Difference between revisions of "Xu2017"
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{| class="Table" style="border: 1pt solid windowtext; width: 719px;" | {| class="Table" style="border: 1pt solid windowtext; width: 719px;" | ||
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| − | | style="width: 167px; border: 1pt solid windowtext;" width="138" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 167px; border: 1pt solid windowtext;" width="138" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Outcome</span></span>'''</span></p> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Time to Outcome</span></span>'''</span></p> |
| − | | style="width: 63px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 63px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">1.5 ATA group</span></span>'''</span></p> |
| − | | style="width: 78px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 78px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">2.5 ATA group</span></span>'''</span></p> |
| − | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Relative risk reduction</span></span>'''</span></p> |
| − | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Absolute risk reduction</span></span>'''</span></p> |
| − | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">NNT</span></span>'''</span></p> |
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| rowspan="2" style="width: 167px; border: 1pt solid windowtext;" width="138" | | | rowspan="2" style="width: 167px; border: 1pt solid windowtext;" width="138" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Modified Rankin Score </= 1 (Good outcome)</span></span>'''</span> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">6 months</span></span></span></p> |
| − | | style="width: 63px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 63px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">.69</span></span></span></p> |
| − | | style="width: 78px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 78px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">.89</span></span></span></p> |
| − | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">30%</span></span></span></p> |
| − | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.2</span></span></span></p> |
| − | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">5</span></span></span></p> |
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| − | | colspan="3" style="width: 236px; border: 1pt solid windowtext;" width="225" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | colspan="3" style="width: 236px; border: 1pt solid windowtext;" width="225" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">95% CIs:</span></span></span></p> |
| − | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">3% to 57%</span></span></span></p> |
| − | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.02 to 0.39</span></span></span></p> |
| − | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">3 to 44</span></span></span></p> |
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| rowspan="2" style="width: 167px; border: 1pt solid windowtext;" width="138" | | | rowspan="2" style="width: 167px; border: 1pt solid windowtext;" width="138" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">NIHSS </= 2 (Good outcome)</span></span>'''</span> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">6 months</span></span></span></p> |
| − | | style="width: 63px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 63px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">.56</span></span></span></p> |
| − | | style="width: 78px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 78px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">.81</span></span></span></p> |
| − | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">44%</span></span></span></p> |
| − | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.25</span></span></span></p> |
| − | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">4</span></span></span></p> |
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| − | | colspan="3" style="width: 236px; border: 1pt solid windowtext;" width="225" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | colspan="3" style="width: 236px; border: 1pt solid windowtext;" width="225" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">95% CIs:</span></span></span></p> |
| − | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 100px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">7% to 80%</span></span></span></p> |
| − | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 86px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.04 to 0.45</span></span></span></p> |
| − | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 89px; border: 1pt solid windowtext;" width="60" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">2 to 24</span></span></span></p> |
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| rowspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"> </p> | | rowspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"> </p> | ||
| − | | colspan="2" style="width: 157px; border: 1pt solid windowtext;" width="106" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | colspan="2" style="width: 157px; border: 1pt solid windowtext;" width="106" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">1.5 ATA Group</span></span>'''</span></p> |
| − | | colspan="2" style="width: 122px; border: 1pt solid windowtext;" width="99" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | colspan="2" style="width: 122px; border: 1pt solid windowtext;" width="99" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">2.5 ATA Group</span></span>'''</span></p> |
| − | | rowspan="2" style="width: 110px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | rowspan="2" style="width: 110px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Difference</span></span>'''</span></p> |
| − | | rowspan="2" style="width: 93px; border: 1pt solid windowtext;" width="82" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | rowspan="2" style="width: 93px; border: 1pt solid windowtext;" width="82" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">95% CI</span></span>'''</span></p> |
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| − | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Mean</span></span>'''</span></p> |
| − | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">SD</span></span>'''</span></p> |
| − | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Mean</span></span>'''</span></p> |
| − | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">SD</span></span>'''</span></p> |
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| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Fasting blood sugar (mmol/L) at 1 month</span></span>'''</span> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">10.9</span></span></span></p> |
| − | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.93</span></span></span></p> |
| − | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">9.6</span></span></span></p> |
| − | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.81</span></span></span></p> |
| − | | style="width: 110px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 110px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.3</span></span></span></p> |
| − | | style="width: 93px; border: 1pt solid windowtext;" width="82" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 93px; border: 1pt solid windowtext;" width="82" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.96 to 1.64</span></span></span></p> |
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| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">HbA1c (%) at 1 month</span></span>'''</span> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">8.8</span></span></span></p> |
| − | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.92</span></span></span></p> |
| − | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">7.8</span></span></span></p> |
| − | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.8</span></span></span></p> |
| − | | style="width: 110px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 110px; border: 1pt solid windowtext;" width="74" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.0</span></span></span></p> |
| − | | style="width: 93px; border: 1pt solid windowtext;" width="82" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 93px; border: 1pt solid windowtext;" width="82" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.67 to 1.33</span></span></span></p> |
|- | |- | ||
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Insulin (microU/ml) at one month</span></span>'''</span> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="56" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">19.4</span></span></span></p> |
| − | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 68px; border: 1pt solid windowtext;" width="48" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.75</span></span></span></p> |
| − | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 66px; border: 1pt solid windowtext;" width="52" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">17.8</span></span></span></p> |
| − | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width: 79px; border: 1pt solid windowtext;" width="45" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.31</span></span></span></p> |
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Latest revision as of 01:04, 22 July 2021
Hyperbaric oxygen therapy improved the proportion good outcomes in diabetic patients following haemorrhagic stroke
|
1. More individuals who had HBOT were deemed to have a good outcome at six months following the haemorrhagic stroke |
Citation/s:1. Xu Q, Fan SB, Wan YL, Liu XL, Wang L. The potential long-term neurological improvement of early hyperbaric oxygen therapy on haemorrhagic stroke in the diabetics. Diabetes research and clinical practice. 2018 Apr 1;138:75-80.
Lead author's name and fax: xuqian6521@126.com
Three-part Clinical Question:For patients with diabetes and suffering a haemorrhagic stroke, does the application of hyperbaric oxygen improve outcome?
Search Terms: intracerebral haemorrhage; stroke; diabetes
The Study:Double-blinded concealed randomised controlled trial with intention-to-treat.
The Study Patients: Adult patients with a history of diabetes and presenting to the emergency department within 24 hours of a CT-confirmed haemorrhagic stroke. Excluded if severe (NIHSS >22) or died over the next six months.
Control group (N = 32; 32 analysed): All standard care plus air breathing in a chamber at 1.5 ATA for 60 minutes daily for 30 days.
Experimental group (N = 47; 47 analysed): As above but breathing 100% oxygen at 2.5 ATA.
The Evidence:
Outcome |
Time to Outcome |
1.5 ATA group |
2.5 ATA group |
Relative risk reduction |
Absolute risk reduction |
NNT |
|
Modified Rankin Score </= 1 (Good outcome) |
6 months |
.69 |
.89 |
30% |
0.2 |
5 |
95% CIs: |
3% to 57% |
0.02 to 0.39 |
3 to 44 | |||
|
NIHSS </= 2 (Good outcome) |
6 months |
.56 |
.81 |
44% |
0.25 |
4 |
95% CIs: |
7% to 80% |
0.04 to 0.45 |
2 to 24 | |||
|
1.5 ATA Group |
2.5 ATA Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Fasting blood sugar (mmol/L) at 1 month |
10.9 |
0.93 |
9.6 |
0.81 |
1.3 |
0.96 to 1.64 |
|
HbA1c (%) at 1 month |
8.8 |
0.92 |
7.8 |
0.8 |
1.0 |
0.67 to 1.33 |
|
Insulin (microU/ml) at one month |
19.4 |
1.75 |
17.8 |
1.31 |
1.6 |
0.57 to 2.63 |
Comments:
1. Intriguing study with interesting outcomes. It should be reproduced elsewhere sooner rather than later as the results seem very important
2. Note planned retrospective exclusion of patients who died within 6 months, but none died.
3. Patients were randomised on a 1 Control :1.5 HBO schedule.
4. Modified Rankin <2 is no symptoms or no significant disability, NIHSS <3 similar and Barthel Index suggests fully independent functioning
Appraised by: Mike Bennett m.bennett@unsw.edu.au; Thursday, 23 January 2020
Kill or Update By: January 2023
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