Gesell
No evidence for benefit of hyperbaric oxygen therapy in brain radionecrosis (early interim report)
| Clinical Bottom Line: 1. 5 of 7 patients have suffered adverse events |
Citation/s: Gesell LB, Warnick RE, Brenerman JC, Vogt CJ, Lindsell CJ. A randomized, controlled trial of hyperbaric oxygen therapy for brain radionecrosis. Undersea and Hyperbaric Medicine, 2005. 32(4): 235-236
Three-part Clinical Question: For patients with brain radionecrosis, does hyperbaric oxygen therapy improve functional outcome? Search Terms: Radiation injury, Brain tumour, Neuropsychiatric testing
The Study:Non-blinded randomised controlled trial intention-to-treat unknown.
The Study Patients: PET-scan confirmed brain radionecrosis on steroids at a dose that cannot be tapered down
Control group (N = ?): Steroid treatment, dose adjusted to oedema volume and Karnofsky score, for 3 months
Experimental group (N = ?): As above, plus 60 treatments of 100% oxygen breathing at an unspecified pressure on an ‘accelerated air break’ protocol
The Evidence:
| Outcome | Time to outcome | Total |
| Adverse events | unknown | 5 of 7 patients enrolled |
Comments:
1. Abstract only
2. 7 patients enrolled, allocation unknown
3. No discussion of randomization procedure, blinding, or allocation concealment
4. Severe nature of disease and co-morbidities threaten to disrupt this trial
Appraised by: A/Prof Mike Bennett, Dr Sean Hopson Department of Diving and Hyperbaric Medicine Prince of Wales Hospital Sydney ; Friday, 22 September 2006Email: [m.bennett@unsw.edu.au]
Kill or Update By: December 2020
