Difference between revisions of "Chen"
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| − | <span style="font-size:x-large;">'''<span style="font-family: | + | <span style="font-size:x-large;">'''<span style="font-family:">Muscle pain and markers of muscle damage were improved after a course of hyperbaric oxygen therapy</span>'''</span> |
| − | <span style="font-size:large;">'''<span style="font-family: | + | <span style="font-size:large;">'''<span style="font-family:">Clinical Bottom Line:</span>'''</span> |
| − | <span style="font-size:medium;"><span style="font-family: | + | <span style="font-size:medium;"><span style="font-family:">1. HBOT reduced some markers of muscle injury</span></span> |
| − | <span style="font-size:medium;"><span style="font-family: | + | <span style="font-size:medium;"><span style="font-family:">2. HBOT resulted in lower pain scores after ten treatments for muscle strain injuries in athletes.</span></span> |
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| − | <span style="font-size:medium;">'''<span style="font-family: | + | <span style="font-size:medium;">'''<span style="font-family:">Citation/s:</span>'''<span style="font-family:">1.Chen CY, Chou WY, Ko JY, Lee MS, Wu RW. Early recovery of exercise-related muscular injury by HBOT. BioMed Research International. 6289380; 2019</span></span> |
| − | <span style="font-size:medium;">'''<span style="font-family: | + | <span style="font-size:medium;">'''<span style="font-family:">Lead author's name and fax:</span>'''<span style="font-family:">Re-Wen Wu: ray4595@gmail.com</span></span> |
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| − | <span style="font-size:medium;">'''<span style="font-family: | + | <span style="font-size:medium;">'''<span style="font-family:">Three-part Clinical Question:</span>'''<span style="font-family:">In elite athletes, does exposure to hyperbaric oxygen compared to standard approaches, promote recovery from muscular injury?</span></span> |
| − | <span style="font-size:medium;"><span style="font-family: | + | <span style="font-size:medium;"><span style="font-family:">'''Search Terms:''' Athletes; recovery; pain</span></span> |
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| − | <span style="font-size:medium;">'''<span style="font-family: | + | <span style="font-size:medium;">'''<span style="font-family:">The Study:</span>'''</span> |
| − | <span style="font-size:medium;"><span style="font-family: | + | <span style="font-size:medium;"><span style="font-family:">Double-blinded concealed randomised controlled trial with intention-to-treat.</span></span> |
| − | <span style="font-size:medium;">'''<span style="font-family: | + | <span style="font-size:medium;">'''<span style="font-family:">The Study Patients:</span>'''<span style="font-family:"> Adult baseball players with minor muscle strains lasting more than two weeks that did not interrupt their athletic schedule.</span></span> |
| − | <span style="font-size:medium;"><span style="font-family: | + | <span style="font-size:medium;"><span style="font-family:">Control group (N = 23; 21 analysed): Sham treatment breathing air at 1.3ATA on the same time schedule as the experimental group.</span></span> |
| − | <span style="font-size:medium;"><span style="font-family: | + | <span style="font-size:medium;"><span style="font-family:">Experimental group (N = 23; 20 analysed): 100% oxygen breathing at 2.5 ATA for 60m minutes daily for 10 days.</span></span> |
| − | '''<span style="font-family: | + | '''<span style="font-family:">The Evidence:</span>''' |
{| class="Table" style="border:undefined" | {| class="Table" style="border:undefined" | ||
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| − | | rowspan="2" style="width:153.3pt" width="207" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | rowspan="2" style="width:153.3pt" width="207" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Measure</span></span>'''</span></p> |
| − | | colspan="2" style="width:90.65pt" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | colspan="2" style="width:90.65pt" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Sham Group</span></span>'''</span></p> |
| − | | colspan="2" style="width:83.55pt" width="114" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | colspan="2" style="width:83.55pt" width="114" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">HBOT Group</span></span>'''</span></p> |
| − | | rowspan="2" style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | rowspan="2" style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Difference</span></span>'''</span></p> |
| − | | rowspan="2" style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | rowspan="2" style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">95% CI</span></span>'''</span></p> |
|- | |- | ||
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Mean</span></span>'''</span></p> |
| − | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">SD</span></span>'''</span></p> |
| − | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Mean</span></span>'''</span></p> |
| − | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">SD</span></span>'''</span></p> |
|- | |- | ||
| style="width:153.3pt" width="207" | | | style="width:153.3pt" width="207" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Serum creatine phosphokinase (U/L) at end of 10 treatments</span></span>'''</span> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">327.1</span></span></span></p> |
| − | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">181.1</span></span></span></p> |
| − | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">158.5</span></span></span></p> |
| − | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">78.0</span></span></span></p> |
| − | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">168.6</span></span></span></p> |
| − | | style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-158.8 to 192.8</span></span></span></p> |
|- | |- | ||
| style="width:153.3pt" width="207" | | | style="width:153.3pt" width="207" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Myoglobin (ng/mL) at end of 10 treatments</span></span>'''</span> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">43.3</span></span></span></p> |
| − | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">19.4</span></span></span></p> |
| − | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">19.4</span></span></span></p> |
| − | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">10.2</span></span></span></p> |
| − | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">25.3</span></span></span></p> |
| − | | style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-92.6 to 143.2</span></span></span></p> |
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| style="width:153.3pt" width="207" | | | style="width:153.3pt" width="207" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">Pain on average in the last week (0 to 10 scale) at end of 10 treatments</span></span>'''</span> |
| − | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:48.1pt" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">3.5</span></span></span></p> |
| − | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:41.05pt" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.6</span></span></span></p> |
| − | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:26.85pt" width="38" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.8</span></span></span></p> |
| − | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">1.6</span></span></span></p> |
| − | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:55.2pt" width="76" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">8.29</span></span></span></p> |
| − | | style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | | style="width:69.35pt" width="95" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-49.7 to 66.3</span></span></span></p> |
|} | |} | ||
| − | | + | |
| − | | + | '''<span style="font-size:11.0pt"><span style="line-height:107%"><span style="font-family:">Comments:</span></span></span>''' <span style="font-family: Arial, sans-serif; font-size: 11pt;">1. Generally high-quality study with good randomisation and blinding</span> |
| − | '''<span style="font-size:11.0pt"><span style="line-height:107%"><span style="font-family: | ||
| − | <span style="font-family: Arial, sans-serif; font-size: 11pt;">1. Generally high-quality study with good randomisation and blinding</span> | ||
<span style="font-family: Arial, sans-serif; font-size: 11pt;">2. Study was powered at 80% to show a difference of 12.9 on the 'Brief Pain Inventory'. This appears to be a combination of seven pain dimensions for pain intensity and effect on life, but that result is not given in the paper - only the individual element scores.</span> | <span style="font-family: Arial, sans-serif; font-size: 11pt;">2. Study was powered at 80% to show a difference of 12.9 on the 'Brief Pain Inventory'. This appears to be a combination of seven pain dimensions for pain intensity and effect on life, but that result is not given in the paper - only the individual element scores.</span> | ||
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<span style="font-family: Arial, sans-serif; font-size: 11pt;">4. These results are at odds with previously published data- this may reflect a different demographic and the grade and chronicity of injury</span> | <span style="font-family: Arial, sans-serif; font-size: 11pt;">4. These results are at odds with previously published data- this may reflect a different demographic and the grade and chronicity of injury</span> | ||
| − | '''<span style="font-size:11.0pt"><span style="line-height:107%"><span style="font-family: | + | '''<span style="font-size:11.0pt"><span style="line-height:107%"><span style="font-family:">Appraised by:</span></span></span>'''<span style="font-size: 11pt;"><span style="line-height:107%"><span style="font-family:">Mike Bennett; Sunday, 26 April 2020</span></span></span> |
<span style="font-family: Arial, sans-serif; font-size: 11pt;">'''Email: '''m.bennett@unsw.edu.au</span> | <span style="font-family: Arial, sans-serif; font-size: 11pt;">'''Email: '''m.bennett@unsw.edu.au</span> | ||
<span style="font-family: Arial, sans-serif; font-size: 11pt;">Kill or Update By: April 2023</span> | <span style="font-family: Arial, sans-serif; font-size: 11pt;">Kill or Update By: April 2023</span> | ||
| − | + | <p style="text-align: center;">[[File:Sumhorsa.gif|center|Sumhorsa.gif]]</p> <p style="text-align: center;">[[Sports|<span style="font-size:x-large;">BACK</span>]]</p> | |
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Revision as of 21:47, 3 May 2020
Muscle pain and markers of muscle damage were improved after a course of hyperbaric oxygen therapy
Clinical Bottom Line:
1. HBOT reduced some markers of muscle injury
2. HBOT resulted in lower pain scores after ten treatments for muscle strain injuries in athletes.
Citation/s:1.Chen CY, Chou WY, Ko JY, Lee MS, Wu RW. Early recovery of exercise-related muscular injury by HBOT. BioMed Research International. 6289380; 2019
Lead author's name and fax:Re-Wen Wu: ray4595@gmail.com
Three-part Clinical Question:In elite athletes, does exposure to hyperbaric oxygen compared to standard approaches, promote recovery from muscular injury?
Search Terms: Athletes; recovery; pain
The Study:
Double-blinded concealed randomised controlled trial with intention-to-treat.
The Study Patients: Adult baseball players with minor muscle strains lasting more than two weeks that did not interrupt their athletic schedule.
Control group (N = 23; 21 analysed): Sham treatment breathing air at 1.3ATA on the same time schedule as the experimental group.
Experimental group (N = 23; 20 analysed): 100% oxygen breathing at 2.5 ATA for 60m minutes daily for 10 days.
The Evidence:
Measure |
Sham Group |
HBOT Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Serum creatine phosphokinase (U/L) at end of 10 treatments |
327.1 |
181.1 |
158.5 |
78.0 |
168.6 |
-158.8 to 192.8 |
|
Myoglobin (ng/mL) at end of 10 treatments |
43.3 |
19.4 |
19.4 |
10.2 |
25.3 |
-92.6 to 143.2 |
|
Pain on average in the last week (0 to 10 scale) at end of 10 treatments |
3.5 |
1.6 |
1.8 |
1.6 |
8.29 |
-49.7 to 66.3 |
Comments: 1. Generally high-quality study with good randomisation and blinding
2. Study was powered at 80% to show a difference of 12.9 on the 'Brief Pain Inventory'. This appears to be a combination of seven pain dimensions for pain intensity and effect on life, but that result is not given in the paper - only the individual element scores.
3. Elements of the BPI were all less than 5 and we have presumed these are out of a maximum score of 10.
4. These results are at odds with previously published data- this may reflect a different demographic and the grade and chronicity of injury
Appraised by:Mike Bennett; Sunday, 26 April 2020
Email: m.bennett@unsw.edu.au
Kill or Update By: April 2023
