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2018-01-20T23:25:49Z

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'''Hyperbaric oxygenation improved transcutaneous oximetry and other vascular parameters in diabetic feet''' 

'''Clinical Bottom Line:''' 
1. No clinical results given 
2. Transcutanoeus oxygen readings improved over a course of HBOT 

'''Appraised by:''' Mike Bennett, Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney; Monday, 13 August 2001 

'''Clinical Scenario:''' An insulin dependent diabetic with a lesion on the foot presented for hyperbaric therapy. 

'''Three-part Question:''' For patients with diabetic foot ulcers, does the additional administration of hyperbaric oxygen, compared to a standard care regime alone, result in any improvement in clinical healing or interim indicators of improved vascular state? 
'''Search Terms:''' Diabetes mellitus, chronic ulcers 

'''The Study:''' 
?Blinded randomised controlled trial, intention-to-treat unknown. 
Known diabetics with Wagner Grade 0 to 2 lesions of the feet. 
'''Control group''' (N = 12; 12 analysed): Treated for diabetic feet, details unknown. 
'''Experimental group''' (N = 17; 17 analysed): Same treatment as controls but with addition of HBO, dose unknown. 

'''The Evidence:''' 

'''Non-Event Outcomes Time to outcome Control group Hyperbaric group P-value''' 

Transcutaneous oximetry 30 treatments 36 +-21 58 +-21 <0.01 
(mmHg) 

HbA1C (%) 30 treatments 9.3 +-4.3 6.6 +-1.7 <0.01 

Laser-doppler perfusion (flux) 30 treatments 26 +-4 36 +-7 <0.01 

Ankle Brachial Index 30 treatments NS 

'''Comments:''' 
1. No clinical outcome information 
2. Abstract only, few details 

'''Expiry date:''' July 2021

'''References:''' 
1. Lin TF, Chen SB, Niu KC. The vascular effects of hyperbaric oxygen therapy in treatment of early diabetic foot. Undersea and Hyperbaric Medicine 2001; 28 (Suppl):67. 



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Gordoben: Imported from Wikispaces