Difference between revisions of "Wahl"
(Created page with " <span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:" times="" new="" roman",serif"="">A single session of hyperbaric oxygen produce...") |
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| − | <span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:x-large;"><span style="line-height:normal">'''<span style="font-family:">A single session of hyperbaric oxygen produces a protective effect against hyperalgesia that persisted for at least a month.</span>'''</span></span> |
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| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Clinical Bottom Line:</span>'''</span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">1. Hyperbaric oxygen following an experimental burn injury produced a reduced area of secondary hyperalgesia.</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">2. This effect persisted for at least one month. No changes were seen after air breathing control subjects.</span></span></span> |
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| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Citation/s:</span>'''<span style="font-family:">1.Wahl AM, Bidstrup D, Smidt-Nielsen IG, Werner MU, Hyldegaard O, Rotbøll-Nielsen P. A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial. Journal of pain research. 2019;12:2337.</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Lead author's name and email:</span>'''<span style="font-family:">Anna Wahl Annamygd@gmail.com</span></span></span> |
<span style="font-size:large;"><span style="line-height:normal"> </span></span> | <span style="font-size:large;"><span style="line-height:normal"> </span></span> | ||
| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Three-part Clinical Question:</span>'''<span style="font-family:"> For volunteers undergoing an experimental burn injury, does hyperbaric oxygen exposure compared to air breathing result in protection from subsequent hyperalgesia?</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Search Terms:</span>'''<span style="font-family:"> Thermal burn, nociception, hyperalgesia</span></span></span> |
<span style="font-size:large;"><span style="line-height:normal"> </span></span> | <span style="font-size:large;"><span style="line-height:normal"> </span></span> | ||
| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">The Study:</span>'''<span style="font-family:">Single-blinded concealed randomised controlled trial with intention-to-treat.</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">The Study Patients:</span>'''<span style="font-family:"> Healthy volunteers having an experimenat first degree burn injury applied to the lower limb. Same injury as Rasmussen 2015. Trial was crossed over after a minimum of 28 days.</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">Control group (N = 22; 19 analysed): Air breathing at 1 ATA</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">Experimental group (N = 20; 19 analysed): One session of breathing 100% oxygen at 2.4 ATA for 90 minutes</span></span></span> |
<span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"> </span></span> | <span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"> </span></span> | ||
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{| class="MsoTableGrid" style="width:453.35pt; border-collapse:collapse; border:solid windowtext 1.0pt" width="604" | {| class="MsoTableGrid" style="width:453.35pt; border-collapse:collapse; border:solid windowtext 1.0pt" width="604" | ||
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| − | | rowspan="2" style="width:142.75pt; border:solid windowtext 1.0pt" width="190" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | rowspan="2" style="width:142.75pt; border:solid windowtext 1.0pt" width="190" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">Outcome</span></span>'''</span></span></p> |
| − | | colspan="2" style="width:105.1pt; border:solid windowtext 1.0pt; border-left:none" width="140" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | colspan="2" style="width:105.1pt; border:solid windowtext 1.0pt; border-left:none" width="140" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">Air breathing control</span></span>'''</span></span></p> |
| − | | colspan="2" style="width:3.0cm; border:solid windowtext 1.0pt; border-left:none" width="113" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | colspan="2" style="width:3.0cm; border:solid windowtext 1.0pt; border-left:none" width="113" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">Hyperbaric oxygen</span></span>'''</span></span></p> |
| − | | style="width: 165px; border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none;" width="85" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 165px; border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none;" width="85" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">Difference</span></span>'''</span></span></p> |
| − | | style="width: 18px; border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none;" width="75" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 18px; border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none;" width="75" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">P-value*</span></span>'''</span></span></p> |
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| − | | style="width:62.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="83" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width:62.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="83" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">Mean</span></span>'''</span></span></p> |
| − | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">SD</span></span>'''</span></span></p> |
| − | | style="width: 107px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="76" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 107px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="76" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">Mean</span></span>'''</span></span></p> |
| − | | style="width: 1px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="38" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 1px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="38" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">SD</span></span>'''</span></span></p> |
| − | | rowspan="2" style="width: 165px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="85" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"> </p> <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family: | + | | rowspan="2" style="width: 165px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="85" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"> </p> <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family:">13.2</span></span></span></span></p> |
| − | | rowspan="2" style="width: 18px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="75" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"> </p> <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family: | + | | rowspan="2" style="width: 18px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="75" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"> </p> <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family:">0.02</span></span></span></span></p> |
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| style="width:142.75pt; border:solid windowtext 1.0pt; border-top:none" width="190" | | | style="width:142.75pt; border:solid windowtext 1.0pt; border-top:none" width="190" | | ||
| − | <span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt">'''<span style="font-size:12.0pt"><span style="font-family:">Secondary hyperalgesic area after injury (cm-sq)</span></span>'''</span></span> |
| − | | style="width:62.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="83" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:62.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="83" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family:">32.0</span></span></span></span></p> |
| − | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family:">11.9</span></span></span></span></p> |
| − | | style="width: 107px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="76" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 107px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="76" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family:">18.8</span></span></span></span></p> |
| − | | style="width: 1px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="38" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 1px; border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext;" width="38" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:0cm 5.4pt 0cm 5.4pt"><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family:">8.3</span></span></span></span></p> |
|} | |} | ||
| − | <span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"> </span></span><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"> </span></span><span style="line-height:normal"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-size:12.0pt"><span style="font-family:"> *Taken from paper – no 95% CI calculatable,</span></span></span></span> |
<span style="font-size:large;"><span style="line-height:normal"> </span></span> | <span style="font-size:large;"><span style="line-height:normal"> </span></span> | ||
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:"> '''Comments:'''</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">1. Crossover design with examiner blinding to allocation.</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">2. 26 subjects enrolled but five did not complete interventions.</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">3. The area of secondary hyperalgesia was reduced after HBO exposure compared to air exposure and this effect carried over to the second session when HBO was given first. Thus, the effect persists for the 30 or so days between treatments.</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">4. These findings confirm the ability of HBO to cause neuroplasticity in experimental subjects.</span></span></span> |
<span style="font-size:large;"><span style="line-height:normal"> </span></span> | <span style="font-size:large;"><span style="line-height:normal"> </span></span> | ||
| − | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal">'''<span style="font-family:">Appraised by:</span>'''<span style="font-family:"> Mike Bennett; Sunday, 1 November 2020</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="font-family:">Email: m.bennett@unsw.edu.au</span></span></span> |
| − | <span style="font-size:large;"><span style="line-height:107%"><span style="font-family:" | + | <span style="font-size:large;"><span style="line-height:107%"><span style="font-family:">Kill or Update By: November 2022</span></span></span> |
| + | <p style="text-align: center;"> </p> <p style="text-align: center;">[[File:Sumhorsa.gif|center|Sumhorsa.gif]]</p> <p style="text-align: center;"> </p> <p style="text-align: center;"><span style="font-size:xx-large;">'''[[Burns|BACK]]'''</span></p> | ||
Revision as of 01:27, 1 November 2020
A single session of hyperbaric oxygen produces a protective effect against hyperalgesia that persisted for at least a month.
Clinical Bottom Line:
1. Hyperbaric oxygen following an experimental burn injury produced a reduced area of secondary hyperalgesia.
2. This effect persisted for at least one month. No changes were seen after air breathing control subjects.
Citation/s:1.Wahl AM, Bidstrup D, Smidt-Nielsen IG, Werner MU, Hyldegaard O, Rotbøll-Nielsen P. A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial. Journal of pain research. 2019;12:2337.
Lead author's name and email:Anna Wahl Annamygd@gmail.com
Three-part Clinical Question: For volunteers undergoing an experimental burn injury, does hyperbaric oxygen exposure compared to air breathing result in protection from subsequent hyperalgesia?
Search Terms: Thermal burn, nociception, hyperalgesia
The Study:Single-blinded concealed randomised controlled trial with intention-to-treat.
The Study Patients: Healthy volunteers having an experimenat first degree burn injury applied to the lower limb. Same injury as Rasmussen 2015. Trial was crossed over after a minimum of 28 days.
Control group (N = 22; 19 analysed): Air breathing at 1 ATA
Experimental group (N = 20; 19 analysed): One session of breathing 100% oxygen at 2.4 ATA for 90 minutes
Outcome |
Air breathing control |
Hyperbaric oxygen |
Difference |
P-value* | ||
Mean |
SD |
Mean |
SD |
13.2 |
0.02 | |
|
Secondary hyperalgesic area after injury (cm-sq) |
32.0 |
11.9 |
18.8 |
8.3 | ||
*Taken from paper – no 95% CI calculatable,
Comments:
1. Crossover design with examiner blinding to allocation.
2. 26 subjects enrolled but five did not complete interventions.
3. The area of secondary hyperalgesia was reduced after HBO exposure compared to air exposure and this effect carried over to the second session when HBO was given first. Thus, the effect persists for the 30 or so days between treatments.
4. These findings confirm the ability of HBO to cause neuroplasticity in experimental subjects.
Appraised by: Mike Bennett; Sunday, 1 November 2020
Email: m.bennett@unsw.edu.au
Kill or Update By: November 2022
