M.bennett at 01:38, 10 October 2021

2021-10-10T01:38:34Z

Gordoben: Imported from Wikispaces

2019-01-18T06:26:51Z

Imported from Wikispaces

New page

'''Hyperbaric oxygen may be associated with some reduction in wound size, exudate and hyperaemia following a standard injury model.'''

'''Clinical Bottom Line:'''
# The addition of hyperbaric oxygen treatment in this model of a burn injury was associated with a reduction of wound size, exudate and hyperaemia on day 2 only. 

**Appraised by:''' Mike Bennett, Dept of Diving and Hyperbaric Medicine, Prince of Wales Hospital
Sydney; Thursday, 25 March 1999

**Clinical Scenario:''' A patient with thermal burns presented for treatment, we wondered if adding hyperbaric oxygen to the treatment would improve outcome. 
**Three-part Question:''' For patients with thermal burns, does the addition of hyperbaric oxygen to the standard treatment result in any improvement in the rate of healing?
**Search Terms:''' burns

**The Study:'''
Double-blinded concealed randomised controlled trial with intention-to-treat.
Healthy, non-smoking volunteers with a standard wound inflicted on the forearm.
'''Control group''' (N =6;6 analysed): Blister formed by suction, de-roofed and irradiated with UV light in a standard way. Wound then covered with hydrocolloid dressing renewed daily. Sham hyperbaric treatment started within 2 hours, twice daily for three days, at 2.4ATA on 8.75% oxygen for three thirty minute periods separated by 10 minute air breaks. 100% oxygen decompression.
'''Experimental group''' (N =6;6 analysed): As above, but hyperbaric sessions involved breathing of 100% oxygen for three thirty minute periods separated by 10 minute air breaks.

**The Evidence:'''
{|
| '''Non-event outcomes''' || '''Time to outcome''' || '''Control group''' || '''HBO group''' || '''P-value'''
|-
| '''Hyperaemia(perfusion units)''' || Day 2 || 25.0 || 14.4 || 0.05
|-
| '''exudate/day (g)''' || Day 2 || 0.30 || 0.19 || 0.03
|-
| '''Wound size (cm2)''' || Day 2 || 0.95 || 0.61 || 0.04
|-
|}

'''Comments:'''
1. Statistically significant differences on day two only.
2. Possibly inappropriate use of statistical analysis by use of multiple one-tail t-tests at times that may not have been a priori.
3. Clinical relevance unclear.

**Expiry date:''' December 2024
**References: '''
1. Niezgoda JA, Cianci P, Folden BW, Ortega RL, Slade JB, Storrow AB. The effect of hyperbaric oxygen therapy on a burn wound model in human volunteers. Plastic and Reconstructive Surgery 1997; 99:1620-1625.



[[File:sumhorsa.gif|center]]

'''[[Burns | BACK]]'''

Niezgoda - Revision history

M.bennett at 01:38, 10 October 2021

Gordoben: Imported from Wikispaces