Xu
Hyperbaric oxygenation may have reduced the incidence of sepsis associated with thermal burns.
- Clinical Bottom Line:
1. Apparent reduction in the incidence of sepsis following thermal burns with the addition of hyperbaric oxygenation to a therapeutic regime.
- Citation:
Xu N, Li Z, Luo X. [Effects of hyperbaric oxygen therapy on the changes in serum sIL-2R and Fn in severe burn patients]. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 1999; 15(3):220-223. Lead author's name and fax:
- Three-part Clinical Question: For patients with thermal burns, does the addition of hyperbaric oxygenation to a standard therapeutic regimen reduce the incidence of burn infection?
Search Terms: Hyperbaric oxygenation, Burns thermal
- The Study:
Non-blinded randomised controlled trial with intention-to-treat unknown. The Study Patients: Patients with >30% body surface area burns (or 3rd degree >10%BSA). Control group (N = 17): Not stated Experimental group (N = 25: HBO regimen not stated
- The Evidence:
| Non-Event Outcomes | Time to outcome | Control group | HBO group | P-value |
| Incidence of sepsis | 35 days | ? | Reduced | P <0.05 |
| Serum soluble interleukin 2 receptor | 35 days | ? | Not increased | P <0.05 |
| Plasma fibronectin | 35 days | ? | Not decreased | P < 0.01 |
- Comments:
1. Abstract only, little data given. 2. No details of randomization method, control therapy or hyperbaric schedule. 3. Clinical impact unknown. 4. Soluble interleukin 2 receptors in the serum are increased and plasma fibronectin is decreased in patients with burns and they are both apparently markers for burn infection. These markers were not significantly different in HBO treated subjects when compared to healthy, non-burned controls. 5. Article in Chinese, not yet available in translation.
- Appraised by: Mike Bennett and Juliette Leverment, Hyperbaric Medicine, Prince of Wales Hospital, Sydney ; Monday, 9 December 2002
Email: m.bennett@unsw.edu.au Kill or Update By: December 2024
