M.bennett at 03:14, 7 February 2022

2022-02-07T03:14:40Z

M.bennett at 02:55, 7 February 2022

2022-02-07T02:55:47Z

M.bennett: Created page with " '''A single hyperbaric oxygen exposure may reduce inflammatory and m..."

2022-02-07T02:54:22Z

Created page with " '''A single hyperbaric oxygen exposure may reduce inflammatory and m..."

New page

'''A single hyperbaric oxygen exposure may reduce inflammatory and muscle damage markers following exercise in normal conditions.'''

 

'''Clinical bottom line:'''

#Clinical significance unclear.
#Post-exercise HBO exposure may reduce markers of inflammation and muscle damage, but results uncertain.
#Also some modest reduction in oxidative stress possible.
#Described as a pilot study, but plans for the definitive study remain vague.

 

----

'''Citation: '''Woo J, Min JH, Lee YH, Roh HT. Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study. International Journal of Environmental Research and Public Health. 2020 October 17:7377.

 

'''Lead author’s name and email: '''Jinhee Woo : jop9508@naver.com

 

'''Three-part clinical question: '''For individuals exercising in either air or hypobaric hypoxic environments, does a later rest period breathing hyperbaric oxygen, compared to air, result in reduced serum inflammatory, oxidative and muscle damage markers?

 '''Search terms: '''Exercise, oxidative stress, muscle damage

 

'''The study: '''Non-blinded randomised controlled trial with intention-to-treat.

'''The study patients: '''Healthy male volunteers with BMI under 30 kg/m2.

 '''Control group: '''(N = 6; 6 analysed): Treadmill run for 60 minutes at 75-80% max heart rate breathing air at 1  (PiO2 = 0.2 ATA) followed by air breathing rest for 60 minutes.

 '''Experimental group: '''(N = 6; 6 analysed): As above for exercise, but breathing 100% oxygen at 2.5 ATA for 60 minutes.

 

'''The evidence'''

{| class="Table" style="border:solid windowtext 1.0pt"
|-
| rowspan="2" style="border: 1pt solid windowtext; width: 357px;" | '''Measure'''
| colspan="2" style="border: 1pt solid windowtext; width: 133px;" | '''Air Group'''
| colspan="2" style="border: 1pt solid windowtext; width: 121px;" | '''HBO Group'''
| rowspan="2" style="border: 1pt solid windowtext; width: 88px;" | '''Difference'''
| rowspan="2" style="border: 1pt solid windowtext; width: 138px;" | '''95% CI'''
|-
| style="border: 1pt solid windowtext; width: 61px;" | '''Mean'''
| style="border: 1pt solid windowtext; width: 65px;" | '''SD'''
| style="border: 1pt solid windowtext; width: 57px;" | '''Mean'''
| style="border: 1pt solid windowtext; width: 57px;" | '''SD'''
|-
| style="border: 1pt solid windowtext; width: 357px;" |
'''Interleukin-6 (pg/ml at 60 mins)'''

| style="border: 1pt solid windowtext; width: 61px;" | 911
| style="border: 1pt solid windowtext; width: 65px;" | 111
| style="border: 1pt solid windowtext; width: 57px;" | 900
| style="border: 1pt solid windowtext; width: 57px;" | 53
| style="border: 1pt solid windowtext; width: 88px;" | 11
| style="border: 1pt solid windowtext; width: 138px;" | -9720 to 9742
|-
| style="border: 1pt solid windowtext; width: 357px;" |
'''Biological antioxidant potential (BAP) (micromole/L at 60 mins)'''

| style="border: 1pt solid windowtext; width: 61px;" | 2773
| style="border: 1pt solid windowtext; width: 65px;" | 182
| style="border: 1pt solid windowtext; width: 57px;" | 2545
| style="border: 1pt solid windowtext; width: 57px;" | 227
| style="border: 1pt solid windowtext; width: 88px;" | 228
| style="border: 1pt solid windowtext; width: 138px;" | -54217 to 54673
|-
| style="border: 1pt solid windowtext; width: 357px;" |
'''Creatine Kinase (u/L)'''

| style="border: 1pt solid windowtext; width: 61px;" | 255
| style="border: 1pt solid windowtext; width: 65px;" | 59
| style="border: 1pt solid windowtext; width: 57px;" | 227
| style="border: 1pt solid windowtext; width: 57px;" | 64
| style="border: 1pt solid windowtext; width: 88px;" | 28
| style="border: 1pt solid windowtext; width: 138px;" | -4844 to 4900
|}

Note: Interleukin-6 used as marker of inflammation, BAP as a measure of oxidative stress, CK as an indicator of muscle damage

'''Comments:'''

#Clinical significance of the findings is not clear.
#Authors also tested a group exercising in hypoxia (PiO2 = 0.1 ATA) and then recovered in HBO conditions. Not discussed here.
#All outcome data here is read from graphical display of results. The report is rather confusing.

 

'''Appraised by'''

Bosco Tran [mailto:bosco.tran@student.unsw.edu.au bosco.tran@student.unsw.edu.au]

 Kill or update by: February 2025

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 #<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Clinical significance unclear.</span></span>
 #<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Post-exercise HBO exposure may reduce markers of inflammation and muscle damage, but results uncertain.</span></span>
-#<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Also some modest reduction in oxidative stress possible.</span></span>
+#<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Also some modest reduction in oxidative stress possible.</span></span><span style="line-height:107%">&nbsp;</span>
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 <span style="line-height:107%">&nbsp;</span>
-<span style="line-height:107%">'''Lead author’s name and email: '''Jinhee Woo : jop9508@naver.com</span>
+<span style="line-height:107%">'''Lead author’s name and email: '''Jinhee Woo&nbsp;: jop9508@naver.com</span>
 <span style="line-height:107%">&nbsp;</span>
@@ Line 92: / Line 89: @@
 #Authors also tested a group exercising in hypoxia (PiO2 = 0.1 ATA) and then recovered in HBO conditions. Not discussed here.
 #All outcome data here is read from graphical display of results. The report is rather confusing.
 &nbsp;
-<span style="line-height:107%">'''Appraised by'''</span>
+<span style="line-height:107%">'''Appraised by:&nbsp;'''</span><span style="line-height:107%">Bosco Tran [mailto:bosco.tran@student.unsw.edu.au bosco.tran@student.unsw.edu.au]</span>
-<span style="line-height:107%">&nbsp;Kill or update by: February 2025</span>
+<span style="line-height:107%">'''Kill or update by''': February 2025</span>

Woo - Revision history

M.bennett at 03:14, 7 February 2022

M.bennett at 02:55, 7 February 2022

M.bennett: Created page with " '''A single hyperbaric oxygen exposure may reduce inflammatory and m..."