Difference between revisions of "Schoen"
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<span style="font-size:large;">'''Search Terms: '''Late radiation injury; dental implants; prevention</span> '''<span style="font-family:">The Study:</span>'''<span style="font-size: large; font-family:">Non-blinded randomised controlled trial with intention-to-treat.</span> | <span style="font-size:large;">'''Search Terms: '''Late radiation injury; dental implants; prevention</span> '''<span style="font-family:">The Study:</span>'''<span style="font-size: large; font-family:">Non-blinded randomised controlled trial with intention-to-treat.</span> | ||
| − | <span style="font-size:large;">'''<span style="font-family:">The Study Patients: </span>'''<span style="font-family:">Edentulous patients with past radiotherapy for head and neck malignancy and who required dental implants for prosthodontic rehabilitation.</span></span> | + | <span style="font-size:large;">'''<span style="font-family:">The Study Patients: </span>'''<span style="font-family:">Edentulous patients with past radiotherapy for head and neck malignancy and who required dental implants for prosthodontic rehabilitation.</span></span> |
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| + | <span style="font-size:large;"><span style="font-family:">Control group (N = 13; 13 analysed): Peri-operative broad spectrum antibiotics one day before and for two weeks after the placement of dental implants.</span></span> | ||
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| + | <span style="font-size:large;"><span style="font-family:">Experimental group (N = 13; 13 analysed): As above, plus 100% oxygen breathing at 2.5 ATA for 80 minutes daily 20 times pre-implantation and 10 after.</span></span> | ||
<span style="font-size:large;">'''The Evidence:'''</span> | <span style="font-size:large;">'''The Evidence:'''</span> | ||
| − | {| class="Table" style="border: | + | |
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| + | {| class="Table" style="border:solid windowtext 1.0pt" | ||
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| − | | style="width:89.55pt" width="122" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Outcome</span></span>'''</span></p> | + | | style="width:89.55pt; border:solid windowtext 1.0pt" width="122" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Outcome</span></span>'''</span></p> |
| − | | style="width:41.9pt" width="58" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Time to Outcome</span></span>'''</span></p> | + | | style="width:41.9pt; border:solid windowtext 1.0pt" width="58" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Time to Outcome</span></span>'''</span></p> |
| − | | style="width:47.2pt" width="65" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Control group</span></span>'''</span></p> | + | | style="width:47.2pt; border:solid windowtext 1.0pt" width="65" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Control group</span></span>'''</span></p> |
| − | | style="width:41.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">HBO group</span></span>'''</span></p> | + | | style="width:41.0pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">HBO group</span></span>'''</span></p> |
| − | | style="width:69.4pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Relative Risk Reduction</span></span>'''</span></p> | + | | style="width:69.4pt; border:solid windowtext 1.0pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Relative Risk Reduction</span></span>'''</span></p> |
| − | | style="width:69.35pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Absolute Risk Reduction</span></span>'''</span></p> | + | | style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Absolute Risk Reduction</span></span>'''</span></p> |
| − | | style="width:90.65pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">NNT</span></span>'''</span></p> | + | | style="width:90.65pt; border:solid windowtext 1.0pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">NNT</span></span>'''</span></p> |
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| − | | rowspan="2" style="width:89.55pt" width="122" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Number of patients with at least one lost implant</span></span>'''</span></p> | + | | rowspan="2" style="width:89.55pt; border:solid windowtext 1.0pt" width="122" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Number of patients with at least one lost implant</span></span>'''</span></p> |
| − | | style="width:41.9pt" width="58" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1 year</span></span></span></p> | + | | style="width:41.9pt; border:solid windowtext 1.0pt" width="58" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">1 year</span></span></span></p> |
| − | | style="width:47.2pt" width="65" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.15</span></span></span></p> | + | | style="width:47.2pt; border:solid windowtext 1.0pt" width="65" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">0.15</span></span></span></p> |
| − | | style="width:41.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.39</span></span></span></p> | + | | style="width:41.0pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">0.39</span></span></span></p> |
| − | | style="width:69.4pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-150%</span></span></span></p> | + | | style="width:69.4pt; border:solid windowtext 1.0pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-150%</span></span></span></p> |
| − | | style="width:69.35pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-0.23</span></span></span></p> | + | | style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-0.23</span></span></span></p> |
| − | | style="width:90.65pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">4</span></span></span></p> | + | | style="width:90.65pt; border:solid windowtext 1.0pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">4</span></span></span></p> |
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| − | | colspan="3" style="width:133.1pt" width="179" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">95% CIs:</span></span></span></p> | + | | colspan="3" style="width:133.1pt; border:solid windowtext 1.0pt" width="179" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">95% CIs:</span></span></span></p> |
| − | | style="width:69.4pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-364% to 64%</span></span></span></p> | + | | style="width:69.4pt; border:solid windowtext 1.0pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-364% to 64%</span></span></span></p> |
| − | | style="width:69.35pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-0.56 to 0.10</span></span></span></p> | + | | style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-0.56 to 0.10</span></span></span></p> |
| − | | style="width:90.65pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">NNT = 2 to INF; NNH = 10 to INF</span></span></span></p> | + | | style="width:90.65pt; border:solid windowtext 1.0pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">NNT = 2 to INF; NNH = 10 to INF</span></span></span></p> |
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| − | | rowspan="2" style="width:89.55pt" width="122" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Development of osteoradionecrosis</span></span>'''</span></p> | + | | rowspan="2" style="width:89.55pt; border:solid windowtext 1.0pt" width="122" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Development of osteoradionecrosis</span></span>'''</span></p> |
| − | | style="width:41.9pt" width="58" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1 year</span></span></span></p> | + | | style="width:41.9pt; border:solid windowtext 1.0pt" width="58" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">1 year</span></span></span></p> |
| − | | style="width:47.2pt" width="65" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0</span></span></span></p> | + | | style="width:47.2pt; border:solid windowtext 1.0pt" width="65" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">0</span></span></span></p> |
| − | | style="width:41.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">0.08</span></span></span></p> | + | | style="width:41.0pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">0.08</span></span></span></p> |
| − | | style="width:69.4pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">INF</span></span></span></p> | + | | style="width:69.4pt; border:solid windowtext 1.0pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">INF</span></span></span></p> |
| − | | style="width:69.35pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-0.08</span></span></span></p> | + | | style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-0.08</span></span></span></p> |
| − | | style="width:90.65pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">13</span></span></span></p> | + | | style="width:90.65pt; border:solid windowtext 1.0pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">13</span></span></span></p> |
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| − | | colspan="3" style="width:133.1pt" width="179" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">95% CIs:</span></span></span></p> | + | | colspan="3" style="width:133.1pt; border:solid windowtext 1.0pt" width="179" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">95% CIs:</span></span></span></p> |
| − | | style="width:69.4pt; padding:.75pt .75pt .75pt .75pt" width="95" | | + | | style="width:69.4pt; border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" width="95" | |
| − | | style="width:69.35pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-0.22 to 0.07</span></span></span></p> | + | | style="width:69.35pt; border:solid windowtext 1.0pt" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-0.22 to 0.07</span></span></span></p> |
| − | | style="width:90.65pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">NNT = 5 to INF; NNH = 15 to INF</span></span></span></p> | + | | style="width:90.65pt; border:solid windowtext 1.0pt" width="124" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">NNT = 5 to INF; NNH = 15 to INF</span></span></span></p> |
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| − | {| class="Table" style="border: | + | {| class="Table" style="border:solid windowtext 1.0pt" |
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| − | | rowspan="2" style="width:174.55pt" width="236" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Measure</span></span>'''</span></p> | + | | rowspan="2" style="width:174.55pt; border:solid windowtext 1.0pt" width="236" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Measure</span></span>'''</span></p> |
| − | | colspan="2" style="width:83.55pt" width="113" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Control Group</span></span>'''</span></p> | + | | colspan="2" style="width:83.55pt; border:solid windowtext 1.0pt" width="113" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Control Group</span></span>'''</span></p> |
| − | | colspan="2" style="width:90.65pt" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Hyperbaric Group</span></span>'''</span></p> | + | | colspan="2" style="width:90.65pt; border:solid windowtext 1.0pt" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Hyperbaric Group</span></span>'''</span></p> |
| − | | rowspan="2" style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Difference</span></span>'''</span></p> | + | | rowspan="2" style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Difference</span></span>'''</span></p> |
| − | | rowspan="2" style="width:55.2pt" width="77" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">95% CI</span></span>'''</span></p> | + | | rowspan="2" style="width:55.2pt; border:solid windowtext 1.0pt" width="77" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">95% CI</span></span>'''</span></p> |
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| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Mean</span></span>'''</span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Mean</span></span>'''</span></p> |
| − | | style="width:33.95pt" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">SD</span></span>'''</span></p> | + | | style="width:33.95pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">SD</span></span>'''</span></p> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Mean</span></span>'''</span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Mean</span></span>'''</span></p> |
| − | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">SD</span></span>'''</span></p> | + | | style="width:41.05pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">SD</span></span>'''</span></p> |
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| − | | style="width:174.55pt" width="236" | | + | | style="width:174.55pt; border:solid windowtext 1.0pt" width="236" | |
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Oral Health Impact Profile (0 best to 36 worst) at one year</span></span>'''</span> | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Oral Health Impact Profile (0 best to 36 worst) at one year</span></span>'''</span> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">12.7</span></span></span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">12.7</span></span></span></p> |
| − | | style="width:33.95pt" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">9.7</span></span></span></p> | + | | style="width:33.95pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">9.7</span></span></span></p> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">15.0</span></span></span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">15.0</span></span></span></p> |
| − | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">7.3</span></span></span></p> | + | | style="width:41.05pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">7.3</span></span></span></p> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">2.3</span></span></span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">2.3</span></span></span></p> |
| − | | style="width:55.2pt" width="77" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-4.7 to 9.3</span></span></span></p> | + | | style="width:55.2pt; border:solid windowtext 1.0pt" width="77" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-4.7 to 9.3</span></span></span></p> |
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| − | | style="width:174.55pt" width="236" | | + | | style="width:174.55pt; border:solid windowtext 1.0pt" width="236" | |
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Gronigen Activity Restriction Scale Dentistry (0 best to 22 worst) at 1 year</span></span>'''</span> | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">Gronigen Activity Restriction Scale Dentistry (0 best to 22 worst) at 1 year</span></span>'''</span> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">4.3</span></span></span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">4.3</span></span></span></p> |
| − | | style="width:33.95pt" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">7.4</span></span></span></p> | + | | style="width:33.95pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">7.4</span></span></span></p> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">5.3</span></span></span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">5.3</span></span></span></p> |
| − | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">5.5</span></span></span></p> | + | | style="width:41.05pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">5.5</span></span></span></p> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.90</span></span></span></p> | + | | style="width:48.1pt; border:solid windowtext 1.0pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">1.90</span></span></span></p> |
| − | | style="width:55.2pt" width="77" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-4.3 to 6.3</span></span></span></p> | + | | style="width:55.2pt; border:solid windowtext 1.0pt" width="77" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-4.3 to 6.3</span></span></span></p> |
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Latest revision as of 03:28, 9 July 2019
Hyperbaric oxygen therapy did not improve outcome in irradiated patients requiring mandibular surgical implants for dental reconstruction
Clinical bottom line:
1. Peri-implant hyperbaric oxygen for dental implants into irradiated tissue did not improve the outcome.
2. HBO is not justified in these patients
Citation/s:1. Schoen PJ, Raghoebar GM, Bouma J, Reintsema H, Vissink A, Sterk W, Roodenburg JLN. Rehabilitation of oral function in head and neck cancer patients after radiotherapy with implant-retained dentures: Effects of hyperbaric oxygen therapy. Oral Oncology 2007;43:379-388
Lead author's name and fax: Pieter Schoen p.j.schoen@hccnet.nl
Three-part Clinical Question: For patients who have been irradiated in the area, does a course of hyperbaric oxygen, result in more successful placement of lower jaw implants for denture rehabilitation?
Search Terms: Late radiation injury; dental implants; prevention The Study:Non-blinded randomised controlled trial with intention-to-treat.
The Study Patients: Edentulous patients with past radiotherapy for head and neck malignancy and who required dental implants for prosthodontic rehabilitation.
Control group (N = 13; 13 analysed): Peri-operative broad spectrum antibiotics one day before and for two weeks after the placement of dental implants.
Experimental group (N = 13; 13 analysed): As above, plus 100% oxygen breathing at 2.5 ATA for 80 minutes daily 20 times pre-implantation and 10 after.
The Evidence:
Outcome |
Time to Outcome |
Control group |
HBO group |
Relative Risk Reduction |
Absolute Risk Reduction |
NNT |
Number of patients with at least one lost implant |
1 year |
0.15 |
0.39 |
-150% |
-0.23 |
4 |
95% CIs: |
-364% to 64% |
-0.56 to 0.10 |
NNT = 2 to INF; NNH = 10 to INF | |||
Development of osteoradionecrosis |
1 year |
0 |
0.08 |
INF |
-0.08 |
13 |
95% CIs: |
-0.22 to 0.07 |
NNT = 5 to INF; NNH = 15 to INF | ||||
Measure |
Control Group |
Hyperbaric Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Oral Health Impact Profile (0 best to 36 worst) at one year |
12.7 |
9.7 |
15.0 |
7.3 |
2.3 |
-4.7 to 9.3 |
|
Gronigen Activity Restriction Scale Dentistry (0 best to 22 worst) at 1 year |
4.3 |
7.4 |
5.3 |
5.5 |
1.90 |
-4.3 to 6.3 |
Comments:
1. No power or sample size calculations were made - may be underpowered to find a clinically important difference.
2. No differences between groups in radiologic appearance or mouth dryness.
3. All results are given in text and tables as 'xx +/- yy', but there is no indication what this means. The statistical analysis section implies all data sets were analyzed using non-parametric tests. We have calculated the results here as if what was meant was mean and sd.
4. An open label study.
5. Neither group showed major improvements in quality of life scores.
Appraised by: Mike Bennett m.bennett@unsw.edu.au ; Monday, 17 June 2019
Kill or Update By: June 2022
