Difference between revisions of "Hu"
(Created page with " <span style="line-height:normal">'''<span style="font-size:18.0pt"><span style="font-family:" times="" new="" roman",serif"=""><span style="color:black">For sudden hearing lo...") |
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| − | <span style="line-height:normal">'''<span style="font-size:18.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:18.0pt"><span style="font-family:"><span style="color:black">For sudden hearing loss, the addition of hyperbaric oxygen at both daily and twice-daily schedules to 20 total treatments resulted in improved outcomes compared to standard treatment alone.</span></span></span>'''</span> |
| − | <span style="line-height:normal">'''<span style="font-size:18.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:18.0pt"><span style="font-family:"><span style="color:black"><span style="font-size:large;">Clinical bottom line:</span></span></span></span>'''</span> |
{| class="Table" style="width: 882px;" width="583" | {| class="Table" style="width: 882px;" width="583" | ||
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| − | <span style="font-size:large;"><span style="line-height:normal"><span style="height:59.05pt">'''<span style="font-family: | + | <span style="font-size:large;"><span style="line-height:normal"><span style="height:59.05pt">'''<span style="font-family:">1. There was a greater improvement in the proportion of patients with an effective response in the hyperbaric groups.<br/> 2. The mean improvement in hearing loss thresholds was greater with hyperbaric.</span>'''</span></span></span> |
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| − | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Citation/s:</span></span></span>'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">1. Hu Y, Chen H, Xiong J, Sun W. [The efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun;34(6):521-523;527. </span></span></span></span> |
| − | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Lead author's name and fax:</span></span></span>'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Chen Hongjiang, E-mail:13637809328@163.com</span></span></span></span> |
| − | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Three-part Clinical Question:</span></span></span>'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">For patients with ISSNHL, does the addition of hyperbaric oxygen to medical therapy result in improved hearing outcome?<br/> '''Search Terms:''' Hearing loss; steroids; intensive course</span></span></span></span> |
| − | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:" | + | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">The Study:</span></span></span>'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Non-blinded randomised controlled trial without intention-to-treat.<br/> '''The Study Patients:''' No details given except the diagnosis of 'sudden sensorineural hearing loss'.<br/> '''Control group''' (N = 42; 42 analysed): Standard medical management in this institution (14 day course, no details given).<br/> '''Experimental group''' (N = 65; 65 analysed): Either daily hyperbaric treatment or twice daily treatment to a total of 20 sessions - details not given.</span></span></span></span> |
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| + | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">The Evidence:</span></span></span>'''</span> | ||
{| class="Table" style="border: 1pt solid windowtext; width: 809px;" | {| class="Table" style="border: 1pt solid windowtext; width: 809px;" | ||
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| − | | style="width: 159px; border: 1pt solid windowtext;" width="110" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 159px; border: 1pt solid windowtext;" width="110" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Outcome</span></span>'''</span></p> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="66" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="66" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Time to Outcome</span></span>'''</span></p> |
| − | | style="width: 71px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 71px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Control group</span></span>'''</span></p> |
| − | | style="width: 76px; border: 1pt solid windowtext;" width="51" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 76px; border: 1pt solid windowtext;" width="51" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">HBO group</span></span>'''</span></p> |
| − | | style="width: 128px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 128px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Relative risk reduction</span></span>'''</span></p> |
| − | | style="width: 128px; border: 1pt solid windowtext;" width="121" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 128px; border: 1pt solid windowtext;" width="121" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Absolute risk reduction</span></span>'''</span></p> |
| − | | style="width: 112px; border: 1pt solid windowtext;" width="88" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 112px; border: 1pt solid windowtext;" width="88" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">NNT</span></span>'''</span></p> |
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| − | | rowspan="2" style="width: 159px; border: 1pt solid windowtext;" width="110" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | rowspan="2" style="width: 159px; border: 1pt solid windowtext;" width="110" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Effective treatment (not defined)</span></span>'''</span></p> |
| − | | style="width: 81px; border: 1pt solid windowtext;" width="66" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 81px; border: 1pt solid windowtext;" width="66" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">20 days</span></span></span></p> |
| − | | style="width: 71px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 71px; border: 1pt solid windowtext;" width="57" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">0.62</span></span></span></p> |
| − | | style="width: 76px; border: 1pt solid windowtext;" width="51" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 76px; border: 1pt solid windowtext;" width="51" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">0.80</span></span></span></p> |
| − | | style="width: 128px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 128px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">29%</span></span></span></p> |
| − | | style="width: 128px; border: 1pt solid windowtext;" width="121" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 128px; border: 1pt solid windowtext;" width="121" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">0.18</span></span></span></p> |
| − | | style="width: 112px; border: 1pt solid windowtext;" width="88" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 112px; border: 1pt solid windowtext;" width="88" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">6</span></span></span></p> |
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| − | | colspan="3" style="width: 242px; border: 1pt solid windowtext;" width="178" | <p align="right" style="margin-bottom:0cm; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | colspan="3" style="width: 242px; border: 1pt solid windowtext;" width="178" | <p align="right" style="margin-bottom:0cm; text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">95% CIs:</span></span></span></p> |
| − | | style="width: 128px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 128px; border: 1pt solid windowtext;" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">1% to 58%</span></span></span></p> |
| − | | style="width: 128px; border: 1pt solid windowtext;" width="121" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 128px; border: 1pt solid windowtext;" width="121" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">0.005 to 0.36</span></span></span></p> |
| − | | style="width: 112px; border: 1pt solid windowtext;" width="88" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width: 112px; border: 1pt solid windowtext;" width="88" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">3 to 206</span></span></span></p> |
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{| class="Table" style="border:solid windowtext 1.0pt" | {| class="Table" style="border:solid windowtext 1.0pt" | ||
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| − | | rowspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | rowspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Measure</span></span>'''</span></p> |
| − | | colspan="2" style="width:85.2pt; border:solid windowtext 1.0pt" width="114" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | colspan="2" style="width:85.2pt; border:solid windowtext 1.0pt" width="114" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Control Group</span></span>'''</span></p> |
| − | | colspan="2" style="width:85.8pt; border:solid windowtext 1.0pt" width="114" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | colspan="2" style="width:85.8pt; border:solid windowtext 1.0pt" width="114" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">HBO Group</span></span>'''</span></p> |
| − | | rowspan="2" style="width:69.35pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | rowspan="2" style="width:69.35pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Difference</span></span>'''</span></p> |
| − | | rowspan="2" style="width:80.25pt; border:solid windowtext 1.0pt" width="107" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | rowspan="2" style="width:80.25pt; border:solid windowtext 1.0pt" width="107" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">95% CI</span></span>'''</span></p> |
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| − | | style="width:37.25pt; border:solid windowtext 1.0pt" width="50" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width:37.25pt; border:solid windowtext 1.0pt" width="50" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Mean</span></span>'''</span></p> |
| − | | style="width:46.45pt; border:solid windowtext 1.0pt" width="62" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width:46.45pt; border:solid windowtext 1.0pt" width="62" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">SD</span></span>'''</span></p> |
| − | | style="width:43.25pt; border:solid windowtext 1.0pt" width="58" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width:43.25pt; border:solid windowtext 1.0pt" width="58" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Mean</span></span>'''</span></p> |
| − | | style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | | style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">SD</span></span>'''</span></p> |
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| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Mean hearing recovery at 20 days (dB threshold)</span></span>'''</span> |
| − | | style="width:37.25pt; border:solid windowtext 1.0pt" width="50" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:37.25pt; border:solid windowtext 1.0pt" width="50" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">17.6</span></span></span></p> |
| − | | style="width:46.45pt; border:solid windowtext 1.0pt" width="62" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:46.45pt; border:solid windowtext 1.0pt" width="62" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">18.5</span></span></span></p> |
| − | | style="width:43.25pt; border:solid windowtext 1.0pt" width="58" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:43.25pt; border:solid windowtext 1.0pt" width="58" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">27.2</span></span></span></p> |
| − | | style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:41.05pt; border:solid windowtext 1.0pt" width="55" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">17.6</span></span></span></p> |
| − | | style="width:69.35pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:69.35pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">9.60</span></span></span></p> |
| − | | style="width:80.25pt; border:solid windowtext 1.0pt" width="107" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | | style="width:80.25pt; border:solid windowtext 1.0pt" width="107" | <p align="center" style="margin-bottom:0cm; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">116.9 to 136.1</span></span></span></p> |
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| − | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Comments:</span></span></span>'''<br/> <span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">1. Full report in Chinese. This information taken from abstract.<br/> 2. Pseudorandom allocation by sequential allocation to groups (this does not explain the disparity in group sizes).</span></span></span></span> |
| − | <span style="line-height:normal"><span style="font-size:13.5pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">3. Awaiting full translation. Wide confidence limits.</span></span></span></span> |
| − | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Appraised by:</span></span></span>'''<span style="font-size:13.5pt"><span style="font-family:"><span style="color:black">Mike Bennett Email m.bennett@unsw.edu.au; Saturday, 6 February 2021<br/> '''Kill or Update By:''' June 2022</span></span></span></span> |
| + | <p style="text-align: center;"> </p> <p style="text-align: center;"> </p> <p style="text-align: center;">http://hboevidence.wikis.unsw.edu.au/images/8/89/Sumhorsa.gif</p> <p style="text-align: center;"> </p> <p style="text-align: center;"><span style="font-size:xx-large;">[[Audiovestibular|BACK]]</span></p> | ||
Latest revision as of 02:06, 30 September 2021
For sudden hearing loss, the addition of hyperbaric oxygen at both daily and twice-daily schedules to 20 total treatments resulted in improved outcomes compared to standard treatment alone.
Clinical bottom line:
|
1. There was a greater improvement in the proportion of patients with an effective response in the hyperbaric groups. |
Citation/s:1. Hu Y, Chen H, Xiong J, Sun W. [The efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun;34(6):521-523;527.
Lead author's name and fax:Chen Hongjiang, E-mail:13637809328@163.com
Three-part Clinical Question:For patients with ISSNHL, does the addition of hyperbaric oxygen to medical therapy result in improved hearing outcome?
Search Terms: Hearing loss; steroids; intensive course
The Study:Non-blinded randomised controlled trial without intention-to-treat.
The Study Patients: No details given except the diagnosis of 'sudden sensorineural hearing loss'.
Control group (N = 42; 42 analysed): Standard medical management in this institution (14 day course, no details given).
Experimental group (N = 65; 65 analysed): Either daily hyperbaric treatment or twice daily treatment to a total of 20 sessions - details not given.
The Evidence:
Outcome |
Time to Outcome |
Control group |
HBO group |
Relative risk reduction |
Absolute risk reduction |
NNT |
Effective treatment (not defined) |
20 days |
0.62 |
0.80 |
29% |
0.18 |
6 |
95% CIs: |
1% to 58% |
0.005 to 0.36 |
3 to 206 | |||
Measure |
Control Group |
HBO Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Mean hearing recovery at 20 days (dB threshold) |
17.6 |
18.5 |
27.2 |
17.6 |
9.60 |
116.9 to 136.1 |
Comments:
1. Full report in Chinese. This information taken from abstract.
2. Pseudorandom allocation by sequential allocation to groups (this does not explain the disparity in group sizes).
3. Awaiting full translation. Wide confidence limits.
Appraised by:Mike Bennett Email m.bennett@unsw.edu.au; Saturday, 6 February 2021
Kill or Update By: June 2022
