Senol

Hyperbaric oxygenation did not improve post-dural puncture headache after spinal anaesthesia.  

1. Hyperbaric oxygen did not reduce pain scores compared to a sham procedure at any time between one and five days  

Citation/s: 1. Senol MG, Kendirli MT, Sen A, Karadurmus N, Kendirli N, Sen H, Saracoglu M. Efficacy of hyperbaric oxygen therapy in post-dural puncture headache. TURKIYE KLINIKLERI TIP BILIMLERI DERGISI. 2009 Dec 1;29(6):1618-22.  
Lead author's name and fax: Mehmet Senol: mgsenol@yahoo.com  

Three-part Clinical Question: Does hyperbaric oxygen improve post lumbar puncture headache? 
Search Terms: Post-dural-puncture headache; spinal headache; normobaric 

The Study: 
Double-blinded randomised controlled trial with intention-to-treat. 
The Study Patients: Patients complaining of post dural puncture headache after spinal anaesthesia.  
Control group (N = 10; 10 analysed): Nil specific therapy - air-breathing only.as a sham procedure daily for six days 
Experimental group (N = 10; 10 analysed): As above but 100% oxygen breathing at 2.0 ATA for 45 minutes.  

The Evidence: 

Measure 

Sham Group 

HBOT Group 

Difference 

95% CI 

Mean 

SD 

Mean 

SD 

Mean pain score (0 no pain to 100 maximum pain) Day 1  

50.1 

24.8 

44.2 

21.4 

5.9 

-498.2 to 51.0 

Mean pain score (0 no pain to 100 maximum pain) Day 2 

32.4 

20.8 

27.8 

21.7 

4.6 

-419.9 to 429.1 

Comments: 
1, Abstract and limited translation only - full translation of the paper would be welcome! 
2. Small measured benefits from hyperbaric oxygen cannot be ruled out in this underpowered study.  

Appraised by: Mike Bennett m.bennett@unsw.edu.au; Wednesday, 5 February 2020 
Kill or Update By: February 2021  

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