Difference between revisions of "Branco"

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==<span style="font-size: 16pt;">Improved subjective recovery with hyperbaric oxygen but no influence on markers of cellular damage or hormone levels</span>==
 
  
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=='''Clinical bottom line:'''==
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== <span style="font-size: 16pt;">Improved subjective recovery with hyperbaric oxygen but no influence on markers of cellular damage or hormone levels</span> ==
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{|
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| '''<span style'''"font-size: 11pt;">1.Hyperbaric oxygen was not associated with any objective differences in serum hormones or markers of cellular damage.</span>'''<br><br>**<span style'''"font-size: 11pt;"> 2. There were improvements in the subjective reporting of the degree of recovery following hyperbaric oxygen exposures. </span>'''  
+
== '''Clinical bottom line:''' ==
 +
 
 +
{|
 
|-
 
|-
 +
| '''<span>1.Hyperbaric oxygen was not associated with any objective differences in serum hormones or markers of cellular damage.</span>'''<br/> <br/> '''<span>2. There were improvements in the subjective reporting of the degree of recovery following hyperbaric oxygen exposures.</span>'''
 
|}
 
|}
  
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**<span style="font-size: 11pt;">Citation/s:</span>'''
+
'''<span style="font-size: 11pt;">Citation/s:&nbsp;</span>'''<span style="font-size: 11pt;">1. Branco BU, Fukuda DH, Andreato LV, da Silva Santos JF, Esteves JV, Franchini E. The effects of hyperbaric oxygen therapy on post-training recovery in jiu-jitsu athletes PloS one 2016;11(3:e0150517</span>
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<span style="font-size: 11pt;"> 1. Branco BU, Fukuda DH, Andreato LV, da Silva Santos JF, Esteves JV, Franchini E. The effects of hyperbaric oxygen therapy on post-training recovery in jiu-jitsu athletes PloS one 2016;11(3:e0150517 </span>
+
 
 +
<span style="font-size: 11pt;">'''Lead author's name and email:''' BH Branco </span> <span style="font-size: 120%;">brauliomagnani@live</span>
 +
 
 +
'''<span style="font-size: 11pt;">Three-part Clinical Question:</span>''''''<span style="font-size: 11pt;"></span>'''<span style="font-size: 11pt;">For Jui-Jitsu athletes, does the administration of hyperbaric oxygen following training sessions compared to rest, result in any effect on hormone concentrations or biochemical markers of cellular damage?</span>
 +
 
 +
'''<span style="font-size: 11pt;">Search Terms:</span>''''''<span style="font-size: 11pt;"></span>'''<span style="font-size: 11pt;">Exercise, recovery, martial arts</span>
 +
 
 +
<span style="font-size: 11pt;">'''The Study:''' Non-blinded randomised controlled trial with intention-to-treat.</span>
  
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<span style="font-size: 11pt;"> '''Lead author's name and email:''' BH Branco </span> <span style="font-size: 120%;">brauliomagnani@live.com</span>
+
<span style="font-size: 11pt;">'''The Study Patients:''' Adult male Jui-Jitsu athletes in regular training three times each week and without a current injury</span>
  
−
**<span style="font-size: 11pt;">Three-part Clinical Question:</span>'''<span style="font-size: 11pt;"> For Jui-Jitsu athletes, does the administration of hyperbaric oxygen following training sessions compared to rest, result in any effect on hormone concentrations or biochemical markers of cellular damage? </span>
+
'''<span style="font-size: 11pt;">Control group</span>''''''<span style="font-size: 11pt;">'''(</span>'''<span style="font-size: 11pt;">N = 11; 11 analysed): Passive recovery for 2 hours after two separate training sessions.</span>
−
**<span style="font-size: 11pt;">Search Terms:</span>'''<span style="font-size: 11pt;"> Exercise, recovery, martial arts</span>
 
−
**<span style="font-size: 11pt;">The Study: </span>'''<span style="font-size: 11pt;">Non-blinded randomised controlled trial with intention-to-treat.</span>
 
  
−
<span style="font-size: 11pt;"> '''The Study Patients:''' Adult male Jui-Jitsu athletes in regular training three times each week and without a current injury </span>
+
<span style="font-size: 11pt;">'''Experimental group''' (N = 11; 11 analysed): Breathing 100% oxygen at 2.4 ATA for one hour and 40 minutes after two separate training sessions, followed by a further 1 hour and 40 minute recovery period.</span>
−
**<span style="font-size: 11pt;">Control group</span>'''<span style="font-size: 11pt;"> (N = 11; 11 analysed): Passive recovery for 2 hours after two separate training sessions.</span>
 
−
**<span style="font-size: 11pt;">Experimental group</span>'''<span style="font-size: 11pt;"> (N = 11; 11 analysed): Breathing 100% oxygen at 2.4 ATA for one hour and 40 minutes after two separate training sessions, followed by a further 1 hour and 40 minute recovery period.</span>
 
  
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**<span style="font-size: 11pt;">The Evidence:</span>'''
+
'''<span style="font-size: 11pt;">The Evidence:</span>'''
  
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{|  
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{| class="Table" style="border:solid windowtext 1.0pt"
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| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Measure (means)</span>'''</span></span> |||| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Control Group</span>'''</span></span> |||| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">HBOT Group</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Difference</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style="font-size: 10pt;">95% CI</span>'''</span></span>
 
 
|-
 
|-
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|^  || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Mean</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">SD</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Mean</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">SD</span>'''</span></span> ||^  ||^ 
+
| rowspan="2" style="width:160.55pt; border:solid windowtext 1.0pt" width="214" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Measure (means)'''</p>  
 +
| colspan="2" style="width:83.55pt; border:solid windowtext 1.0pt" width="111" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Control Group'''</p>  
 +
| colspan="2" style="width:72.3pt; border:solid windowtext 1.0pt" width="96" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''HBOT Group'''</p>  
 +
| rowspan="2" style="width:50.15pt; border:solid windowtext 1.0pt" width="67" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Difference'''</p>
 +
| rowspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''95% CI'''</p>  
 
|-
 
|-
−
| '''<span style'''"font-size: 10pt;">Serum Creatine Kinase (units/L) at 2 hrs</span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">511</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">163</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">502</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">322</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">9</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-size: 10pt; text-align: center;">-218 to 236</span></span>  
+
| style="width:48.1pt; border:solid windowtext 1.0pt" width="64" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Mean'''</p>  
 +
| style="width:33.95pt; border:solid windowtext 1.0pt" width="45" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''SD'''</p>  
 +
| style="width:45.7pt; border:solid windowtext 1.0pt" width="61" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Mean'''</p>  
 +
| style="width:25.1pt; border:solid windowtext 1.0pt" width="33" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''SD'''</p>  
 
|-
 
|-
−
| '''<span style'''"font-size: 10pt;">Serum Creatine Kinase (units/L) at 24 hrs</span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">562</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">335</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">489</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">281</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">73</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-size: 10pt; text-align: center;">-202 to 348</span></span>  
+
| style="width:160.55pt; border:solid windowtext 1.0pt" width="214" |
 +
'''Serum Creatine Kinase (units/L) at 2 hrs'''
 +
 
 +
| style="width:48.1pt; border:solid windowtext 1.0pt" width="64" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">511</p>  
 +
| style="width:33.95pt; border:solid windowtext 1.0pt" width="45" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">163</p>  
 +
| style="width:45.7pt; border:solid windowtext 1.0pt" width="61" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">502</p>  
 +
| style="width:25.1pt; border:solid windowtext 1.0pt" width="33" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">322</p>  
 +
| style="width:50.15pt; border:solid windowtext 1.0pt" width="67" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">9</p>  
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">-218 to 236</p>  
 
|-
 
|-
−
| '''<span style'''"font-size: 10pt;">Serum cortisol (ng/ml) at 2 hours</span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">8.1</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">1.8</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">6.5</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">15.6</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">1.60</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-size: 10pt; text-align: center;">-8.3 to 11.5</span></span>  
+
| style="width:160.55pt; border:solid windowtext 1.0pt" width="214" |
 +
'''Serum Creatine Kinase (units/L) at 24 hrs'''
 +
 
 +
| style="width:48.1pt; border:solid windowtext 1.0pt" width="64" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">562</p>  
 +
| style="width:33.95pt; border:solid windowtext 1.0pt" width="45" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">335</p>  
 +
| style="width:45.7pt; border:solid windowtext 1.0pt" width="61" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">489</p>  
 +
| style="width:25.1pt; border:solid windowtext 1.0pt" width="33" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">281</p>  
 +
| style="width:50.15pt; border:solid windowtext 1.0pt" width="67" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">73</p>  
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">-202 to 348</p>  
 
|-
 
|-
 +
| style="width:160.55pt; border:solid windowtext 1.0pt" width="214" |
 +
'''Serum cortisol (ng/ml) at 2 hours'''
 +
 +
| style="width:48.1pt; border:solid windowtext 1.0pt" width="64" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">8.1</p>
 +
| style="width:33.95pt; border:solid windowtext 1.0pt" width="45" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">1.8</p>
 +
| style="width:45.7pt; border:solid windowtext 1.0pt" width="61" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">6.5</p>
 +
| style="width:25.1pt; border:solid windowtext 1.0pt" width="33" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">15.6</p>
 +
| style="width:50.15pt; border:solid windowtext 1.0pt" width="67" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">1.60</p>
 +
| style="border:solid windowtext 1.0pt" | <p style="text-align: center; padding: 0.75pt;">-8.3 to 11.5</p>
 
|}
 
|}
−
 
+
​​​​​​​
−
{|  
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{| class="Table" style="border:solid windowtext 1.0pt"
−
| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Measure (medians)</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Time to outcome/s</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Control group </span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">HBOT group</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style="font-size: 10pt;">P-value</span>'''</span></span>
 
 
|-
 
|-
−
| '''<span style'''"font-size: 10pt;">Ratings of Perceived Recovery (0 - 10 (worst))</span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">2 hours</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">6 (5 - 7)</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">8 (6 - 9)</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-size: 10pt; text-align: center;">< 0.05</span></span>  
+
| style="width:174.7pt; border:solid windowtext 1.0pt" width="233" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Measure (medians)'''</p>
 +
| style="width:90.65pt; border:solid windowtext 1.0pt" width="121" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Time to outcome/s'''</p>  
 +
| style="width:69.35pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Control group'''</p>  
 +
| style="width:71.2pt; border:solid windowtext 1.0pt" width="95" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''HBOT group'''</p>  
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''P-value'''</p>  
 
|-
 
|-
−
| '''<span style'''"font-size: 10pt;">Ratings of Perceived Recovery (0 - 10 (worst)) </span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">24 hours</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">9 (8 - 6)</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">10 (9 - 10)</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-size: 10pt; text-align: center;"><0.05</span></span>  
+
| style="width:174.7pt; border:solid windowtext 1.0pt" width="233" |
 +
'''Ratings of Perceived Recovery (0 - 10 (worst))'''
 +
 
 +
| style="width:90.65pt; border:solid windowtext 1.0pt" width="121" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">2 hours</p>  
 +
| style="width:69.35pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">6 (5 - 7)</p>  
 +
| style="width:71.2pt; border:solid windowtext 1.0pt" width="95" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">8 (6 - 9)</p>  
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">< 0.05</p>  
 
|-
 
|-
 +
| style="width:174.7pt; border:solid windowtext 1.0pt" width="233" |
 +
'''Ratings of Perceived Recovery (0 - 10 (worst))'''
 +
 +
| style="width:90.65pt; border:solid windowtext 1.0pt" width="121" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">24 hours</p>
 +
| style="width:69.35pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">9 (8 - 6)</p>
 +
| style="width:71.2pt; border:solid windowtext 1.0pt" width="95" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">10 (9 - 10)</p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><0.05</p>
 
|}
 
|}
  
−
**<span style="font-size: 11pt;">Comments:</span>'''
+
'''Comments'''
  
−
<span style="font-size: 11pt;"> 1. Crossover study with no attempt to blind participants or experimenters.</span>
+
<span style="font-size: 11pt;">1. Crossover study with no attempt to blind participants or experimenters.Comments:</span>
  
−
<span style="font-size: 11pt;"> 2. Thorough statistical approach with ANOVA and post-hoc Bonferroni correction. The meaning if the difference between groups used to calculate sample size is not clear.</span>
+
<span style="font-size: 11pt;">2. Thorough statistical approach with ANOVA and post-hoc Bonferroni correction. The meaning if the difference between groups used to calculate sample size is not clear.</span>
  
−
<span style="font-size: 11pt;"> 3. Authors emphasise the biochemical results over the subjective outcomes.</span>
+
<span style="font-size: 11pt;">3. Authors emphasise the biochemical results over the subjective outcomes.</span>
  
−
<span style="font-size: 11pt;"> 4. The improvement in subjective recovery scores at 24 hours seems very modest and may be of little practical importance. </span>
+
<span style="font-size: 11pt;">4. The improvement in subjective recovery scores at 24 hours seems very modest and may be of little practical importance.</span>
  
−
<span style="font-size: 11pt;"> 5. Lack of blinding may have influenced the subjective outcome. </span>
+
<span style="font-size: 11pt;">5. Lack of blinding may have influenced the subjective outcome.</span>
  
−
**<span style="font-size: 11pt;">Appraised by</span>'''<span style="font-size: 11pt;">: Michael Bennett m.bennett@unsw.edu.au ; Monday, 9 April 2018</span>
+
'''​​​​​​​<span style="font-size: 11pt;">Appraised by</span>''''''<span style="font-size: 11pt;">''': '''; Monday, 9 April</span>'''<span style="font-size: 11pt;">Michael Bennett m.bennett@unsw.edu.au&nbsp;</span>'''<span style="font-size: 11pt;">&nbsp;</span>'''
−
**<span style="font-size: 11pt;">Kill or Update By:</span>'''<span style="font-size: 11pt;"> April 2021</span>
 
  
 +
'''<span style="font-size: 11pt;">Kill or Update By:</span>''''''<span style="font-size: 11pt;"></span>'''<span style="font-size: 11pt;">April 2025</span>
  
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[[File:Sumhorsa.gif|center|Sumhorsa.gif]] <span style="display: block; text-align: center;"></span><span style="display: block; text-align: center;"></span><span style="display: block; text-align: center;"><span style="font-size: 160%;">[[Sports|BACK]]</span></span><span style="display: block; text-align: center;"></span><span style="display: block; text-align: center;"></span>
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</span><span style="display: block; text-align: center;"><span style="font-size: 160%;">[[Sports | BACK]]</span></span><span style="display: block; text-align: center;">
 
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Latest revision as of 03:02, 11 April 2020

Improved subjective recovery with hyperbaric oxygen but no influence on markers of cellular damage or hormone levels

Clinical bottom line:

1.Hyperbaric oxygen was not associated with any objective differences in serum hormones or markers of cellular damage.

2. There were improvements in the subjective reporting of the degree of recovery following hyperbaric oxygen exposures.

Citation/s: 1. Branco BU, Fukuda DH, Andreato LV, da Silva Santos JF, Esteves JV, Franchini E. The effects of hyperbaric oxygen therapy on post-training recovery in jiu-jitsu athletes PloS one 2016;11(3:e0150517

Lead author's name and email: BH Branco brauliomagnani@live

'Three-part Clinical Question:'For Jui-Jitsu athletes, does the administration of hyperbaric oxygen following training sessions compared to rest, result in any effect on hormone concentrations or biochemical markers of cellular damage?

'Search Terms:'Exercise, recovery, martial arts

The Study: Non-blinded randomised controlled trial with intention-to-treat.

The Study Patients: Adult male Jui-Jitsu athletes in regular training three times each week and without a current injury

Control group'(N = 11; 11 analysed): Passive recovery for 2 hours after two separate training sessions.

Experimental group (N = 11; 11 analysed): Breathing 100% oxygen at 2.4 ATA for one hour and 40 minutes after two separate training sessions, followed by a further 1 hour and 40 minute recovery period.

The Evidence:

Measure (means)

Control Group

HBOT Group

Difference

95% CI

Mean

SD

Mean

SD

Serum Creatine Kinase (units/L) at 2 hrs

511

163

502

322

9

-218 to 236

Serum Creatine Kinase (units/L) at 24 hrs

562

335

489

281

73

-202 to 348

Serum cortisol (ng/ml) at 2 hours

8.1

1.8

6.5

15.6

1.60

-8.3 to 11.5

​​​​​​​

Measure (medians)

Time to outcome/s

Control group

HBOT group

P-value

Ratings of Perceived Recovery (0 - 10 (worst))

2 hours

6 (5 - 7)

8 (6 - 9)

< 0.05

Ratings of Perceived Recovery (0 - 10 (worst))

24 hours

9 (8 - 6)

10 (9 - 10)

<0.05

Comments

1. Crossover study with no attempt to blind participants or experimenters.Comments:

2. Thorough statistical approach with ANOVA and post-hoc Bonferroni correction. The meaning if the difference between groups used to calculate sample size is not clear.

3. Authors emphasise the biochemical results over the subjective outcomes.

4. The improvement in subjective recovery scores at 24 hours seems very modest and may be of little practical importance.

5. Lack of blinding may have influenced the subjective outcome.

'​​​​​​​Appraised by': ; Monday, 9 AprilMichael Bennett m.bennett@unsw.edu.au  

'Kill or Update By:'April 2025

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