Perren
The addition of HBOT to standard wound care improved healing rate in diabetic foot ulcers.
| # The addition of HBOT improved wound area and depth at four weeks. |
- Citation/s: Perren S, Gatt A, Papanas N, Formosa C. Hyperbaric Oxygen Therapy in Ischemic Foot Ulcers in Type 2 Diabetes: A Clinical Trial. The Open Cardiovascular Medicine Journal 2018; 12:80.
Lead author's name and fax: Alfred.Gatt@um.edu.mt
- Three-part Clinical Question: For diabetic patients with a newly diagnosed ischemic foot ulcer, does the addition of HBOT to standard wound care result in improved healing?
Search Terms: diabetes, chronic wound, skin ulcer, ischaemia
- The Study: Non-blinded randomised controlled trial with intention-to-treat.
The Study Patients: Adults with type 2 diabetes and a newly diagnosed ischemic DFU.
Control group (N = 13; 13 analysed): Standard wound care including cleansing, optimised glycaemic control, treating infection, improving blood supply and relieving pressure on the wound site.
- Experimental group (N = 13; 13 analysed): SWC and daily 100% oxygen under increased atmospheric pressure (ATA not specified) for two hours from Monday to Friday to 40 sessions.
- The Evidence:
| Measure | HBOT Group | Control Group | Difference | 95% CI | ||
| ^ | Mean | SD | Mean | SD | ^ | ^ |
| Wound depth (cm) at week 4 | 0.71 | 0.25 | 1.34 | 0.29 | 0.63 | 0.41 to 0.85 |
| Wound surface area (cm2) at week 4 | 9.55 | 0.84 | 7.98 | 1.95 | 1.57 | 0.36 to 2.79 |
- Comments:
1. No sham treatment. The patient were randomized and matched for age, gender, DM duration, current medication, HbA1c, wound size and location using frequency distribution matching. Tight matching increases power by decreasing variability between groups but may eliminate allocation concealment.
2. Results given at four weeks, which seems to be after only half the HBOT treatments!
3. All investigations are made by the same investigator to ensure uniformity.
4. Standard wound care seems comprehensive
Appraised by: Cecilia Bondjers; Thursday, 1 November 2018 Email: cecilia.bondjers@vgregion.se
Kill or Update By: July 2021.
