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2012-01-28T02:34:15Z

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'''Some evidence that mild to moderately affected patients with multiple sclerosis may benefit from hyperbaric oxygen therapy.''' 

'''Clinical Bottom Line:''' 
1. Unclear due to brevity of the abstract. 
2. Poor evidence of improvement in those with Kurtzke extended disability grades 6 or less whom were given hyperbaric oxygen. 

'''Appraised by:''' Mike Bennett, Dept. of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney; Saturday, 13 March 1999 

'''Clinical Scenario:''' A patient with multiple sclerosis presented for consideration of treatment with hyperbaric oxygen 
'''Three-part Question''': In patients with multiple sclerosis, does the administration of hyperbaric oxygen, in addition to other measures, result in any prevention of deterioration or improvement in function or symptoms? 
'''Search Terms:''' Hyperbaric oxygenation, multiple sclerosis 

'''The Study:''' 
Double-blinded randomised controlled trial intention-to-treat unknown. 
Patients with multiple sclerosis, no other details. Total of 40 patients. 
Control group: Compressed air, probably at 2ATA, for 90 minutes daily, 5 days each week for one month. 
Experimental group: 100% oxygen at 2ATA for 90 minutes on the same schedule as above 

'''The Evidence:''' 
Not clearly stated. Patients with low Kurtzke Extended Disability grades (<7): 7 out of 9 patients in HBO group improved, 0/? In the placebo group improved. 

'''Comments:''' 
1. Brief abstract only with no clear data. 40 randomised patients. 
2. Authors suggest a differential treatment effect on patients with low Kurtzke grades (6 or less). 
3. No reported overall significant differences at 3 weeks in neurology assessment, Kurtzke Extended Disability, evoked potentials or spinal fluid examination. 

'''Expiry date:''' January 2015 
'''References:''' 
1. Murthy KN, Maurice PB, Wilmeth JB. Double-blind randomised study of hyperbaric oxygen (HBO) versus placebo in multiple sclerosis (MS). Neurology 1985; 35(Suppl 1):104. 

[[File:http://www.hboevidence.com/_themes/copy-of-sumi-painting/sumhorsa.gif|center|external]]

'''[[Multiple Sclerosis | BACK]]'''

Murthy - Revision history

Gordoben: Imported from Wikispaces