Difference between revisions of "Yuan 2010"
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− | == <span style="font-size: | + | == <span style="font-size:xx-large;">Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function</span> == |
=== <span style="font-size: 14pt;">Clinical bottom line:</span> === | === <span style="font-size: 14pt;">Clinical bottom line:</span> === | ||
− | {| | + | {| style="width: 664px;" |
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− | | '''1. Erectile function scores declined less following postoperative HBOT than a sham treatment.''' | + | | style="width: 652px;" | '''1. Erectile function scores declined less following postoperative HBOT than a sham treatment.''' |
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'''Citation/s: '''1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761 | '''Citation/s: '''1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761 | ||
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− | ''' | + | '''Lead author's name''':'''Yang:''' yang_louyan@yahoo.cn |
− | ''' | + | '''Three-part Clinical Question: '''Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction. |
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+ | '''Search Terms: '''erectile dysfunction. urethral reconstruction, urethral stricture | ||
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'''The Study: '''Double blinded, pseudo-randomised trial (alternate allocation) with intention-to-treat. | '''The Study: '''Double blinded, pseudo-randomised trial (alternate allocation) with intention-to-treat. | ||
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T'''he Study Patients: '''Men with posterior urethral stricture and having operative reconstruction. | T'''he Study Patients: '''Men with posterior urethral stricture and having operative reconstruction. | ||
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<span style="line-height: 1.5;">'''Experimental group:''' </span><span style="line-height: 1.5;">(N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.</span> | <span style="line-height: 1.5;">'''Experimental group:''' </span><span style="line-height: 1.5;">(N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.</span> | ||
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'''The Evidence:''' | '''The Evidence:''' | ||
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{| class="Table" style="border:solid windowtext 1.0pt" | {| class="Table" style="border:solid windowtext 1.0pt" | ||
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− | | style="border:solid windowtext 1.0pt" | + | | style="width:153.2pt; border:solid windowtext 1.0pt" width="207" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Measure'''</p> |
− | + | | colspan="2" style="width:76.45pt; border:solid windowtext 1.0pt" width="104" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Air Group'''</p> | |
− | + | | colspan="2" style="width:76.45pt; border:solid windowtext 1.0pt" width="104" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''HBOT group'''</p> | |
− | | style=" | + | | style="width:59.35pt; border:solid windowtext 1.0pt" width="81" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Difference'''</p> |
− | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''95% CI'''</p> | |
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− | | style="border:solid windowtext 1.0pt | + | | style="width:153.2pt; border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" width="207" | |
− | + | | style="width:41.0pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Mean'''</p> | |
− | + | | style="width:33.95pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''SD'''</p> | |
− | | style="border:solid windowtext 1.0pt" | + | | style="width:41.05pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''Mean'''</p> |
− | + | | style="width:33.9pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''SD'''</p> | |
− | + | | style="width:59.35pt; border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" width="81" | | |
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| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | | style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | ||
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− | + | '''Total IIEF* scores at 3 months (score 0 worst - 70 best)''' | |
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+ | | style="width:41.0pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">52.8</p> | ||
+ | | style="width:33.95pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">5.2</p> | ||
+ | | style="width:41.05pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">61.3</p> | ||
+ | | style="width:33.9pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">4.1</p> | ||
+ | | style="width:59.35pt; border:solid windowtext 1.0pt" width="81" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">-8.5</p> | ||
+ | | style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">-12.4 to -4.6</p> | ||
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− | | style="border:solid windowtext 1.0pt" | + | | style="width:153.2pt; border:solid windowtext 1.0pt" width="207" | |
− | + | '''Erectile function domain at 3 months (0 - 25)''' | |
− | | style="border:solid windowtext 1.0pt" | | + | | style="width:41.0pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">19.5</p> |
− | < | + | | style="width:33.95pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">2.9</p> |
+ | | style="width:41.05pt; border:solid windowtext 1.0pt" width="57" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">23.8</p> | ||
+ | | style="width:33.9pt; border:solid windowtext 1.0pt" width="47" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">1.9</p> | ||
+ | | style="width:59.35pt; border:solid windowtext 1.0pt" width="81" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">-4.3</p> | ||
+ | | style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">-6.3 to -2.2</p> | ||
+ | |} | ||
− | + | *<span style="tab-stops:list 36.0pt">IIEF = International Index of Erectile Function</span> | |
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− | + | '''Appraised by:''''':''''''M Bennett '''m.bennett@unsw.edu.au''' ; Friday, 16 January 2015''' | |
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− | '''Appraised by''''''''' | ||
− | '''<span style="line-height: 1.5;">Kill or Update By:</span>'''<span style="line-height: 1.5;"> | + | '''<span style="line-height: 1.5;">Kill or Update By:</span>'''<span style="line-height: 1.5;">J uly 2021</span> |
[[File:Sumhorsa.gif|center|Sumhorsa.gif]] | [[File:Sumhorsa.gif|center|Sumhorsa.gif]] | ||
<span style="display: block; text-align: center;"><span style="font-size: 230%;">[[Flaps_and_grafts|BACK]]</span></span> | <span style="display: block; text-align: center;"><span style="font-size: 230%;">[[Flaps_and_grafts|BACK]]</span></span> |
Latest revision as of 03:25, 17 August 2022
Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function
Clinical bottom line:
1. Erectile function scores declined less following postoperative HBOT than a sham treatment. |
Citation/s: 1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761
Lead author's name:Yang: yang_louyan@yahoo.cn
Three-part Clinical Question: Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.
Search Terms: erectile dysfunction. urethral reconstruction, urethral stricture
The Study: Double blinded, pseudo-randomised trial (alternate allocation) with intention-to-treat.
The Study Patients: Men with posterior urethral stricture and having operative reconstruction.
Control group: (N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.
Experimental group: (N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.
The Evidence:
Measure |
Air Group |
HBOT group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD |
|||
Total IIEF* scores at 3 months (score 0 worst - 70 best) |
52.8 |
5.2 |
61.3 |
4.1 |
-8.5 |
-12.4 to -4.6 |
Erectile function domain at 3 months (0 - 25) |
19.5 |
2.9 |
23.8 |
1.9 |
-4.3 |
-6.3 to -2.2 |
- IIEF = International Index of Erectile Function
Comments:
1. Not truly randomized. Alternate allocation following reconstruction.
2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts).
3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores.
4. Unpressurized sham - not known if this was effective.
5. Only a three month study. Long term effects not known.
Appraised by::'M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015
Kill or Update By:J uly 2021