Hu

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For sudden hearing loss, the addition of hyperbaric oxygen at both daily and twice-daily schedules to 20 total treatments resulted in improved outcomes compared to standard treatment alone.

Clinical bottom line:

1. There was a greater improvement in the proportion of patients with an effective response in the hyperbaric groups.
2. The mean improvement in hearing loss thresholds was greater with hyperbaric.


Citation/s:1. Hu Y, Chen H, Xiong J, Sun W. [The efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Jun;34(6):521-523;527.  

Lead author's name and fax:Chen Hongjiang, E-mail:13637809328@163.com

Three-part Clinical Question:For patients with ISSNHL, does the addition of hyperbaric oxygen to medical therapy result in improved hearing outcome?
Search Terms: Hearing loss; steroids; intensive course

The Study:Non-blinded randomised controlled trial without intention-to-treat.
The Study Patients: No details given except the diagnosis of 'sudden sensorineural hearing loss'.
Control group (N = 42; 42 analysed): Standard medical management in this institution (14 day course, no details given).
Experimental group (N = 65; 65 analysed): Either daily hyperbaric treatment or twice daily treatment to a total of 20 sessions - details not given.

The Evidence:

Outcome

Time to Outcome

Control group

HBO group

Relative risk reduction

Absolute risk reduction

NNT

Effective treatment (not defined)

20 days

0.62

0.80

29%

0.18

6

95% CIs:

1% to 58%

0.005 to 0.36

3 to 206

 

Measure

Control Group

HBO Group

Difference

95% CI

Mean

SD

Mean

SD

Mean hearing recovery at 20 days (dB threshold)

17.6

18.5

27.2

17.6

9.60

116.9 to 136.1

Comments:
1. Full report in Chinese. This information taken from abstract.
2. Pseudorandom allocation by sequential allocation to groups (this does not explain the disparity in group sizes).

3. Awaiting full translation. Wide confidence limits.

Appraised by:Mike Bennett Email m.bennett@unsw.edu.au; Saturday, 6 February 2021
Kill or Update By: June 2022

 

 

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