http://hboevidence.wikis.unsw.edu.au/index.php?action=history&feed=atom&title=Steele
Steele - Revision history
2026-10-03T12:12:20Z
Revision history for this page on the wiki
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http://hboevidence.wikis.unsw.edu.au/index.php?title=Steele&diff=827&oldid=prev
M.bennett at 04:12, 15 November 2020
2020-11-15T04:12:52Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 04:12, 15 November 2020</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">No benefit from hyperbaric oxygen in amyotrophic lateral sclerosis</span>'''</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:">No benefit from hyperbaric oxygen in amyotrophic lateral sclerosis</span>'''</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Clinical Bottom Line:</span>'''</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Clinical Bottom Line:</span>'''</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">&nbsp;1. Both groups deteriorated at a similar rate.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">&nbsp;1. Both groups deteriorated at a similar rate.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Citation/s:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">1. Steele J, Zutchi D, Bradley WD. Negative results of a phase II study of hyperbaric oxygen therapy for amyotrophic leteral sclerosis. Amyotrophic Lateral Sclerosis 2007;8:274-275</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Citation/s:</span>'''<span style="font-family:">1. Steele J, Zutchi D, Bradley WD. Negative results of a phase II study of hyperbaric oxygen therapy for amyotrophic leteral sclerosis. Amyotrophic Lateral Sclerosis 2007;8:274-275</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="font-family: <del class="diffchange diffchange-inline">" times="" new="" roman",="" serif;"="</del>">'''Lead author's name and fax:''' Walter Bradley wbradley@med.miami.edu</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="font-family:">'''Lead author's name and fax:''' Walter Bradley wbradley@med.miami.edu</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Three-part Clinical Question:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">For patients with amyotrophic lateral sclerosis, does the administration of hyperbaric oxygen, compared to normal care, result in improved measures of ALS severity?</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Three-part Clinical Question:</span>'''<span style="font-family:">For patients with amyotrophic lateral sclerosis, does the administration of hyperbaric oxygen, compared to normal care, result in improved measures of ALS severity?</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Search Terms:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Amyotrohic lateral sclerosis;&nbsp;</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Search Terms:</span>'''<span style="font-family:">Amyotrohic lateral sclerosis;&nbsp;</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">The Study:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Single-blinded randomised controlled trial with intention-to-treat.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">The Study:</span>'''<span style="font-family:">Single-blinded randomised controlled trial with intention-to-treat.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">The Study Patients:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Patients meeting standard criteria for diagnosis of ALS and FVC >60% of expected.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">The Study Patients:</span>'''<span style="font-family:">Patients meeting standard criteria for diagnosis of ALS and FVC >60% of expected.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Control group (N = 5 ; 5&nbsp; analysed): 40 sessions of air breathing over 8 weeks for one hour daily at a maximum of 1.3 ATA.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">Control group (N = 5<ins class="diffchange diffchange-inline">&nbsp;</ins>; 5&nbsp; analysed): 40 sessions of air breathing over 8 weeks for one hour daily at a maximum of 1.3 ATA.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Experimental group (N = 5 ; 5&nbsp; analysed): As above but breathing 100% oxygen at 2 ATA.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">Experimental group (N = 5<ins class="diffchange diffchange-inline">&nbsp;</ins>; 5&nbsp; analysed): As above but breathing 100% oxygen at 2 ATA.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">The Evidence:</span>'''</span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">The Evidence:</span>'''</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family: <del class="diffchange diffchange-inline">" times="" new="" roman",="" serif;="" font-size:="" large;"="</del>">Authors report both groups deteriorated at similar rates with HBO group at 81.5% of baseline at 20 weeks and the sham group 89.2% of baseline at 12 weeks. No other quantitative results.</span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-family:">Authors report both groups deteriorated at similar rates with HBO group at 81.5% of baseline at 20 weeks and the sham group 89.2% of baseline at 12 weeks. No other quantitative results.</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">&nbsp;'''Comments:'''</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">&nbsp;'''Comments:'''</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">1. Study was of two groups of five patients with HBO or sham treatment with allocation by toss of coin.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">1. Study was of two groups of five patients with HBO or sham treatment with allocation by toss of coin.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">2. Patients were unaware of allocation when asked which group they were in.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">2. Patients were unaware of allocation when asked which group they were in.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">3. Study stopped early because there was no sign of slowed disease progression by 12 weeks analysis of the sham group and 20 weeks for the active group.</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">3. Study stopped early because there was no sign of slowed disease progression by 12 weeks analysis of the sham group and 20 weeks for the active group.</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Appraised by:</span>'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Mike Bennett&nbsp; m.bennett@unsw.edu.au ; Sunday, 15 November 2020</span></span></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Appraised by:</span>'''<span style="font-family:">Mike Bennett&nbsp; m.bennett@unsw.edu.au<ins class="diffchange diffchange-inline">&nbsp;</ins>; Sunday, 15 November 2020</span></span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:<del class="diffchange diffchange-inline">" times="" new="" roman",serif"="</del>">Kill or Update By:</span>'''<span style="font-family:" <del class="diffchange diffchange-inline">times</del>="" <del class="diffchange diffchange-inline">new</del>="" <del class="diffchange diffchange-inline">roman",serif"</del>=""><del class="diffchange diffchange-inline">&nbsp; November 2026</del><<del class="diffchange diffchange-inline">/</del>span></span></<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Kill or Update By:</span>'''<span style="font-family:"<ins class="diffchange diffchange-inline">>&nbsp; November 2026</span></span></span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p style</ins>="<ins class="diffchange diffchange-inline">text-align: center;</ins>"<ins class="diffchange diffchange-inline">>&nbsp;</p> <p style</ins>="<ins class="diffchange diffchange-inline">text-align: center;</ins>"<ins class="diffchange diffchange-inline">>[[File:Sumhorsa.gif|center|Sumhorsa.gif]]</p> <p style</ins>="<ins class="diffchange diffchange-inline">text-align: center;</ins>"><span <ins class="diffchange diffchange-inline">style="font-size:xx-large;"</ins>><ins class="diffchange diffchange-inline">[[Neuro_-_miscellaneous|BACK]]</ins></span></<ins class="diffchange diffchange-inline">p</ins>></div></td></tr>
</table>
M.bennett
http://hboevidence.wikis.unsw.edu.au/index.php?title=Steele&diff=824&oldid=prev
M.bennett: Created page with " <span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">No benefit from hyperbaric oxygen in amyotrop..."
2020-11-15T04:07:16Z
<p>Created page with " <span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">No benefit from hyperbaric oxygen in amyotrop..."</p>
<p><b>New page</b></p><div><br />
<span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">No benefit from hyperbaric oxygen in amyotrophic lateral sclerosis</span>'''</span></span><br />
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<span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">Clinical Bottom Line:</span>'''</span></span><br />
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<span style="font-size:large;"><span style="line-height:normal"><span style="font-family:" times="" new="" roman",serif"="">&nbsp;1. Both groups deteriorated at a similar rate.</span></span></span><br />
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<span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">Citation/s:</span>'''<span style="font-family:" times="" new="" roman",serif"="">1. Steele J, Zutchi D, Bradley WD. Negative results of a phase II study of hyperbaric oxygen therapy for amyotrophic leteral sclerosis. Amyotrophic Lateral Sclerosis 2007;8:274-275</span></span></span><br />
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<span style="font-size:large;"><span style="font-family: " times="" new="" roman",="" serif;"="">'''Lead author's name and fax:''' Walter Bradley wbradley@med.miami.edu</span></span><br />
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<span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">Three-part Clinical Question:</span>'''<span style="font-family:" times="" new="" roman",serif"="">For patients with amyotrophic lateral sclerosis, does the administration of hyperbaric oxygen, compared to normal care, result in improved measures of ALS severity?</span></span></span><br />
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<span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">Search Terms:</span>'''<span style="font-family:" times="" new="" roman",serif"="">Amyotrohic lateral sclerosis;&nbsp;</span></span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">The Study:</span>'''<span style="font-family:" times="" new="" roman",serif"="">Single-blinded randomised controlled trial with intention-to-treat.</span></span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">The Study Patients:</span>'''<span style="font-family:" times="" new="" roman",serif"="">Patients meeting standard criteria for diagnosis of ALS and FVC >60% of expected.</span></span></span><br />
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<span style="font-size:large;"><span style="line-height:normal"><span style="font-family:" times="" new="" roman",serif"="">Control group (N = 5 ; 5&nbsp; analysed): 40 sessions of air breathing over 8 weeks for one hour daily at a maximum of 1.3 ATA.</span></span></span><br />
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<span style="font-size:large;"><span style="line-height:normal"><span style="font-family:" times="" new="" roman",serif"="">Experimental group (N = 5 ; 5&nbsp; analysed): As above but breathing 100% oxygen at 2 ATA.</span></span></span><br />
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<span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><br />
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<span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">The Evidence:</span>'''</span></span><br />
<br />
<span style="font-family: " times="" new="" roman",="" serif;="" font-size:="" large;"="">Authors report both groups deteriorated at similar rates with HBO group at 81.5% of baseline at 20 weeks and the sham group 89.2% of baseline at 12 weeks. No other quantitative results.</span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><span style="font-size:large;"><span style="line-height:normal"><span style="font-family:" times="" new="" roman",serif"="">&nbsp;'''Comments:'''</span></span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal"><span style="font-family:" times="" new="" roman",serif"="">1. Study was of two groups of five patients with HBO or sham treatment with allocation by toss of coin.</span></span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal"><span style="font-family:" times="" new="" roman",serif"="">2. Patients were unaware of allocation when asked which group they were in.</span></span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal"><span style="font-family:" times="" new="" roman",serif"="">3. Study stopped early because there was no sign of slowed disease progression by 12 weeks analysis of the sham group and 20 weeks for the active group.</span></span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">Appraised by:</span>'''<span style="font-family:" times="" new="" roman",serif"="">Mike Bennett&nbsp; m.bennett@unsw.edu.au ; Sunday, 15 November 2020</span></span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal">&nbsp;</span></span><br />
<br />
<span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">Kill or Update By:</span>'''<span style="font-family:" times="" new="" roman",serif"="">&nbsp; November 2026</span></span></span></div>
M.bennett