Difference between revisions of "Yuan 2010"
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'''Citation/s: '''1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761 | '''Citation/s: '''1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761 | ||
| − | '''Lead author's name''':'''Yang: yang_louyan@yahoo.cn | + | '''Lead author's name''':'''Yang: yang_louyan@yahoo.cn''' |
| − | '''Three-part Clinical Question:''''''Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction. | + | '''Three-part Clinical Question:''''''Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.'' |
| − | '''Search Terms:''''''''''''erectile dysfunction. urethral reconstruction, urethral stricture | + | '''Search Terms:''''''''''''erectile dysfunction. urethral reconstruction, urethral stricture'' |
| | ||
| − | '''The Study: | + | '''The Study: '''Double blinded, pseudo-randomised trial (alternate allocation) with intention-to-treat. |
| | ||
| − | + | T'''he Study Patients: '''Men with posterior urethral stricture and having operative reconstruction. | |
| − | '''Control group | + | '''Control group: '''(N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group. |
| − | + | <span style="line-height: 1.5;">'''Experimental group:''' </span><span style="line-height: 1.5;">(N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.</span> | |
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| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Measure</span></span>'''</span> |
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | | style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | ||
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Air Group</span></span>'''</span> |
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | | style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | ||
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">HBOT group</span></span>'''</span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Difference</span></span>'''</span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:">95% CI</span></span>'''</span> |
|- | |- | ||
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">^</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Mean</span></span>'''</span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">SD</span></span>'''</span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Mean</span></span>'''</span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">SD</span></span>'''</span> |
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | | style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | | ||
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|- | |- | ||
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Total IIEF* scores at 3 months (score 0 worst - 70 best)</span></span>'''</span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">52.8</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">5.2</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">61.3</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">4.1</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">-8.5</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-12.4 to -4.6</span></span></span> |
|- | |- | ||
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">Erectile function domain at 3 months (0 - 25)</span></span>'''</span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">19.5</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">2.9</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">23.8</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">1.9</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:">-4.3</span></span></span> |
| style="border:solid windowtext 1.0pt" | | | style="border:solid windowtext 1.0pt" | | ||
| − | <span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family: | + | <span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:">-6.3 to -2.2</span></span></span> |
|} | |} | ||
| − | *IIEF = International Index of Erectile Function | + | *IIEF = International Index of Erectile Function |
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| − | '''Appraised by''''''''':''''''M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015 | + | '''Appraised by''''''''':''''''M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015''' |
| − | <span style="line-height: 1.5;">Kill or Update By:</span>'''<span style="line-height: 1.5;">July 2021</span> | + | '''<span style="line-height: 1.5;">Kill or Update By:</span>'''<span style="line-height: 1.5;">July 2021</span> |
[[File:Sumhorsa.gif|center|Sumhorsa.gif]] | [[File:Sumhorsa.gif|center|Sumhorsa.gif]] | ||
<span style="display: block; text-align: center;"><span style="font-size: 230%;">[[Flaps_and_grafts|BACK]]</span></span> | <span style="display: block; text-align: center;"><span style="font-size: 230%;">[[Flaps_and_grafts|BACK]]</span></span> | ||
Revision as of 02:10, 22 July 2019
Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function
Clinical bottom line:
| 1. Erectile function scores declined less following postoperative HBOT than a sham treatment. |
Citation/s: 1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761
Lead author's name:Yang: yang_louyan@yahoo.cn
Three-part Clinical Question:'Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.
Search Terms:'''''''erectile dysfunction. urethral reconstruction, urethral stricture
The Study: Double blinded, pseudo-randomised trial (alternate allocation) with intention-to-treat.
The Study Patients: Men with posterior urethral stricture and having operative reconstruction.
Control group: (N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.
Experimental group: (N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.
The Evidence:
|
Measure |
Air Group |
HBOT group |
Difference |
95% CI | ||
|
^ |
Mean |
SD |
Mean |
SD |
||
|
Total IIEF* scores at 3 months (score 0 worst - 70 best) |
52.8 |
5.2 |
61.3 |
4.1 |
-8.5 |
-12.4 to -4.6 |
|
Erectile function domain at 3 months (0 - 25) |
19.5 |
2.9 |
23.8 |
1.9 |
-4.3 |
-6.3 to -2.2 |
- IIEF = International Index of Erectile Function
Comments:
1. Not truly randomized. Alternate allocation following reconstruction.
2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts).
3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores.
4. Unpressurized sham - not known if this was effective.
5. Only a three month study. Long term effects not known.
Appraised by'''':'M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015
Kill or Update By:July 2021
