Yuan 2010

Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function

Clinical bottom line:

1. Erectile function scores declined less following postoperative HBOT than a sham treatment.

Citation/s: 1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761


Lead author's name:Yang: yang_louyan@yahoo.cn

Three-part Clinical Question: Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.

Search Terms: erectile dysfunction. urethral reconstruction, urethral stricture

 

The Study: Double blinded, pseudo-randomised trial (alternate allocation) with intention-to-treat.

The Study Patients: Men with posterior urethral stricture and having operative reconstruction.

Control group: (N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.

Experimental group: (N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.

The Evidence:

Measure

Air Group

HBOT group

Difference

95% CI

 

Mean

SD

Mean

SD

   

Total IIEF* scores at 3 months (score 0 worst - 70 best)

52.8

5.2

61.3

4.1

-8.5

-12.4 to -4.6

Erectile function domain at 3 months (0 - 25)

19.5

2.9

23.8

1.9

-4.3

-6.3 to -2.2

  • IIEF = International Index of Erectile Function


 

Comments:

1. Not truly randomized. Alternate allocation following reconstruction.

2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts).

3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores.

4. Unpressurized sham - not known if this was effective.

5. Only a three month study. Long term effects not known.

 

Appraised by::'M Bennett m.bennett@unsw.edu.au ;    Friday, 16 January 2015

Kill or Update By:J uly 2021

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