M.bennett at 05:08, 30 September 2021

2021-09-30T05:08:00Z

Gordoben: Imported from Wikispaces

2018-06-17T01:55:44Z

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==Significant improvement in hearing for people with idiopathic sudden sensorineural hearing loss with the addition of hyperbaric oxygen==
**Clinical bottom line:'''
{|
| '''1. Significant improvement in hearing in 4 of 5 frequencies''' **2. Some evidence that HBOT is more effective with mild initial loss and in people under 50 years.'''
|-
|}
**Citation/s:'''Topuz E., Yigit O,Cinar U, Seven H. Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 2004, 261: 393-396
**Lead author's name and fax:''' O Yigit Fax: +90-212-2341121
**Three-part Clinical Question:''' Does the addition of a hyperbaric oxygen regimen to a standard medical treatment improve the hearing in people with acute idiopathic sudden sensorineural hearing loss (ISSHL).
**Search Terms:''' hyperbaric oxygenation, idiopathic sudden sensorineural hearing loss, ISSHL, hearing loss
**The Study:'''Non-blinded randomised controlled trial with intention-to-treat.
**The Study Patients:''' Sudden hearing loss of >30dB in at least 3 continguous pure tone frequencies. Less than 2 weeks since onset of symptoms. All were admitted to hospital.
**Control group''' (N = 21; 21 analysed): Prednisone 1mg/kg/day for 2 weeks, rheomacrodex 500mL/day for 5 days, diazepam 5mg twice a day (? duration), pentoxiphyllin 200mg iv twice a day (? duration).
**Experimental group''' (N = 30; 30 analysed): As above + hyperbaric oxygen 2.5ATA for 90 minutes twice a day over 5 days then 2.5ATA daily for 15 days.
**The Evidence:'''
{|
| '''Non-Event Outcomes''' || '''Time to outcome''' || '''Control group (?sd)''' || '''HBOT group (?sd)''' || '''P-value'''
|-
| Mean hearing gain all patients (dB) || 4 weeks || 17.4dB || 33.3dB || ?
|-
| Mean hearing gain by initial hearing levels (dB) <'''60 61-80 >'''80 || 4 weeks || 22.33 +/-9.311 6.18 +/-9.00 13.00 +/-6.58 || 22.53+/-12.68 35.45+/-22.09 50.70+/-21.54 || 0.758 0.014 0.005
|-
|}
**Comments:'''
1. There is no "functional" improvement assessment performed.
2. Intervals given above are not defined (probably standard deviations).
3. Results given for ‘34 ISSHL out of 30 patients’ in the HBOT group. Meaning not clear.
4. Only age and sex were considered as possible confounders, no other patient data.
5. No indication of loss to recruitment or attempt to recruit consecutive patients.
**Appraised by''': Dr Glen Hawkins, Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, NSW, AUSTRALIA; Thursday, 10 March 2005Email: [[mailto:hawkeye@swiftdsl.com.au | hawkeye@swiftdsl.com.au]]
**Kill or Update By:''' June 2020

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Topuz - Revision history

M.bennett at 05:08, 30 September 2021

Gordoben: Imported from Wikispaces