Difference between revisions of "Van Ophoven"

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<span style="color: #000000; font-family: Arial,Helvetica,sans-serif; font-size: 130%;">'''Hyperbaric oxygen therapy reduced pain associated with interstitial cystitis''' </span>
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<span style="color: #000000; font-family: Arial,Helvetica,sans-serif; font-size: 130%;">'''Hyperbaric oxygen therapy reduced pain associated with interstitial cystitis'''</span>
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| <span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Clinical bottom line:'''</span><br><span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''1. Mean pain score reduced following HBOT2. Trend toward benefit from HBOT for urgency, frequency, bladder volume and subjective response, but no statistically significant differences'''</span>
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| <span>'''Clinical bottom line:'''</span><br/> <span>'''1. Mean pain score reduced following HBOT2. Trend toward benefit from HBOT for urgency, frequency, bladder volume and subjective response, but no statistically significant differences'''</span>
 
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Citation/s:'''1. van Ophoven A, Rossbach G, Pajonk F, Hertle L. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis a randomised, sham controlled, double blind trial. Journal of Urology 2006; 176:1442-1446.</span>
 
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Lead author's name and fax:''' [[mailto:avo@uni-muenster.de | avo@uni-muenster.de]]</span>
 
  
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Three-part Clinical Question:''' For patients with interstitial cystitis, does the application of hyperbaric oxygen result in any improvement in symptoms?</span>
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Citation/s:'''1. van Ophoven A, Rossbach G, Pajonk F, Hertle L. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis a randomised, sham controlled, double blind trial. Journal of Urology 2006; 176:1442-1446.</span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Lead author's name and fax:''' [[mailto:avo@uni-muenster.de| avo@uni-muenster.de]]</span>
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Search Terms:''' Cysitis, interstitial, pelvic pain</span>
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Three-part Clinical Question:''' For patients with interstitial cystitis, does the application of hyperbaric oxygen result in any improvement in symptoms?</span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Search Terms:''' Cysitis, interstitial, pelvic pain</span>
  
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study:'''Double-blinded randomised controlled trial with intention-to-treat.</span>
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study:'''Double-blinded randomised controlled trial with intention-to-treat.</span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study Patients:''' Adult women with a diagnosis of interstitial cystitis.</span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Control group''' (N = 7; 7 analysed): Baseline therapy for each individual was continued plus air breathing at 1.3 to 1.4 ATA for 90 minutes daily to 30 sessions over 5 weeks.</span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Experimental group''' (N = 14; 14 analysed): As above but 100% oxygen breathing at 2.4 ATA.</span>
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Study Patients:''' Adult women with a diagnosis of interstitial cystitis.</span>
 
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Control group''' (N = 7; 7 analysed): Baseline therapy for each individual was continued plus air breathing at 1.3 to 1.4 ATA for 90 minutes daily to 30 sessions over 5 weeks.</span>
 
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<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Experimental group''' (N = 14; 14 analysed): As above but 100% oxygen breathing at 2.4 ATA.</span>
 
  
 
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Evidence:'''</span>
 
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''The Evidence:'''</span>
  
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| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Outcome</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Time to Outcome</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Sham rate</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">HBO rate</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Relative risk reduction</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Absolute risk reduction</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style="font-family: Arial,Helvetica,sans-serif; font-size: 110%;">NNT</span>'''</span></span>
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{| class="Table" style="border: 1pt solid windowtext; width: 733px;"
 
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| <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Symptomatic responders''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">3 months </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">0 </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">0.21 </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">INF </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">0.21 </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">5 </span></span>  
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| style="width:71.25pt; border:solid windowtext 1.0pt" width="98" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Outcome</span></span>'''</span></p>  
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| style="width:52.1pt; border:solid windowtext 1.0pt" width="71" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Time to Outcome</span></span>'''</span></p>
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| style="width: 68px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Sham rate</span></span>'''</span></p>
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| style="width: 64px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">HBO rate</span></span>'''</span></p>
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| style="width: 120px; border: 1pt solid windowtext;" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Relative risk reduction</span></span>'''</span></p>
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| style="width: 111px; border: 1pt solid windowtext;" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Absolute risk reduction</span></span>'''</span></p>
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| style="width: 152px; border: 1pt solid windowtext;" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:13.0pt"><span style="font-family:" arial",sans-serif"="">NNT</span></span>'''</span></p>  
 
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|^  |||||| <span style'''"display: block; text-align: right;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: right;">95% Confidence Intervals:</span></span> ||  || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">-0.001 to 0.43</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">NNT ''' 2 to INF</span></span><span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">NNH ''' 1,194 to INF</span></span>  
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<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Symptomatic responders</span></span>'''</span>
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| style="width:52.1pt; border:solid windowtext 1.0pt" width="71" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">3 months</span></span></span></p>
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| style="width: 68px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">0</span></span></span></p>
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| style="width: 64px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">0.21</span></span></span></p>
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| style="width: 120px; border: 1pt solid windowtext;" width="94" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">INF</span></span></span></p>
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| style="width: 111px; border: 1pt solid windowtext;" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">0.21</span></span></span></p>
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| style="width: 152px; border: 1pt solid windowtext;" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">5</span></span></span></p>  
 
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| style="width:71.25pt; border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" width="98" | &nbsp;
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| style="width:52.1pt; border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" width="71" | &nbsp;
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| style="width: 68px; border: 1pt solid windowtext; padding: 0.75pt;" width="57" | &nbsp;
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| style="width: 64px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">95% CIs:</span></span></span></p>
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| style="width: 120px; border: 1pt solid windowtext; padding: 0.75pt;" width="94" | &nbsp;
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| style="width: 111px; border: 1pt solid windowtext;" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">-0.001 to 0.43</span></span></span></p>
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| style="width: 152px; border: 1pt solid windowtext;" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">NNT 2 to INF;</span></span></span></p> <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">NNH'''1,194 to INF</span></span></span></p>
 
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| <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Measure''' </span></span> |||| <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Sham Group''' </span></span> |||| <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''HBO Group''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Difference''' </span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''95% CI''' </span></span>
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{| class="Table" style="border: 1pt solid windowtext; width: 734px;"
 
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|^  || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Mean'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''SD'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''Mean'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">'''SD'''</span></span> ||^  ||^ 
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| style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Measure</span></span>'''</span></p>
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| colspan="2" style="border: 1pt solid windowtext; width: 116px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Sham Group</span></span>'''</span></p>  
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| colspan="2" style="border: 1pt solid windowtext; width: 91px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">HBO Group</span></span>'''</span></p>  
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| style="border: 1pt solid windowtext; width: 84px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Difference</span></span>'''</span></p>  
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| style="border: 1pt solid windowtext; width: 151px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">95% CI</span></span>'''</span></p>  
 
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| <span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Interstitial cystitis index at 3 months</span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">26.7</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">5.8</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">19.9</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">7.9</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">6.8</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">-0.28 to 13.88</span></span>  
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| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | &nbsp;
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| style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Mean</span></span>'''</span></p>
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| style="border: 1pt solid windowtext; width: 61px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">SD</span></span>'''</span></p>
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| style="border: 1pt solid windowtext; width: 19px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Mean</span></span>'''</span></p>
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| style="border: 1pt solid windowtext; width: 66px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">SD</span></span>'''</span></p>
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| style="border: 1pt solid windowtext; width: 84px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt">&nbsp;</p>  
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| style="border: 1pt solid windowtext; width: 151px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt">&nbsp;</p>  
 
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| <span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Pain score (VAS) 3 months (0-100)</span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">55.7</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">27.8</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">31.2</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">19.8</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">24.5</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">2.57 to 46.43</span></span>  
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<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Interstitial cystitis index at 3 months</span></span>'''</span>
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| style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">26.7</span></span></span></p>
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| style="border: 1pt solid windowtext; width: 61px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">5.8</span></span></span></p>
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| style="border: 1pt solid windowtext; width: 19px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">19.9</span></span></span></p>
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| style="border: 1pt solid windowtext; width: 66px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">7.9</span></span></span></p>
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| style="border: 1pt solid windowtext; width: 84px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">6.8</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 151px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:13.0pt"><span style="font-family:" arial",sans-serif"="">-0.28 to 13.88</span></span></span></p>  
 
|-
 
|-
−
| <span style'''"font-family: Arial,Helvetica,sans-serif; font-size: 110%;">Bladder volume 3 months (mls)</span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">118</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">36</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">147</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">49</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">29</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-family: arial,helvetica,sans-serif; font-size: 110%; text-align: center;">-14.60 to 72.60</span></span>  
+
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Pain score (VAS) 3 months (0-100)</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">55.7</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 61px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">27.8</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 19px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">31.2</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 66px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">19.8</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 84px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">24.5</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 151px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:13.0pt"><span style="font-family:" arial",sans-serif"="">2.57 to 46.43</span></span></span></p>  
 
|-
 
|-
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Bladder volume 3 months (mls)</span></span>'''</span>
 +
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">118</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 61px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">36</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 19px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">147</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 66px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">49</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 84px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">29</span></span></span></p>
 +
| style="border: 1pt solid windowtext; width: 151px;" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:13.0pt"><span style="font-family:" arial",sans-serif"="">-14.60 to 72.60</span></span></span></p>
 
|}
 
|}
−
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Comments:'''</span>
 
−
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1. The difference in the proportion of symptomatic responders on a subjective scale (3 HBO versus 0 sham) is reported in the paper as statistically significant (P<0.05), but our calculations do not support this finding (P=0.55 by Fisher's exact test, double one-sided P method). {''Authors agree with the published figure is incorrect''.}</span>
 
−
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">2. Underpowered study with no sample size calculation. </span>
 
  
−
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Appraised by:''' Sean Hopson and Mike Bennett, Sydney; Friday, 10 November 2006Email: [[mailto:m.bennett@unsw.edu.au | m.bennett@unsw.edu.au]]</span>
+
<br/> &nbsp;
 +
 
 +
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Comments:'''</span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">1. The difference in the proportion of symptomatic responders on a subjective scale (3 HBO versus 0 sham) is reported in the paper as statistically significant (P<0.05), but our calculations do not support this finding (P=0.55 by Fisher's exact test, double one-sided P method). {''Authors agree the published figure is incorrect''.}</span>
 +
 
 +
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">2. Underpowered study with no sample size calculation.</span>
 +
 
 +
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Appraised by:''' Sean Hopson and Mike Bennett, Sydney; Friday, 10 November 2006Email: [[mailto:m.bennett@unsw.edu.au| m.bennett@unsw.edu.au]]</span>
 +
 
 
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Kill or Update By:''' March 2007</span>
 
<span style="font-family: Arial,Helvetica,sans-serif; font-size: 120%;">'''Kill or Update By:''' March 2007</span>
  
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[[File:Http://www.hboevidence.com/ themes/copy-of-sumi-painting/sumhorsa.gif|center|external]]
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<span style="color: #7c00ff; display: block; font-family: arial,helvetica,sans-serif; font-size: 26px; text-align: center;">[[Miscellaneous|BACK]]</span>
  
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<span style="color: #7c00ff; display: block; font-family: arial,helvetica,sans-serif; font-size: 26px; text-align: center;">[[Miscellaneous  |  BACK]]</span>
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Latest revision as of 03:38, 25 July 2019

Hyperbaric oxygen therapy reduced pain associated with interstitial cystitis

Clinical bottom line:
1. Mean pain score reduced following HBOT2. Trend toward benefit from HBOT for urgency, frequency, bladder volume and subjective response, but no statistically significant differences

Citation/s:1. van Ophoven A, Rossbach G, Pajonk F, Hertle L. Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis a randomised, sham controlled, double blind trial. Journal of Urology 2006; 176:1442-1446. Lead author's name and fax: [avo@uni-muenster.de]

Three-part Clinical Question: For patients with interstitial cystitis, does the application of hyperbaric oxygen result in any improvement in symptoms? Search Terms: Cysitis, interstitial, pelvic pain

The Study:Double-blinded randomised controlled trial with intention-to-treat. The Study Patients: Adult women with a diagnosis of interstitial cystitis. Control group (N = 7; 7 analysed): Baseline therapy for each individual was continued plus air breathing at 1.3 to 1.4 ATA for 90 minutes daily to 30 sessions over 5 weeks. Experimental group (N = 14; 14 analysed): As above but 100% oxygen breathing at 2.4 ATA.

The Evidence:

 

Outcome

Time to Outcome

Sham rate

HBO rate

Relative risk reduction

Absolute risk reduction

NNT

Symptomatic responders

3 months

0

0.21

INF

0.21

5

     

95% CIs:

  

-0.001 to 0.43

NNT 2 to INF;

NNH1,194 to INF

 

Measure

Sham Group

HBO Group

Difference

95% CI

 

Mean

SD

Mean

SD

 

 

Interstitial cystitis index at 3 months

26.7

5.8

19.9

7.9

6.8

-0.28 to 13.88

Pain score (VAS) 3 months (0-100)

55.7

27.8

31.2

19.8

24.5

2.57 to 46.43

Bladder volume 3 months (mls)

118

36

147

49

29

-14.60 to 72.60


 

Comments: 1. The difference in the proportion of symptomatic responders on a subjective scale (3 HBO versus 0 sham) is reported in the paper as statistically significant (P<0.05), but our calculations do not support this finding (P=0.55 by Fisher's exact test, double one-sided P method). {Authors agree the published figure is incorrect.}

2. Underpowered study with no sample size calculation.

Appraised by: Sean Hopson and Mike Bennett, Sydney; Friday, 10 November 2006Email: [m.bennett@unsw.edu.au]

Kill or Update By: March 2007

external

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