M.bennett at 02:14, 19 October 2021

2021-10-19T02:14:56Z

M.bennett: Created page with " '''A meta-analysis of randomised trials did not establish any benefit in neuropsychological outcome with hyperba..."

2021-10-19T02:09:47Z

Created page with " '''A meta-analysis of randomised trials did not establish any benefit in neuropsychological outcome with hyperba..."

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'''A meta-analysis of randomised trials did not establish any benefit in neuropsychological outcome with hyperbaric oxygen treatment for carbon monoxide poisoning compared to normobaric oxygen.'''

'''Citation:'''1.Lin CH, Su WH, Chen YC, Feng PH, Shen WC, Ong JR, Wu MY, Wong CS. Treatment with normobaric or hyperbaric oxygen and its effect on neuropsychometric dysfunction after carbon monoxide poisoning: A systematic review and meta-analysis of randomized controlled trials. Medicine. 2018 Sep;97(39).

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'''Background:'''

Carbon monoxide (CO) poisoning may result in acute neurological sequelae, cognitive sequelae, and delay neurological sequelae. The administration of hyperbaric oxygen (HBO) to prevent the development of delayed neurological sequelae in CO poisoning have extensively investigated but conflicting results have been reported. We performed a systematic literature review and meta-analysis of randomized controlled trials (RCTs) evaluating HBO treatment and its effect on neuropsychometric dysfunction after CO poisoning.

'''Methods:'''

We searched Medline, Embase, Pubmed, and the Cochrane Register of Controlled Trials from inception to December 2017. Eligible studies compared HBO therapy with normobaric oxygen (NBO) in patients with CO poisoning.

'''Results:'''

Six studies compared HBO with NBO in CO poisoning patients. The outcomes were persisting neuropsychological symptoms between 2 hours and six months after treatment.

Compared with patients treated with NBO, patients treated with HBO reported:

Headache (16.2% vs 16.5%, relative risk, [RR] = 0.83, 95%CI = 0.38–1.80)

Memory impairment (18.2% vs 23.8%, RR = 0.80, 95 CI = 0.43–1.49)

Difficulty concentrating (15.0% vs 18.4%, RR = 0.86, 95%CI = 0.55–1.34

Disturbed sleep (14.7% vs 16.2%, RR=0.91, 95% CI=0.59–1.39).

Two sessions of HBO treatment exhibited no advantage over one session.

'''Conclusions:'''

The meta-analysis indicated that compared with CO poisoning patients treated with NBO, HBO treated patients have a lower incidence of neuropsychological sequelae, including headache, memory impairment, difficulty concentrating, disturbed sleep, and delayed neurological sequelae.

Taking into consideration the cost-effectiveness of one session of HBO, one session of HBO treatment could be an economical option for patients with CO poisoning with high severity.

'''Keywords:'''carbon monoxide poisoning, hyperbaric oxygen, neuropsychometric dysfunction

 

'''HBOEvidence comments:'''

#None of the differences estimated was of statistical significance and there we cannot be sure these effects are real. The authors’ conclusion seems unjustified.
#Outcomes were not standardised between studies and were measured between 2 hours and one year after treatment.

'''Appraised by: '''Mike Bennett m.bennett@unsw.edu.au

'''Update by:''' October 2025

@@ Line 20: / Line 20: @@
 <span style="font-size:12.0pt"><span style="line-height:107%">Compared with patients treated with NBO, patients treated with HBO reported:</span></span>
-<span style="font-size:12.0pt"><span style="line-height:107%">Headache (16.2% vs 16.5%, relative risk, [RR] = 0.83, 95%CI = 0.38–1.80)</span></span>
+<span style="font-size:12.0pt"><span style="line-height:107%">Headache (16.2% vs 16.5%, relative risk, [RR] = 0.83, 95%CI = 0.38–1.80).</span></span>
-<span style="font-size:12.0pt"><span style="line-height:107%">Memory impairment (18.2% vs 23.8%, RR = 0.80, 95 CI = 0.43–1.49)</span></span>
+<span style="font-size:12.0pt"><span style="line-height:107%">Memory impairment (18.2% vs 23.8%, RR = 0.80, 95 CI = 0.43–1.49).</span></span>
-<span style="font-size:12.0pt"><span style="line-height:107%">Difficulty concentrating (15.0% vs 18.4%, RR = 0.86, 95%CI = 0.55–1.34</span></span>
+<span style="font-size:12.0pt"><span style="line-height:107%">Difficulty concentrating (15.0% vs 18.4%, RR = 0.86, 95%CI = 0.55–1.34).</span></span>
 <span style="font-size:12.0pt"><span style="line-height:107%">Disturbed sleep (14.7% vs 16.2%, RR=0.91, 95% CI=0.59–1.39).</span></span>
@@ Line 48: / Line 48: @@
 <span style="font-size: 16px;">'''Update by:''' October 2025</span>

Lin3 - Revision history

M.bennett at 02:14, 19 October 2021

M.bennett: Created page with " '''A meta-analysis of randomised trials did not establish any benefit in neuropsychological outcome with hyperba..."