Woo

Revision as of 22:55, 6 February 2022 by M.bennett (talk | contribs)

A single hyperbaric oxygen exposure may reduce inflammatory and muscle damage markers following exercise in normal conditions.

 

Clinical bottom line:

  1. Clinical significance unclear.
  2. Post-exercise HBO exposure may reduce markers of inflammation and muscle damage, but results uncertain.
  3. Also some modest reduction in oxidative stress possible. 

Citation: Woo J, Min JH, Lee YH, Roh HT. Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study. International Journal of Environmental Research and Public Health. 2020 October 17:7377.

 

Lead author’s name and email: Jinhee Woo : jop9508@naver.com

 

Three-part clinical question: For individuals exercising in either air or hypobaric hypoxic environments, does a later rest period breathing hyperbaric oxygen, compared to air, result in reduced serum inflammatory, oxidative and muscle damage markers?

 Search terms: Exercise, oxidative stress, muscle damage

 

The study: Non-blinded randomised controlled trial with intention-to-treat.

The study patients: Healthy male volunteers with BMI under 30 kg/m2.

 Control group: (N = 6; 6 analysed): Treadmill run for 60 minutes at 75-80% max heart rate breathing air at 1  (PiO2 = 0.2 ATA) followed by air breathing rest for 60 minutes.

 Experimental group: (N = 6; 6 analysed): As above for exercise, but breathing 100% oxygen at 2.5 ATA for 60 minutes.

 

The evidence

Measure

Air Group

HBO Group

Difference

95% CI

Mean

SD

Mean

SD

Interleukin-6 (pg/ml at 60 mins)

911

111

900

53

11

-9720 to 9742

Biological antioxidant potential (BAP) (micromole/L at 60 mins)

2773

182

2545

227

228

-54217 to 54673

Creatine Kinase (u/L)

255

59

227

64

28

-4844 to 4900

Note: Interleukin-6 used as marker of inflammation, BAP as a measure of oxidative stress, CK as an indicator of muscle damage

Comments:

  1. Clinical significance of the findings is not clear.
  2. Authors also tested a group exercising in hypoxia (PiO2 = 0.1 ATA) and then recovered in HBO conditions. Not discussed here.
  3. All outcome data here is read from graphical display of results. The report is rather confusing.
  4. Described as a pilot study, but definitive plans are vague.

 

Appraised by: Bosco Tran bosco.tran@student.unsw.edu.au

Kill or update by: February 2025