http://hboevidence.wikis.unsw.edu.au/index.php?action=history&feed=atom&title=Oley
Oley - Revision history
2026-10-03T23:33:19Z
Revision history for this page on the wiki
MediaWiki 1.31.0
http://hboevidence.wikis.unsw.edu.au/index.php?title=Oley&diff=1371&oldid=prev
M.bennett at 02:57, 24 August 2022
2022-08-24T02:57:56Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 02:57, 24 August 2022</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l4" >Line 4:</td>
<td colspan="2" class="diff-lineno">Line 4:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-size:14.0pt"><span style="font-family:">Clinical bottom line:</span></span>'''</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-size:14.0pt"><span style="font-family:">Clinical bottom line:</span></span>'''</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:14.0pt"><span style="font-family:">No outcomes was assessed between groups after institution of HBO compared to control</span></span>  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:14.0pt"><span style="font-family:">No outcomes was assessed between groups after institution of HBO compared to control<ins class="diffchange diffchange-inline">.</span></span> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">&nbsp;<span style="font-size:larger;">'''<span style="font-family:">Citation/s:</span>'''<span style="font-family:">1. Oley MH, Oley MC, Noersasongko AD, Hatta M, Philips GG, Faruk M, Kalangi JA, Rumampuk IM, Tulong MT. Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: a randomised controlled trial study. International Journal of Surgery Open. 29(2021) 33-39.</ins></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>----</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>----</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><span style="font-size:larger;">'''<span style="font-family:">Citation/s:</span>'''<span style="font-family:">1. Oley MH, Oley MC, Noersasongko AD, Hatta M, Philips GG, Faruk M, Kalangi JA, Rumampuk IM, Tulong MT. Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: a randomised controlled trial study. International Journal of Surgery Open. 29(2021) 33-39.</span></span></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Lead author’s name and fax:</span>'''<span style="font-family:">M. H. Oley&nbsp;: mendy.hatibie@unsrat.ac.id</span></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Lead author’s name and fax:</span>'''<span style="font-family:">M. H. Oley&nbsp;: mendy.hatibie@unsrat.ac.id</span></span></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">&nbsp;</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Three-part Clinical Question:</span>'''<span style="font-family:">In patients with crush injury, does the addition of hyperbaric oxygen to standard therapy, compared to standard therapy alone, result in increased VEGF serum and mRNA levels?</span></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Three-part Clinical Question:</span>'''<span style="font-family:">In patients with crush injury, does the addition of hyperbaric oxygen to standard therapy, compared to standard therapy alone, result in increased VEGF serum and mRNA levels?</span></span></div></td></tr>
</table>
M.bennett
http://hboevidence.wikis.unsw.edu.au/index.php?title=Oley&diff=1237&oldid=prev
M.bennett at 02:39, 4 January 2022
2022-01-04T02:39:02Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 02:39, 4 January 2022</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-size:18.0pt"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">No comparisons made after treatment of crush injuries between hyperbaric oxygen group and control.</span></span>'''</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-size:18.0pt"><span style="font-family:">No comparisons made after treatment of crush injuries between hyperbaric oxygen group and control.</span></span>'''</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-size:14.0pt"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Clinical bottom line:</span></span>'''</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-size:14.0pt"><span style="font-family:">Clinical bottom line:</span></span>'''</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:14.0pt"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">No outcomes was assessed between groups after institution of HBO compared to control</span></span>  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:14.0pt"><span style="font-family:">No outcomes was assessed between groups after institution of HBO compared to control</span></span>  </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>----</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>----</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Citation/s:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">1. Oley MH, Oley MC, Noersasongko AD, Hatta M, Philips GG, Faruk M, Kalangi JA, Rumampuk IM, Tulong MT. Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: a randomised controlled trial study. International Journal of Surgery Open. 29(2021) 33-39.</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Citation/s:</span>'''<span style="font-family:">1. Oley MH, Oley MC, Noersasongko AD, Hatta M, Philips GG, Faruk M, Kalangi JA, Rumampuk IM, Tulong MT. Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: a randomised controlled trial study. International Journal of Surgery Open. 29(2021) 33-39.</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Lead author’s name and fax:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">M. H. Oley : mendy.hatibie@unsrat.ac.id</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Lead author’s name and fax:</span>'''<span style="font-family:">M. H. Oley<ins class="diffchange diffchange-inline">&nbsp;</ins>: mendy.hatibie@unsrat.ac.id</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Three-part Clinical Question:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">In patients with crush injury, does the addition of hyperbaric oxygen to standard therapy, compared to standard therapy alone, result in increased VEGF serum and mRNA levels?</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Three-part Clinical Question:</span>'''<span style="font-family:">In patients with crush injury, does the addition of hyperbaric oxygen to standard therapy, compared to standard therapy alone, result in increased VEGF serum and mRNA levels?</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Search Terms:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Crush injury; vascular endothelial growth factor; wound healing</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Search Terms:</span>'''<span style="font-family:">Crush injury; vascular endothelial growth factor; wound healing</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">The Study:</span>'''<span style="font-size: larger; font-family: <del class="diffchange diffchange-inline">" times="" new="" roman",="" serif;"="</del>">Non-blinded non-concealed randomised controlled trial with intention-to-treat.</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''<span style="font-family:">The Study:</span>'''<span style="font-size: larger; font-family:">Non-blinded non-concealed randomised controlled trial with intention-to-treat.</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">The Study Patients:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Patients between 15-64 years old admitted with crush injury. Patients with contraindications to receiving HBO were excluded.</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">The Study Patients:</span>'''<span style="font-family:">Patients between 15-64 years old admitted with crush injury. Patients with contraindications to receiving HBO were excluded.</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Control group</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">(N = 8; 8 analysed): Wound debridement and limb salvage surgery.</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Control group</span>'''<span style="font-family:">(N = 8; 8 analysed): Wound debridement and limb salvage surgery.</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Experimental group</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">(N = 7; 7 analysed): Wound debridement and limb salvage surgery followed by HBOT 100% O2 at 2.4 ATA for 60 minutes daily for 10 consecutive days.</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Experimental group</span>'''<span style="font-family:">(N = 7; 7 analysed): Wound debridement and limb salvage surgery followed by HBOT 100% O2 at 2.4 ATA for 60 minutes daily for 10 consecutive days.</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">The Evidence:</span>'''</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">The Evidence:</span>'''</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style=<del class="diffchange diffchange-inline">"font-family: " times="" new="" roman",="" serif;="</del>" font-size:<del class="diffchange diffchange-inline">="" </del>larger;<del class="diffchange diffchange-inline">"="</del>">No comparisons made between groups after HBO course.</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">No comparisons made between groups after HBO course.</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Comments:</span>'''</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Comments:</span>'''</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">No outcomes assessed with which to compare HBO plus standard care to standard care alone.</span></span>  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:">No outcomes assessed with which to compare HBO plus standard care to standard care alone.</span></span>  </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">The sample size was very small with no sample size calculation described.</span></span>  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:">The sample size was very small with no sample size calculation described.</span></span>  </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Follow up period was limited to 0 days in the control group and 10 days in the hyperbaric group. No long-term conclusions can be drawn.</span></span>  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:">Follow up period was limited to 0 days in the control group and 10 days in the hyperbaric group. No long-term conclusions can be drawn.</span></span>  </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>"><span style="color:black">The authors’ analysis looked at serum VEGF and VEGF mRNA. It is not clear why they did not compare groups at the 10 day point.</span></span></span>  </div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>#<span style="font-size:larger;"><span style="font-family:"><span style="color:black">The authors’ analysis looked at serum VEGF and VEGF mRNA. It is not clear why they did not compare groups at the 10 day point.</span></span></span>  </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&nbsp;</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Appraised by:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Hannah Rubinstein h.rubinstein@student.unsw.edu.au; Monday, 6 December 2021</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:larger;">'''<span style="font-family:">Appraised by:<ins class="diffchange diffchange-inline">&nbsp;</ins></span>'''<span style="font-family:">Hannah Rubinstein h.rubinstein@student.unsw.edu.au; Monday, 6 December 2021</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">'''</del><span style="font-<del class="diffchange diffchange-inline">family</del>:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Kill or Update By:</span><del class="diffchange diffchange-inline">'''</del><<del class="diffchange diffchange-inline">span </del>style="<del class="diffchange diffchange-inline">font</del>-<del class="diffchange diffchange-inline">size</del>: <del class="diffchange diffchange-inline">larger</del>; <del class="diffchange diffchange-inline">font</del>-<del class="diffchange diffchange-inline">family</del>: " <del class="diffchange diffchange-inline">times</del>=<del class="diffchange diffchange-inline">"" new</del>=<del class="diffchange diffchange-inline">"" roman",</del>="<del class="diffchange diffchange-inline">" serif</del>;<del class="diffchange diffchange-inline">"="</del>"><del class="diffchange diffchange-inline">November 2025</del></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-<ins class="diffchange diffchange-inline">size</ins>:<ins class="diffchange diffchange-inline">larger;</ins>"><ins class="diffchange diffchange-inline">'''</ins>Kill or Update By:<ins class="diffchange diffchange-inline">&nbsp;'''November 2025</ins></span></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><<ins class="diffchange diffchange-inline">p </ins>style="<ins class="diffchange diffchange-inline">text</ins>-<ins class="diffchange diffchange-inline">align</ins>: <ins class="diffchange diffchange-inline">center;">&nbsp</ins>;<ins class="diffchange diffchange-inline"></p> <p style="text</ins>-<ins class="diffchange diffchange-inline">align</ins>: <ins class="diffchange diffchange-inline">center;</ins>"<ins class="diffchange diffchange-inline">>[[File:Sumhorsa.gif|center|sumhorsa.gif]]</p> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== <ins class="diffchange diffchange-inline"><span style</ins>="<ins class="diffchange diffchange-inline">font-size:xx-large</ins>;"><ins class="diffchange diffchange-inline">[[Crush_injuries|BACK]]</ins></span> <ins class="diffchange diffchange-inline">==</ins></div></td></tr>
</table>
M.bennett
http://hboevidence.wikis.unsw.edu.au/index.php?title=Oley&diff=1234&oldid=prev
M.bennett: Created page with " '''<span style="font-size:18.0pt"><span style="font-family:" times="" new="" roman",serif"="">No comparisons made after treatment of crush injuries between hyperbaric oxygen..."
2022-01-04T02:28:35Z
<p>Created page with " '''<span style="font-size:18.0pt"><span style="font-family:" times="" new="" roman",serif"="">No comparisons made after treatment of crush injuries between hyperbaric oxygen..."</p>
<p><b>New page</b></p><div><br />
'''<span style="font-size:18.0pt"><span style="font-family:" times="" new="" roman",serif"="">No comparisons made after treatment of crush injuries between hyperbaric oxygen group and control.</span></span>'''<br />
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'''<span style="font-size:14.0pt"><span style="font-family:" times="" new="" roman",serif"="">Clinical bottom line:</span></span>'''<br />
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#<span style="font-size:14.0pt"><span style="font-family:" times="" new="" roman",serif"="">No outcomes was assessed between groups after institution of HBO compared to control</span></span> <br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Citation/s:</span>'''<span style="font-family:" times="" new="" roman",serif"="">1. Oley MH, Oley MC, Noersasongko AD, Hatta M, Philips GG, Faruk M, Kalangi JA, Rumampuk IM, Tulong MT. Effects of hyperbaric oxygen therapy on vascular endothelial growth factor protein and mRNA in crush injury patients: a randomised controlled trial study. International Journal of Surgery Open. 29(2021) 33-39.</span></span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Lead author’s name and fax:</span>'''<span style="font-family:" times="" new="" roman",serif"="">M. H. Oley : mendy.hatibie@unsrat.ac.id</span></span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Three-part Clinical Question:</span>'''<span style="font-family:" times="" new="" roman",serif"="">In patients with crush injury, does the addition of hyperbaric oxygen to standard therapy, compared to standard therapy alone, result in increased VEGF serum and mRNA levels?</span></span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Search Terms:</span>'''<span style="font-family:" times="" new="" roman",serif"="">Crush injury; vascular endothelial growth factor; wound healing</span></span><br />
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'''<span style="font-family:" times="" new="" roman",serif"="">The Study:</span>'''<span style="font-size: larger; font-family: " times="" new="" roman",="" serif;"="">Non-blinded non-concealed randomised controlled trial with intention-to-treat.</span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">The Study Patients:</span>'''<span style="font-family:" times="" new="" roman",serif"="">Patients between 15-64 years old admitted with crush injury. Patients with contraindications to receiving HBO were excluded.</span></span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Control group</span>'''<span style="font-family:" times="" new="" roman",serif"="">(N = 8; 8 analysed): Wound debridement and limb salvage surgery.</span></span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Experimental group</span>'''<span style="font-family:" times="" new="" roman",serif"="">(N = 7; 7 analysed): Wound debridement and limb salvage surgery followed by HBOT 100% O2 at 2.4 ATA for 60 minutes daily for 10 consecutive days.</span></span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">The Evidence:</span>'''</span><br />
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<span style="font-family: " times="" new="" roman",="" serif;="" font-size:="" larger;"="">No comparisons made between groups after HBO course.</span><br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Comments:</span>'''</span><br />
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#<span style="font-size:larger;"><span style="font-family:" times="" new="" roman",serif"="">No outcomes assessed with which to compare HBO plus standard care to standard care alone.</span></span> <br />
#<span style="font-size:larger;"><span style="font-family:" times="" new="" roman",serif"="">The sample size was very small with no sample size calculation described.</span></span> <br />
#<span style="font-size:larger;"><span style="font-family:" times="" new="" roman",serif"="">Follow up period was limited to 0 days in the control group and 10 days in the hyperbaric group. No long-term conclusions can be drawn.</span></span> <br />
#<span style="font-size:larger;"><span style="font-family:" times="" new="" roman",serif"=""><span style="color:black">The authors’ analysis looked at serum VEGF and VEGF mRNA. It is not clear why they did not compare groups at the 10 day point.</span></span></span> <br />
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<span style="font-size:larger;">'''<span style="font-family:" times="" new="" roman",serif"="">Appraised by:</span>'''<span style="font-family:" times="" new="" roman",serif"="">Hannah Rubinstein h.rubinstein@student.unsw.edu.au; Monday, 6 December 2021</span></span><br />
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'''<span style="font-family:" times="" new="" roman",serif"="">Kill or Update By:</span>'''<span style="font-size: larger; font-family: " times="" new="" roman",="" serif;"="">November 2025</span></div>
M.bennett