Difference between revisions of "Nogueira-Filho"
(Imported from Wikispaces) |
|||
| Line 1: | Line 1: | ||
| − | =Some evidence that adjunctive HBOT improves outcome in severe chronic periodontitis at three months.= | + | |
| − | {| | + | = Some evidence that adjunctive HBOT improves outcome in severe chronic periodontitis at three months. = |
| − | + | ||
| + | {| | ||
|- | |- | ||
| + | | <span style="font-size:medium;">1. No difference at three months in the plaque index or proportion of sites bleeding on probing.<br/> <br/> 2. Significantly improved mean probing depth and clinical attachment level at three months</span> | ||
|} | |} | ||
| + | |||
<span style="font-size: 110%;">'''Citation:''' Nogueira-Filho GR, Rosa BT, David-Neto JR. 3. Effects of hyperbaric oxygen therapy on the treatment of severe cases of periodontitis. UHM 2010;37(2):107-113.</span> | <span style="font-size: 110%;">'''Citation:''' Nogueira-Filho GR, Rosa BT, David-Neto JR. 3. Effects of hyperbaric oxygen therapy on the treatment of severe cases of periodontitis. UHM 2010;37(2):107-113.</span> | ||
| − | <span style="font-size: 110%;">'''Lead author's name and fax:''' Getulio Nogueira-Filho nogueira@cc.umanitoba.ca</span> | + | <span style="font-size: 110%;">'''Lead author's name and fax:''' Getulio Nogueira-Filho nogueira@cc.umanitoba.ca</span> <span style="font-size: 110%;">'''Three-part Clinical Question:''' For patients with severe periodontitis, does the adjunctive use of hyperbaric oxygen compared to standard therapy with scaling and root planing only, result in any improvement in outcome?</span> |
| − | <span style="font-size: 110%;">'''Three-part Clinical Question:''' For patients with severe periodontitis, does the adjunctive use of hyperbaric oxygen compared to standard therapy with scaling and root planing only, result in any improvement in outcome?</span> | ||
<span style="font-size: 110%;">'''Search Terms:''' periodonitis, chronic severe; hyperbaric oxygen</span> | <span style="font-size: 110%;">'''Search Terms:''' periodonitis, chronic severe; hyperbaric oxygen</span> | ||
| Line 13: | Line 15: | ||
<span style="font-size: 110%;">'''The Study:''' Single-blinded concealed randomised controlled trial with intention-to-treat.</span> | <span style="font-size: 110%;">'''The Study:''' Single-blinded concealed randomised controlled trial with intention-to-treat.</span> | ||
| − | <span style="font-size: 110%;">'''The Study Patients:''' Adult patients with severe, generalised, chronic periodontitis diagnosed with more than 30% of sites affected</span> | + | <span style="font-size: 110%;">'''The Study Patients:''' Adult patients with severe, generalised, chronic periodontitis diagnosed with more than 30% of sites affected</span> <span style="font-size: 110%; line-height: 1.5;">Control group (N = 10; 10 analysed): Standard treatment for periodontitis including scaling and root planing at five visits up to three months.</span> <span style="font-size: 110%; line-height: 1.5;">Experimental group (N = 10 ; 10 analysed): As above, plus twice daily HBOT for five days. Each session 72 minutes at 2.4ATA breathing 100% oxygen.</span> |
| − | <span style="font-size: 110%; line-height: 1.5;">Control group (N = 10; 10 analysed): Standard treatment for periodontitis including scaling and root planing at five visits up to three months.</span> | ||
| − | <span style="font-size: 110%; line-height: 1.5;">Experimental group (N = 10 ; 10 analysed): As above, plus twice daily HBOT for five days. Each session 72 minutes at 2.4ATA breathing 100% oxygen.</span> | ||
| − | + | '''<span style="font-size: 110%;">The Evidence:</span>''' | |
| − | {| | + | {| |
| − | |||
|- | |- | ||
| − | | | + | | <span>'''<span>Outcome</span>'''</span> |
| + | | | ||
| + | | <span>'''<span>Standard Group</span>'''</span> | ||
| + | | | ||
| + | | <span>'''<span>HBO Group</span>'''</span> | ||
| + | | <span>'''<span>Difference</span>'''</span> | ||
| + | | <span>'''<span>95% CI</span>'''</span> | ||
|- | |- | ||
| − | | '''<span | + | | |
| + | | '''<span>Mean</span>''' | ||
| + | | '''<span>SD</span>''' | ||
| + | | '''<span>Mean</span>''' | ||
| + | | '''<span>SD</span>''' | ||
| + | | ^ | ||
| + | | ^ | ||
|- | |- | ||
| − | | '''<span | + | | '''<span>Probing depth (mm) at 3 months</span>''' |
| + | | <span><span>5.5</span></span> | ||
| + | | <span><span>1.1</span></span> | ||
| + | | <span><span>3.7</span></span> | ||
| + | | <span><span>1.3</span></span> | ||
| + | | <span><span>1.8</span></span> | ||
| + | | <span><span style="font-size: 110%;">0.64 to 2.9</span></span> | ||
|- | |- | ||
| + | | '''<span>Clinical attachment level (mm) at 3 months</span>''' | ||
| + | | <span><span>5.7</span></span> | ||
| + | | <span><span>1.5</span></span> | ||
| + | | <span><span>3.8</span></span> | ||
| + | | <span><span>1.4</span></span> | ||
| + | | <span><span>1.9</span></span> | ||
| + | | <span><span style="font-size: 110%;">0.57 to 3.3</span></span> | ||
|} | |} | ||
| − | {| | + | {| |
| − | |||
|- | |- | ||
| − | | '''<span | + | | <span>'''<span>Non-Event Outcomes</span>'''</span> |
| + | | <span>'''<span>Time to outcome/s</span>'''</span> | ||
| + | | <span>'''<span>Control group</span>'''</span> | ||
| + | | <span>'''<span>Experimental group</span>'''</span> | ||
| + | | <span>'''<span>P-value</span>'''</span> | ||
|- | |- | ||
| − | | '''<span | + | | '''<span>Plaque index (PI)</span>''' |
| + | | <span><span>3 months</span></span> | ||
| + | | <span><span>45.2%</span></span> | ||
| + | | <span><span>32.2%</span></span> | ||
| + | | <span><span style="font-size: 110%;">>0.05</span></span> | ||
|- | |- | ||
| + | | '''<span>Bleeding on probing (BoP)</span>''' | ||
| + | | <span><span>3 months</span></span> | ||
| + | | <span><span>28.3%</span></span> | ||
| + | | <span><span>18.7%</span></span> | ||
| + | | <span><span style="font-size: 110%;">>0.05</span></span> | ||
|} | |} | ||
| − | + | ||
| + | | ||
| + | |||
| + | '''<span style="font-size: 110%;">Comments:</span>''' | ||
<span style="font-size: 110%;">1. Pilot study only, no sample size calculations made. Only 20 of 360 patients were eligible - most did not meet the inclusion criteria.</span> | <span style="font-size: 110%;">1. Pilot study only, no sample size calculations made. Only 20 of 360 patients were eligible - most did not meet the inclusion criteria.</span> | ||
| Line 48: | Line 87: | ||
<span style="font-size: 110%;">4. This trial only measured short-term effects and more work is necessary.</span> | <span style="font-size: 110%;">4. This trial only measured short-term effects and more work is necessary.</span> | ||
| − | <span style="font-size: 110%;">'''Appraised by:''' Mike Bennett, Prince of Wales Hospital ; Monday, 14 July 2014</span> | + | <span style="font-size: 110%;">'''Appraised by:''' Mike Bennett, Prince of Wales Hospital ; Monday, 14 July 2014</span> <span style="font-size: 110%; line-height: 1.5;">Email: m.bennett@unsw.edu.au</span> |
| − | <span style="font-size: 110%; line-height: 1.5;">Email: m.bennett@unsw.edu.au</span> | ||
<span style="font-size: 110%;">Kill or Update By: July 2017</span> | <span style="font-size: 110%;">Kill or Update By: July 2017</span> | ||
| − | [[File: | + | [[File:Sumhorsa.gif|center|Sumhorsa.gif]] |
| − | + | <p style="text-align: center;"> </p> <p style="text-align: center;"><span style="background-color: #ffffff; color: #7c00ff; font-size: 26px; text-align: center;">[[Miscellaneous|BACK]]</span></p> <p class="mw-empty-elt" style="text-align: center;"> </p> | |
| − | < | ||
| − | |||
| − | </ | ||
Revision as of 02:03, 7 April 2020
Some evidence that adjunctive HBOT improves outcome in severe chronic periodontitis at three months.
| 1. No difference at three months in the plaque index or proportion of sites bleeding on probing. 2. Significantly improved mean probing depth and clinical attachment level at three months |
Citation: Nogueira-Filho GR, Rosa BT, David-Neto JR. 3. Effects of hyperbaric oxygen therapy on the treatment of severe cases of periodontitis. UHM 2010;37(2):107-113.
Lead author's name and fax: Getulio Nogueira-Filho nogueira@cc.umanitoba.ca Three-part Clinical Question: For patients with severe periodontitis, does the adjunctive use of hyperbaric oxygen compared to standard therapy with scaling and root planing only, result in any improvement in outcome?
Search Terms: periodonitis, chronic severe; hyperbaric oxygen
The Study: Single-blinded concealed randomised controlled trial with intention-to-treat.
The Study Patients: Adult patients with severe, generalised, chronic periodontitis diagnosed with more than 30% of sites affected Control group (N = 10; 10 analysed): Standard treatment for periodontitis including scaling and root planing at five visits up to three months. Experimental group (N = 10 ; 10 analysed): As above, plus twice daily HBOT for five days. Each session 72 minutes at 2.4ATA breathing 100% oxygen.
The Evidence:
| Outcome | Standard Group | HBO Group | Difference | 95% CI | ||
| Mean | SD | Mean | SD | ^ | ^ | |
| Probing depth (mm) at 3 months | 5.5 | 1.1 | 3.7 | 1.3 | 1.8 | 0.64 to 2.9 |
| Clinical attachment level (mm) at 3 months | 5.7 | 1.5 | 3.8 | 1.4 | 1.9 | 0.57 to 3.3 |
| Non-Event Outcomes | Time to outcome/s | Control group | Experimental group | P-value |
| Plaque index (PI) | 3 months | 45.2% | 32.2% | >0.05 |
| Bleeding on probing (BoP) | 3 months | 28.3% | 18.7% | >0.05 |
Comments:
1. Pilot study only, no sample size calculations made. Only 20 of 360 patients were eligible - most did not meet the inclusion criteria.
2. The clinical importance of these findings is not clear. The plaque index has not been explained.
3. Improvements in probing depth and clinical attachment level may reflect improved fibroblast activity and bacterial killing.
4. This trial only measured short-term effects and more work is necessary.
Appraised by: Mike Bennett, Prince of Wales Hospital ; Monday, 14 July 2014 Email: m.bennett@unsw.edu.au
Kill or Update By: July 2017
BACK
