Gordoben: Imported from Wikispaces

2018-12-28T04:05:24Z

Imported from Wikispaces

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'''Hyperbaric oxygen may improve healing following surgical treatment for osteoradionecrosis of the mandible.''' 

'''Clinical Bottom Line:''' 
1. No quantifiable evidence of improvement in osteoradionecrosis after the addition of hyperbaric oxygen to the treatment protocol. 

'''Appraised by:''' Mike Bennett, Dept of Diving and Hyperbaric Medicine, Prince of Wales Hospital 
Sydney; Friday, 11 June 1999 

'''Clinical Scenario:''' A patient with osteoradionecrosis of the mandible presented for surgical debridement. 
'''Three-part Question:''' In patients with established osteoradionecrosis, does the addition of hyperbaric oxygen to antibiotic and surgical measures to the treatment protocol result in improved resolution of the necrosis and improved wound healing? 
'''Search Terms''': osteoradionecrosis 

'''The Study:''' 
Double-blinded concealed randomised controlled trial intention-to-treat unknown. 
Patients with osteoradionecrosis of the mandible. No further details. 
'''Control group''' (N = 6; 0 analysed): Usual treatment protocol involving antibiotics, analgesics, wound irrigation, teeth extraction and sequestrectomies, plus 100% oxygen at 1.2ATA for 2 hours daily, five days each week for eight weeks. 
'''Experimental group''' (N = 6; 0 analysed): As above, but 100% oxygen exposure was at 2.0ATA on the same schedule 

'''The Evidence:''' 
"Healing process was better according to x-ray interpretation, clinical signs and symptoms, and soft tissue lesions." 

'''Comments:''' 
1. No statistical analysis of outcomes. The analysis was heralded but does not appear to have been published. 
2. Small study would have low power. 

'''Expiry date:''' December 2019
**References: '''
1. Tobey RE, Kelly JF. Osteoradionecrosis of the jaws. Otolaryngologic Clinics of North America 1979; 12:183-186 

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'''[[Radiation tissue injury | BACK]]'''

Tobey - Revision history

Gordoben: Imported from Wikispaces