Xiong

Hyperbaric oxygen for term newborns with hypoxic ischemic encephalopathy

Protocol for a Cochrane Systematic Review The objective of this review is to determine the effects of therapeutic HBO (with or without hypothermia) on death and long-term neurodevelopmental disabilities in term newborn infants with HIE. Furthermore, the short-term medical effects and side effects of HBO will be studied.

• • This protocol published in 2017 and no sign of the completed review.

Primary comparisons:

1. HBO versus supportive care;
2. HBO versus hypothermia therapy;
3. HBO plus hypothermia versus hypothermia alone;
4. HBO plus erythropoietin versus erythropoietin alone.

Subgroup analyses were planned on the basis of:

1. severity of HIE (mild, moderate, severe)
2. the therapeutic time window, by timing of commencement of the intervention (< 6 hours versus 6 hours to 7 days versus > 7 days);
3. the peak pressure of HBO (< 2 ATA versus > 2ATA);
4. the number of courses of HBO (single course versus multiple courses).

Citation Xiong T, Li H, Zhao J, Dong W, Qu Y, Wu T, Mu D. Hyperbaric oxygen for term newborns with hypoxic ischemic encephalopathy (Protocol). Cochrane Database of Systematic Reviews 2011, Issue 8. Art. No.: CD009248. DOI: 10.1002/14651858.CD009248.

BACK