Difference between revisions of "Vlahovic"
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| − | <span style="line-height:normal">'''<span style="font-size:18.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:18.0pt"><span style="font-family:"><span style="color:#001133">Hyperbaric oxygenation did not affect measures of left ventricular stiffness, but was associated with lower enzyme levels and lower requirement for beta-blockers and anti-arrhythmics in patients with acute myocardial infarction</span></span></span>'''</span> |
| − | <span style="line-height:normal">'''<span style="font-size:14.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:14.0pt"><span style="font-family:"><span style="color:#001133">Clinical Bottom line:</span></span></span>'''</span> |
| − | <span style="line-height:normal"><span style="font-size:14.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:14.0pt"><span style="font-family:"><span style="color:#001133">1. No significant effect of HBOT on left ventricular stiffness assessed by echocardiography.</span></span></span><br/> <span style="font-size:14.0pt"><span style="font-family:"><span style="color:#001133">2. HBOT may have resulted in smaller infarct size.</span></span></span></span> |
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| + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Citation/s:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">1. Vlahovic A, Neskovic AN, Dekleva M, Putnikovic B, Popovic ZB, Otasevic P, Ostojic M. Hyperbaric oxygen treatment does not affect left ventricular chamber stiffness after myocardial infarction treated with thrombolysis. American Heart Journal 2004; 148:J1-J7.</span></span></span></span></span> | ||
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| − | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Lead author's name and email:</span></span></span>''' <span style="font-size:12.0pt"><span style="font-family:"><span style="color:#3366bb">[mailto:neskovic@hotmail.com neskovic@hotmail.com]</span></span></span></span></span> | |
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| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | ||
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| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Three-part Clinical Question:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">For patients with an acute myocardial infarction, does the adjunctive administration of hyperbaric oxygen following thrombolysis, compared to thrombolysis alone, result in any improvement in left ventricular stiffness or infarct size?</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Search Terms:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">myocardial infarction, cardiac enzymes, echocardiography</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">The Study:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Non-blinded randomised controlled trial with intention-to-treat.</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">The Study Patients:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Proven acute MI in patients under 70 years with ECG changes and enzyme rise, and without heart failure or malignant arrhythmias.</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Control group</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">(N = 37; 37 analysed): Streptokinase 1.5m IU at mean time of 2.4 hours.</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Experimental group</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">(N = 37; 37 analysed): Streptokinase as above (mean time to treatment 3.0 hours), followed by 100% oxygen at 2 ATA for 60 minutes (mean time to treatment 13 hours).</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">The Evidence:</span></span></span>'''</span></span> |
{| class="Table" style="background:white; border-collapse:collapse; border:solid windowtext 1.0pt" | {| class="Table" style="background:white; border-collapse:collapse; border:solid windowtext 1.0pt" | ||
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| − | | style="width:91.9pt; border:solid windowtext 1.0pt; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:91.9pt; border:solid windowtext 1.0pt; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Outcome</span></span>'''</span></p> |
| − | | style="width:49.6pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:49.6pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Time to Outcome</span></span>'''</span></p> |
| − | | style="width:42.55pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:42.55pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Control group</span></span>'''</span></p> |
| − | | style="width:35.45pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:35.45pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">HBOT group</span></span>'''</span></p> |
| − | | style="width:63.75pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:63.75pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Relative risk reduction</span></span>'''</span></p> |
| − | | style="width:78.0pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:78.0pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Absolute risk reduction</span></span>'''</span></p> |
| − | | style="width:89.55pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:89.55pt; border:solid windowtext 1.0pt; border-left:none; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Number needed to treat</span></span>'''</span></p> |
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| rowspan="2" style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | | rowspan="2" style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | ||
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Needed intravenous beta-blockers</span></span>'''</span> |
| − | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">not known</span></span></span></p> |
| − | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.16</span></span></span></p> |
| − | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.03</span></span></span></p> |
| − | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">83%</span></span></span></p> |
| − | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.14</span></span></span></p> |
| − | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">7</span></span></span></p> |
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| − | | colspan="3" style="width:127.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="170" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | colspan="3" style="width:127.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="170" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">95% CI:</span></span></span></p> |
| − | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">3% to 100%</span></span></span></p> |
| − | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.01 to 0.27</span></span></span></p> |
| − | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">4 to 189</span></span></span></p> |
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| rowspan="2" style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | | rowspan="2" style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | ||
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Needed antiarrhythmics</span></span>'''</span> |
| − | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">not known</span></span></span></p> |
| − | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.30</span></span></span></p> |
| − | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.11</span></span></span></p> |
| − | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">64%</span></span></span></p> |
| − | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.19</span></span></span></p> |
| − | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">5</span></span></span></p> |
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| − | | colspan="3" style="width:127.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="170" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | colspan="3" style="width:127.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="170" | <p align="right" style="margin-bottom:.0001pt; text-align:right; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">95% CI:</span></span></span></p> |
| − | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">4% to 100%</span></span></span></p> |
| − | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.01 to 0.37</span></span></span></p> |
| − | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">3 to 91</span></span></span></p> |
|- | |- | ||
| colspan="7" style="width:450.8pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="601" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"> </p> | | colspan="7" style="width:450.8pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="601" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"> </p> | ||
|- | |- | ||
| − | | rowspan="2" style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | rowspan="2" style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Measure</span></span>'''</span></p> |
| − | | colspan="2" style="width:92.15pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | colspan="2" style="width:92.15pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Control Group</span></span>'''</span></p> |
| − | | colspan="2" style="width:99.2pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="132" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | colspan="2" style="width:99.2pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="132" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Hyperbaric Group</span></span>'''</span></p> |
| − | | rowspan="2" style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | rowspan="2" style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Difference</span></span>'''</span></p> |
| − | | rowspan="2" style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | rowspan="2" style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">95% CI</span></span>'''</span></p> |
|- | |- | ||
| − | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Mean</span></span>'''</span></p> |
| − | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">SD</span></span>'''</span></p> |
| − | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Mean</span></span>'''</span></p> |
| − | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">SD</span></span>'''</span></p> |
|- | |- | ||
| style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | | style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | ||
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Peak creatine phosphokinase level (IU)</span></span>'''</span> |
| − | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">1529</span></span></span></p> |
| − | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">1187</span></span></span></p> |
| − | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">989</span></span></span></p> |
| − | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">643</span></span></span></p> |
| − | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">540</span></span></span></p> |
| − | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">98.2 to 981.9</span></span></span></p> |
|- | |- | ||
| style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | | style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | ||
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Wall motion score index</span></span>'''</span> |
| − | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:49.6pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="66" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">1.52</span></span></span></p> |
| − | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:42.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="57" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.7</span></span></span></p> |
| − | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:35.45pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="47" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">1.38</span></span></span></p> |
| − | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:63.75pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="85" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.5</span></span></span></p> |
| − | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="104" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">0.14</span></span></span></p> |
| − | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">-0.14 to 0.42</span></span></span></p> |
|- | |- | ||
| style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | | style="width:91.9pt; border:solid windowtext 1.0pt; border-top:none; background:white" width="123" | | ||
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:"><span style="color:#001133">Deceleration time (early filling velocity)</span></span>'''</span> |
| − | | colspan="2" style="width:92.15pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | colspan="2" style="width:92.15pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="123" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">Not given</span></span></span></p> |
| − | | colspan="2" style="width:99.2pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="132" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | colspan="2" style="width:99.2pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="132" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">Not given</span></span></span></p> |
| style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; padding:0cm 0cm 0cm 0cm; background:white" width="104" | | | style="width:78.0pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; padding:0cm 0cm 0cm 0cm; background:white" width="104" | | ||
| − | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family: | + | | style="width:89.55pt; border-top:none; border-left:none; border-bottom:solid windowtext 1.0pt; border-right:solid windowtext 1.0pt; background:white" width="119" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:0cm 0cm 0cm 0cm"><span style="line-height:normal"><span style="font-family:"><span style="color:#001133">P = 0.87</span></span></span></p> |
|} | |} | ||
| | ||
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Comments:</span></span></span>'''</span></span> |
| − | <span style="background:white"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">1. Generally this group of patients had small infarcts with a mild degree of systolic and diastolic dysfunction. The effect of HBOT in a higher risk group is not clear from this study.</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">2. There is a mean time from pain onset to HBOT of 13 hours, and this may mean many patients missed an early time window when HBOT may have been more efficaceous.</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">3. Only an indirect measure of infarct size was measured in this study - CK levels.</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Appraised by:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Mike Bennett, POWH; m.bennett@unsw.edu.au; Friday, 6 July 2007</span></span></span></span></span> |
| − | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="background:white"><span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">Kill or Update By:</span></span></span>'''<span style="font-size:12.0pt"><span style="font-family:"><span style="color:#001133">June 2024</span></span></span></span></span> |
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Latest revision as of 04:01, 22 August 2022
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Hyperbaric oxygenation did not affect measures of left ventricular stiffness, but was associated with lower enzyme levels and lower requirement for beta-blockers and anti-arrhythmics in patients with acute myocardial infarction Clinical Bottom line: 1. No significant effect of HBOT on left ventricular stiffness assessed by echocardiography. |
Citation/s:1. Vlahovic A, Neskovic AN, Dekleva M, Putnikovic B, Popovic ZB, Otasevic P, Ostojic M. Hyperbaric oxygen treatment does not affect left ventricular chamber stiffness after myocardial infarction treated with thrombolysis. American Heart Journal 2004; 148:J1-J7.
Lead author's name and email: neskovic@hotmail.com
Three-part Clinical Question:For patients with an acute myocardial infarction, does the adjunctive administration of hyperbaric oxygen following thrombolysis, compared to thrombolysis alone, result in any improvement in left ventricular stiffness or infarct size?
Search Terms:myocardial infarction, cardiac enzymes, echocardiography
The Study:Non-blinded randomised controlled trial with intention-to-treat.
The Study Patients:Proven acute MI in patients under 70 years with ECG changes and enzyme rise, and without heart failure or malignant arrhythmias.
Control group(N = 37; 37 analysed): Streptokinase 1.5m IU at mean time of 2.4 hours.
Experimental group(N = 37; 37 analysed): Streptokinase as above (mean time to treatment 3.0 hours), followed by 100% oxygen at 2 ATA for 60 minutes (mean time to treatment 13 hours).
The Evidence:
Outcome |
Time to Outcome |
Control group |
HBOT group |
Relative risk reduction |
Absolute risk reduction |
Number needed to treat |
|
Needed intravenous beta-blockers |
not known |
0.16 |
0.03 |
83% |
0.14 |
7 |
95% CI: |
3% to 100% |
0.01 to 0.27 |
4 to 189 | |||
|
Needed antiarrhythmics |
not known |
0.30 |
0.11 |
64% |
0.19 |
5 |
95% CI: |
4% to 100% |
0.01 to 0.37 |
3 to 91 | |||
| ||||||
Measure |
Control Group |
Hyperbaric Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Peak creatine phosphokinase level (IU) |
1529 |
1187 |
989 |
643 |
540 |
98.2 to 981.9 |
|
Wall motion score index |
1.52 |
0.7 |
1.38 |
0.5 |
0.14 |
-0.14 to 0.42 |
|
Deceleration time (early filling velocity) |
Not given |
Not given |
P = 0.87 | |||
Comments:
1. Generally this group of patients had small infarcts with a mild degree of systolic and diastolic dysfunction. The effect of HBOT in a higher risk group is not clear from this study.
2. There is a mean time from pain onset to HBOT of 13 hours, and this may mean many patients missed an early time window when HBOT may have been more efficaceous.
3. Only an indirect measure of infarct size was measured in this study - CK levels.
Appraised by:Mike Bennett, POWH; m.bennett@unsw.edu.au; Friday, 6 July 2007
Kill or Update By:June 2024
