Porubsky - Revision history

M.bennett at 07:01, 3 January 2023

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M.bennett at 06:53, 3 January 2023

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M.bennett: Created page with " '''There was no differ..."

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Created page with " '''There was no differ..."

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'''There was no difference in the outcome from the treatment of tinnitus with two different hyperbaric oxygen regimens.'''

{| class="Table" style="width:375.0pt; border:undefined" width="0"
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'''Clinical Bottom Line:'''

'''1. No difference in outcome between the two HBOT groups'''

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'''Citation/s:'''1.Porubsky, C., Stiegler, P., Matzi, V., Lipp, C., Kontaxis, A., Klemen, H., Smolle-Jüttner, F. Hyperbaric oxygen in tinnitus: Influence of psychological factors on treatment results? ORL : Journal for Oto - Rhino - Laryngology and its Related Specialties,2007; 69(2):107-12.

'''Lead author's name and fax:'''Christian Porubsky: christian.porubsky@klinikum-graz.at

'''Three-part Clinical Question:'''For patients with tinnitus, does HBOT at 2.2 ATA for 60 mins daily for 15 days compared to a 2.5 ATA treatment on the same schedule result in any greater resolution of symptoms? '''Search Terms:''' tinnitus, hearing loss, retraining

'''The Study:'''Non-blinded randomised controlled trial with intention-to-treat. '''The Study Patients:''' Patients presenting for the treatment of tinnitus (time from onset from < 2 wks to > 1 year). '''Control group''' (N = 180; 180 analysed): 100% oxygen breathing at 2.2 ATA for 60 minutes daily for 15 working days. '''Experimental group''' (N = 180; 180 analysed): As above but at 2.5 ATA.

'''The Evidence:'''

{| class="Table" style="border:solid windowtext 1.0pt"
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| style="width:68.4pt; border:solid windowtext 1.0pt" width="94" | '''Outcome'''
| style="width:45.3pt; border:solid windowtext 1.0pt" width="64" | '''Time to Outcome'''
| style="width:43.85pt; border:solid windowtext 1.0pt" width="60" | '''HBOT 2.2 ATA'''
| style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | '''HBOT 2.4 ATA'''
| style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | '''Relative Risk Reduction'''
| style="width:76.5pt; border:solid windowtext 1.0pt" width="104" | '''Absolute Risk Reduction'''
| style="width:87.3pt; border:solid windowtext 1.0pt" width="119" | '''NNT'''
|-
| rowspan="2" style="width:68.4pt; border:solid windowtext 1.0pt" width="94" |
'''Complete or partial relief'''

| style="width:45.3pt; border:solid windowtext 1.0pt" width="64" | 1 month
| style="width:43.85pt; border:solid windowtext 1.0pt" width="60" | 0.50
| style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | 0.49
| style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | 2%
| style="width:76.5pt; border:solid windowtext 1.0pt" width="104" | 0.01
| style="width:87.3pt; border:solid windowtext 1.0pt" width="119" | 91
|-
| colspan="3" style="width:140.25pt; border:solid windowtext 1.0pt" width="191" | 95% CIs:
| style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | -18% to 23%
| style="width:76.5pt; border:solid windowtext 1.0pt" width="104" | -0.09 to 0.11
| style="width:87.3pt; border:solid windowtext 1.0pt" width="119" | NNT = 9 to INF; NNH = 11 to INF
|-
| rowspan="2" style="width:68.4pt; border:solid windowtext 1.0pt" width="94" |
'''No change in symptoms'''

| style="width:45.3pt; border:solid windowtext 1.0pt" width="64" | 1 month
| style="width:43.85pt; border:solid windowtext 1.0pt" width="60" | 0.50
| style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | 0.51
| style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | -2%
| style="width:76.5pt; border:solid windowtext 1.0pt" width="104" | -0.01
| style="width:87.3pt; border:solid windowtext 1.0pt" width="119" | -91
|-
| colspan="3" style="width:140.25pt; border:solid windowtext 1.0pt" width="191" | 95% CIs:
| style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | -23% to 18%
| style="width:76.5pt; border:solid windowtext 1.0pt" width="104" | -0.11 to 0.09
| style="width:87.3pt; border:solid windowtext 1.0pt" width="119" | NNT = 11 to INF; NNH = 9 to INF
|}

'''Comments:''' 1. The authors were primarily interested in the effect of pre-treatment expectations on resolution of symptoms and the RCT aspect was a relatively minor aim. 2. I have assumed '2.2 bar' here was in fact 2.2 ATA. 3. Pre-treatment expectations influenced the chance of improvement (positive expectation 60.3% improved; negative expectation 19% improved. P < 0.05). 4. Time to HBOT did not have any statistically significant influence on outcome. 5. On non-random analysis the authors concluded HBOT was not better than placebo treatment results.

'''Appraised by:'''Mike Bennett m.bennett@unsw.edu.,au ; Tuesday, 3 January 2023 '''Kill or Update By:''' January 2030

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 <span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:"><span style="color:black">There was no difference in the outcome from the treatment of tinnitus with two different hyperbaric oxygen regimens.</span></span>'''</span></span>
-{| class="Table" style="width:375.0pt; border:undefined" width="0"
+{| class="Table" style="width: 624px;" width="0"
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 <span style="line-height:normal">'''<span style="font-size:14.0pt"><span style="font-family:">Clinical Bottom Line:</span></span>'''</span>

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 <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">Lead author's name and fax:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">Christian Porubsky: christian.porubsky@klinikum-graz.at</span></span></span></span>
 <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">Three-part Clinical Question:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">For patients with tinnitus, does HBOT at 2.2 ATA for 60 mins daily for 15 days compared to a 2.5 ATA treatment on the same schedule result in any greater resolution of symptoms?<br/> '''Search Terms:''' tinnitus, hearing loss, retraining</span></span></span></span>
@@ Line 65: / Line 67: @@
 <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">Appraised by:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">Mike Bennett m.bennett@unsw.edu.au&nbsp;; Tuesday, 3 January 2023<br/> '''Kill or Update By:''' January 2030</span></span></span></span>
+<p style="text-align: center;">http://hboevidence.wikis.unsw.edu.au/images/8/89/Sumhorsa.gif</p> <p style="text-align: center;">&nbsp;</p> <p style="text-align: center;"><span style="font-size:xx-large;">[[Audiovestibular|BACK]]</span></p>

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 |}
-<span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Citation/s:</span></span></span>'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">1.Porubsky, C., Stiegler, P., Matzi, V., Lipp, C., Kontaxis, A., Klemen, H., Smolle-Jüttner, F. Hyperbaric oxygen in tinnitus: Influence of psychological factors on treatment results? ORL&nbsp;: Journal for Oto - Rhino - Laryngology and its Related Specialties,2007; 69(2):107-12.</span></span></span></span>
+<span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Citation/s:&nbsp;</span></span></span>'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">1. Porubsky, C., Stiegler, P., Matzi, V., Lipp, C., Kontaxis, A., Klemen, H., Smolle-Jüttner, F. Hyperbaric oxygen in tinnitus: Influence of psychological factors on treatment results? ORL&nbsp;: Journal for Oto - Rhino - Laryngology and its Related Specialties,2007; 69(2):107-12.</span></span></span></span>
 <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">Lead author's name and fax:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:black">Christian Porubsky: christian.porubsky@klinikum-graz.at</span></span></span></span>