Difference between revisions of "Woo"
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#<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Clinical significance unclear.</span></span> | #<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Clinical significance unclear.</span></span> | ||
#<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Post-exercise HBO exposure may reduce markers of inflammation and muscle damage, but results uncertain.</span></span> | #<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Post-exercise HBO exposure may reduce markers of inflammation and muscle damage, but results uncertain.</span></span> | ||
| − | #<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Also some modest reduction in oxidative stress possible.</span></span> | + | #<span lang="EN-US" style="font-size:14.0pt"><span style="line-height:107%">Also some modest reduction in oxidative stress possible.</span></span><span style="line-height:107%"> </span> |
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| − | <span style="line-height:107%">'''Lead author’s name and email: '''Jinhee Woo : jop9508@naver.com</span> | + | <span style="line-height:107%">'''Lead author’s name and email: '''Jinhee Woo : jop9508@naver.com</span> |
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#Authors also tested a group exercising in hypoxia (PiO2 = 0.1 ATA) and then recovered in HBO conditions. Not discussed here. | #Authors also tested a group exercising in hypoxia (PiO2 = 0.1 ATA) and then recovered in HBO conditions. Not discussed here. | ||
#All outcome data here is read from graphical display of results. The report is rather confusing. | #All outcome data here is read from graphical display of results. The report is rather confusing. | ||
| + | #Described as a pilot study, but definitive plans are vague. | ||
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| − | <span style="line-height:107%">'''Appraised by'''</span> | + | <span style="line-height:107%">'''Appraised by: '''</span><span style="line-height:107%">Bosco Tran [mailto:bosco.tran@student.unsw.edu.au bosco.tran@student.unsw.edu.au]</span> |
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| − | <span style="line-height:107%">Bosco Tran [mailto:bosco.tran@student.unsw.edu.au bosco.tran@student.unsw.edu.au]</span> | ||
| − | <span style="line-height:107%"> | + | <span style="line-height:107%">'''Kill or update by''': February 2025</span> |
Revision as of 22:55, 6 February 2022
A single hyperbaric oxygen exposure may reduce inflammatory and muscle damage markers following exercise in normal conditions.
Clinical bottom line:
- Clinical significance unclear.
- Post-exercise HBO exposure may reduce markers of inflammation and muscle damage, but results uncertain.
- Also some modest reduction in oxidative stress possible.
Citation: Woo J, Min JH, Lee YH, Roh HT. Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study. International Journal of Environmental Research and Public Health. 2020 October 17:7377.
Lead author’s name and email: Jinhee Woo : jop9508@naver.com
Three-part clinical question: For individuals exercising in either air or hypobaric hypoxic environments, does a later rest period breathing hyperbaric oxygen, compared to air, result in reduced serum inflammatory, oxidative and muscle damage markers?
Search terms: Exercise, oxidative stress, muscle damage
The study: Non-blinded randomised controlled trial with intention-to-treat.
The study patients: Healthy male volunteers with BMI under 30 kg/m2.
Control group: (N = 6; 6 analysed): Treadmill run for 60 minutes at 75-80% max heart rate breathing air at 1 (PiO2 = 0.2 ATA) followed by air breathing rest for 60 minutes.
Experimental group: (N = 6; 6 analysed): As above for exercise, but breathing 100% oxygen at 2.5 ATA for 60 minutes.
The evidence
Measure |
Air Group |
HBO Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Interleukin-6 (pg/ml at 60 mins) |
911 |
111 |
900 |
53 |
11 |
-9720 to 9742 |
|
Biological antioxidant potential (BAP) (micromole/L at 60 mins) |
2773 |
182 |
2545 |
227 |
228 |
-54217 to 54673 |
|
Creatine Kinase (u/L) |
255 |
59 |
227 |
64 |
28 |
-4844 to 4900 |
Note: Interleukin-6 used as marker of inflammation, BAP as a measure of oxidative stress, CK as an indicator of muscle damage
Comments:
- Clinical significance of the findings is not clear.
- Authors also tested a group exercising in hypoxia (PiO2 = 0.1 ATA) and then recovered in HBO conditions. Not discussed here.
- All outcome data here is read from graphical display of results. The report is rather confusing.
- Described as a pilot study, but definitive plans are vague.
Appraised by: Bosco Tran bosco.tran@student.unsw.edu.au
Kill or update by: February 2025
