Sanchez
The addition of hyperbaric oxygen to a drug regimen of pentoxifylline and tocopherol for the treatment of neck radiation fibrosis resulted in improved LENT-SOMA
Clinical bottom line:
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1. The addition of hyperbaric oxygen improved outcome at three and six months |
Citation/s:
1.Sanchez CO, Lugo YG, Sánchez LO, Varela LD, Calero JJ, Romero PP. Treatment of radiation-induced cervical fibrosis with pentoxifylline-tocoferol and hyperbaric oxygen. Reports of Practical Oncology & Radiotherapy. 2013(18):S111
Lead author's name and fax: No details
Three-part Clinical Question:For patients with radiation fibrosis to the head and neck, does the addition of hyperbaric oxygen to the administration of pentoxifylline-tocopherol improve the response to treatment?
Search Terms: Pentoxifylline; radiation; head and neck cancer
The Study: Non-blinded randomised controlled trial without intention-to-treat.
The Study Patients: Patients with at least Grade-II radiation fibrosis in the neck according to LENT-SOMA scale.
Control group (N = 13; 13 analysed): Pentoxiffyline 400mg bd and tocopherol 400mg bd for six months.
Experimental group (N = 13; 13 analysed): As above plus 100% oxygen breathing at 2.4 ATA for 90 minutes daily five times per week to a total of 25 treatments from week 3 to 9.
The Evidence:
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Comments:
1. 37 patients were randomised but no allocation details or results for 11 of these.
2. Not clear what the result would be compared to neither intervention
3. Abstract only with few details. No full account published of which I am aware.
Appraised by:Mike Bennett m.bennett@unsw.edu.au ; Monday, 14 December 2020
Kill or Update By: December 2022
