Hadanny
Intervention with hyperbaric oxygen was associated with improved cognition compared to doing nothing
Clinical bottom line:
|
1. HBO group improved in some outcomes during the study period but this was not seen in the no contact group. May be a participation effect. |
Citation/s:1.Hadanny A, Malka D, Gil S, Rahav B-G, Merav C, Kobi D, Hachmo Y, Ramzia AH, Fishlev G, Lang E, Polak N, Keren D, Friedman M, Sigal T, Yonatan Z, Bechor Y, Efrati S Cognitive enhancement of healthy older adults with hyperbaric oxygen: A randomized controlled trial. Ageing 2020;12(13):13740
Lead author's name and fax: Amir Hadanny email: amir.had@gmail.com
Three-part Clinical Question:For healthy individuals older than 63, does a course of hyperbaric oxygen, compared to no treatment, result in any cognitive enhancement?
Search Terms: Ageing; dementia; cognition
The Study:Non-blinded randomised controlled trial without intention-to-treat.
The Study Patients: Healthy individuals aged >63 years.
Control group (N = 35 ; 32 analysed): No intervention or contact.
Experimental group (N = 35 ; 29 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily (Mon to Fri) to a total of 60 sessions.
The Evidence:
Measure |
No contact group |
HBOT Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Global cognitive score |
103 |
8.3 |
110.6 |
6.8 |
7.6 |
-22.0 to 37.1 |
|
Executive function percentile |
73.4 |
29.3 |
88.3 |
16.8 |
14.9 |
-285.2 to 315.0 |
Comments:
1. Study based on the association of ageing with both cognitive decline and falling regional cerebral blood flow. Authors assume cause and effect in operation.
2. 30 of 100 individuals contacted did not participate and nine of the remaining 70 were not included in results.
3. Short-term outcome at end of treatment period only. Long course of hyperbaric – 60 treatments. Not clear how this was chosen. It is not clear what min and max scores are possible from the outcome measures used (commercial tools).
4. No between-group comparisons are given, only the findings within each group. Some baseline differences between groups might be important (e.g. executive function 64.9 (control) versus 70 (HBO)).. Sample size based on five point improvement in cognitive function with HBOT versus 2 points in control. It is not clear the authors have tested for this differnce. They used a group by time interaction test rather thana simple comparison of means as suggested in their analysis plan.
Appraised by:Mike Bennett m.bennett@unsw.edu.au; Thursday, 1 April 2021
Kill or Update By:April 2024
