental group''' (n=4) 30 hyperbaric treatments at 3ATA for 115 minutes</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Experimental group''' (n=4) 30 hyperbaric treatments at 3ATA for 115 minutes</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Evidence:'''</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Evidence:'''</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>{|  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>{| style<ins class="diffchange diffchange-inline">=</ins>"<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">713px</ins>;"</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">| <span </del>style<del class="diffchange diffchange-inline">'''</del>"<del class="diffchange diffchange-inline">display</del>: <del class="diffchange diffchange-inline">block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Non-Event Outcomes''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Time to outcome/s''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Control group''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''HBOT group''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center</del>;"<del class="diffchange diffchange-inline">>'''P-value''' </span></span> </del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>| <del class="diffchange diffchange-inline"><span </del>style<del class="diffchange diffchange-inline">'''</del>"<del class="diffchange diffchange-inline">font-family: Arial,Helvetica,sans-serif; font-size</del>: <del class="diffchange diffchange-inline">110%</del>;"<del class="diffchange diffchange-inline">>31 neuropsychological tests</del><<del class="diffchange diffchange-inline">/</del>span><<del class="diffchange diffchange-inline">br</del>><del class="diffchange diffchange-inline"><span style</del>'''<del class="diffchange diffchange-inline">"font</del>-<del class="diffchange diffchange-inline">family: Arial,Helvetica,sans-serif; font-size: 110%;"</del>><del class="diffchange diffchange-inline">Mean difference only indicated for one</del></span> |<del class="diffchange diffchange-inline">| <span </del>style<del class="diffchange diffchange-inline">'''</del>"<del class="diffchange diffchange-inline">display</del>: <del class="diffchange diffchange-inline">block</del>; text-align: center;"><span <del class="diffchange diffchange-inline">style</del>'''<del class="diffchange diffchange-inline">"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">directly after HBO</del></span></span> |<del class="diffchange diffchange-inline">| <span </del>style<del class="diffchange diffchange-inline">'''</del>"<del class="diffchange diffchange-inline">display</del>: <del class="diffchange diffchange-inline">block</del>; text-align: center;"><span <del class="diffchange diffchange-inline">style</del>'''<del class="diffchange diffchange-inline">"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">not given</del></span></span> |<del class="diffchange diffchange-inline">| <span </del>style<del class="diffchange diffchange-inline">'''</del>"<del class="diffchange diffchange-inline">display</del>: <del class="diffchange diffchange-inline">block</del>; text-align: center;"><span <del class="diffchange diffchange-inline">style</del>'''<del class="diffchange diffchange-inline">"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">not given</del></span></span> |<del class="diffchange diffchange-inline">| <span </del>style<del class="diffchange diffchange-inline">'''</del>"<del class="diffchange diffchange-inline">display</del>: <del class="diffchange diffchange-inline">block</del>; text-align: center;"><span <del class="diffchange diffchange-inline">style</del>'''<del class="diffchange diffchange-inline">"display: block; font</del>-<del class="diffchange diffchange-inline">family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">0.016</del></span></span>  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| style<ins class="diffchange diffchange-inline">=</ins>"<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">239px</ins>;" <ins class="diffchange diffchange-inline">| </ins><span><<ins class="diffchange diffchange-inline">span</ins>>'''<ins class="diffchange diffchange-inline">Non</ins>-<ins class="diffchange diffchange-inline">Event Outcomes'''</span</ins>></span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| style<ins class="diffchange diffchange-inline">=</ins>"<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">119px</ins>; text-align: center;" <ins class="diffchange diffchange-inline">| <span</ins>><span<ins class="diffchange diffchange-inline">>'''Time to outcome/s</ins>'''</span></span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| style<ins class="diffchange diffchange-inline">=</ins>"<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">101px</ins>; text-align: center;" <ins class="diffchange diffchange-inline">| <span</ins>><span<ins class="diffchange diffchange-inline">>'''Control group</ins>'''</span></span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| style<ins class="diffchange diffchange-inline">=</ins>"<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">113px</ins>; text-align: center;" <ins class="diffchange diffchange-inline">| <span</ins>><span<ins class="diffchange diffchange-inline">>'''HBOT group</ins>'''</span></span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>| style<ins class="diffchange diffchange-inline">=</ins>"<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">107px</ins>; text-align: center;" <ins class="diffchange diffchange-inline">| <span</ins>><span<ins class="diffchange diffchange-inline">></ins>'''<ins class="diffchange diffchange-inline">P</ins>-<ins class="diffchange diffchange-inline">value'''</ins></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| style="width: 239px;" | <span>31 neuropsychological tests</span><br/> <span>Mean difference only indicated for one</span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| style="width: 119px; text-align: center;" | <span><span>directly after HBO</span></span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| style="width: 101px; text-align: center;" | <span><span>not given</span></span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| style="width: 113px; text-align: center;" | <span><span>not given</span></span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| style="width: 107px; text-align: center;" | <span><span>0.016</span></span></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|}</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|}</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Comments:'''</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Comments:'''</span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1.The one test outcome that significantly improved was a self-assesment test, and could have been influenced by not being blinded</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1.The one test outcome that significantly improved was a self-assesment test, and could have been influenced by not being blinded</span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">2. Multiple comparisons in small sample size means high probability that this finding could be due to chance</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">2. Multiple comparisons in small sample size means high probability that this finding could be due to chance</span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">3. Differences between control group and experimental group in tumour type, localization and radiation field</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">3. Differences between control group and experimental group in tumour type, localization and radiation field</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Appraised by''': Annelies van der Hulst, Hyperbaric Unit, Prince of Wales Hospital, Randwick NSW.; Tuesday 16th August 2005 Email: [[mailto:m.bennett@unsw.edu.au | m.bennett@unsw.edu.au]]</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Appraised by''': Annelies van der Hulst, Hyperbaric Unit, Prince of Wales Hospital, Randwick NSW.; Tuesday 16th August 2005 Email: [[mailto:m.bennett@unsw.edu.au| m.bennett@unsw.edu.au]]</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Kill or Update By:''' December 2020</span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Kill or Update By:''' December 2020</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[File:<del class="diffchange diffchange-inline">sumhorsa</del>.gif|center]]</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[File:<ins class="diffchange diffchange-inline">Sumhorsa</ins>.gif|center<ins class="diffchange diffchange-inline">|Sumhorsa.gif</ins>]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="color: #7c00ff; display: block; font-family: arial,helvetica,sans-serif; font-size: 26px; text-align: center;">'''[[<del class="diffchange diffchange-inline">Radiation tissue injury  </del>| <del class="diffchange diffchange-inline"> </del>BACK]]'''</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="color: #7c00ff; display: block; font-family: arial,helvetica,sans-serif; font-size: 26px; text-align: center;">'''[[<ins class="diffchange diffchange-inline">Radiation_tissue_injury</ins>|BACK]]'''</span></div></td></tr>
</table>
M.bennett
http://hboevidence.wikis.unsw.edu.au/index.php?title=Hulshof&diff=123&oldid=prev
Gordoben: Imported from Wikispaces
2017-12-11T02:48:48Z
<p>Imported from Wikispaces</p>
<p><b>New page</b></p><div>'''<span style="color: #003366; font-family: arial,helvetica,sans-serif; font-size: 130%;">No evidence that hyperbaric oxygen influences cognitive disorders after irradiation of the brain</span>'''<br />
{| <br />
| <span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Clinical Bottom Line:''' </span><br><span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1. Very small sample sizes with low power </span><br><span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">2. No clear clinical implications </span> <br />
|-<br />
|}<br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Citation:'''</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">Hulshof M, Stark N, Van der Kleij A, Sminia P, Smeding M, Gonzalez D. Hyperbaric oxygen therapy for cognitive disorders after irradiation of the brain. Strahlentherapie und Onkol 2001;177:192-8</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Lead author's name and fax:''' [[mailto:m.c.hulshof@amc.uva.nl | m.c.hulshof@amc.uva.nl]]</span><br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Three-part Clinical Question:''' For patients with cognitive deficit following brain irradiation, dose the application of HBOT result in any improvement in function?</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Search Terms:''' Cognitive disorders, Brain irradiation, Late radiation effects</span><br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study:''' Single-blinded randomised controlled trial without intention-to-treat.</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study Patients:''' Adult patients with cognitive impairment at least 1.5 years after radiation</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Control group''' (n= 3) Nil specific treatment</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Experimental group''' (n=4) 30 hyperbaric treatments at 3ATA for 115 minutes</span><br />
<br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Evidence:'''</span><br />
<br />
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| <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Non-Event Outcomes''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Time to outcome/s''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Control group''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''HBOT group''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''P-value''' </span></span> <br />
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| <span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">31 neuropsychological tests</span><br><span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Mean difference only indicated for one</span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">directly after HBO</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">not given</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">not given</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">0.016</span></span> <br />
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Comments:'''</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1.The one test outcome that significantly improved was a self-assesment test, and could have been influenced by not being blinded</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">2. Multiple comparisons in small sample size means high probability that this finding could be due to chance</span><br />
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">3. Differences between control group and experimental group in tumour type, localization and radiation field</span><br />
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Appraised by''': Annelies van der Hulst, Hyperbaric Unit, Prince of Wales Hospital, Randwick NSW.; Tuesday 16th August 2005 Email: [[mailto:m.bennett@unsw.edu.au | m.bennett@unsw.edu.au]]</span><br />
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Kill or Update By:''' December 2020</span><br />
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<span style="color: #7c00ff; display: block; font-family: arial,helvetica,sans-serif; font-size: 26px; text-align: center;">'''[[Radiation tissue injury | BACK]]'''</span></div>
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