Svalestad
Hyperbaric oxygen therapy increases vascularity of the oral mucosa following radiotherapy
|
1. A course of HBOT increases the vascularity of the superficial mucosa following radiotherapy. |
Citation/s:1. Svalestad J, Hellem S, Thorsen E, Johannessen AC. Effect of hyperbaric oxygen treatment on irradiated oral mucosa: microvessel density. International journal of oral and maxillofacial surgery. 2015 Mar 31;44(3):301-7.
Lead author's name and fax: J Svalestad: Jarle.Svalestad@iko.uib.no
Three-part Clinical Question:For patients having received radiotherapy to the oral mucosa, what is the effect of a course of hyperbaric oxygen, compared to no HBOT, on the density of the microvasculature?
Search Terms: Radiotherapy, microvasculature, late radiation tissue injury
The Study:
Non-blinded concealed randomised controlled trial with intention-to-treat.
The Study Patients: Adult patients previoulsy treated for head and neck cancers with radiotherapy (50 to 70 centigray, 3 to 6 years ago).
Control group (N = 20; 18 analysed): No specific intervention
Experimental group (N = 20; 20 analysed): 100% oxygen breathing at 2.4 ATA daily for 90 minutes, average number 29 treatments.
The Evidence:
|
Measure |
Control Group |
HBO group |
Difference |
95%CI | ||
|
Microvessel density subepidermis (vessels/mm2) |
49.3 |
10.5 |
98 |
15.9 |
48.7 |
39.7 to 57.7 |
|
Microvessel density connective tiss. (vessels/mm2) |
34.4 |
7.8 |
45.1 |
16.4 |
10.7 |
2.1 to 19.3 |
|
Microvascular area (%) |
1.6 |
0.5 |
4.4 |
1.9 |
2.8 |
1.9 to 3.7 |
Comments:
1. Small study that nevertheless found significant improvement in vascularity in the superficial oral mucosa deeper connective tissue.
2. Patients were being treated for xerostomia, prophylaxis and ORN
3. No significant changes in cellularity or propensity to proliferate – taken as supporting the notion that HBO does not carry an increased chance of recurrence
Appraised by: M Bennett: m.bennett@unsw.edu.au ; Monday, 8 July 2019
Kill or Update By: July 2022
