Difference between revisions of "Hoffman3"

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'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">No evidence of efficacy for hyperbaric oxygen in acute hearing loss or tinnitus of long-standing.</span>'''
 
  
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<span style="border-color: windowtext; border-style: solid; border-width: 2.25pt; display: block; padding: 7pt 0cm 6pt 3pt;">
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'''<span style="font-size:18.0pt"><span style="line-height:107%">No evidence of efficacy for hyperbaric oxygen in acute hearing loss or tinnitus of long-standing.</span></span>'''
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<span style="padding-bottom: 0cm; padding-left: 0cm; padding-right: 0cm; padding-top: 0cm;">'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Clinical Bottom Line:</span>'''
 
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<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">1.No evidence of improvement in hearing loss or tinnitus with the administration of hyperbaric oxygen.
 
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2.Pressurization was associated with some benefit in both groups.</span></span>
 
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</span>
 
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**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Appraised by:</span>'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;"> Mike Bennett, Dept. of Diving and Hyperbaric Medicine, Prince of Wales Hospital</span>
 
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<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Sydney; Wednesday, 28 July 1999</span>
 
  
−
**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Clinical Scenario:</span>'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;"> A patient with long-standing hearing loss and tinnitus presented for treatment and we wondered if there was any place for hyperbaric oxygen. </span>
+
'''<span style="font-size:14.0pt"><span style="line-height:107%">Clinical Bottom Line:</span></span>'''
−
**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Three-part Question:</span>'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;"> For patients with hearing loss and/or tinnitus of acute onset, where the loss is of long standing (>6 months), does the application of hyperbaric oxygen, compared to placebo, result in any improvement in hearing loss or tinnitus?</span>
 
−
**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Search Terms:</span>'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;"> Hyperbaric oxygen, deafness, tinnitus</span>
 
  
−
**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">The Study:</span>'''
+
<span style="font-size:14.0pt"><span style="line-height:107%">1. No evidence of improvement in hearing loss or tinnitus with the administration of hyperbaric oxygen.</span></span>
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Double-blinded randomised controlled trial with intention-to-treat.</span>
 
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Patients with a history of sudden onset of inner-ear hearing loss and/or tinnitus lasting at least 6 months. </span>
 
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Control group (N = 22; 22 analysed): Air breathing at 1.5ATA for 45 minutes daily, five days each week for 3 weeks.</span>
 
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Experimental group (N = 22; 22 analysed): 100% oxygen breathing at 1.5ATA on the same schedule as controls.</span>
 
  
−
**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">The Evidence:</span>'''
+
<span style="font-size:14.0pt"><span style="line-height:107%">&nbsp;2. Pressurization was associated with some benefit in both groups.</span></span>
−
{|
+
 
−
| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">Outcome</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">Time to Outcome</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">Control group</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">HBO group</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">Relative risk reduction</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">Absolute risk reduction</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">NNT</span>'''</span></span>  
+
----
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Citation/s:</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">1. Hoffmann G, Bohmer D, Desloovere C. Hyperbaric oxygen as a treatment of chronic forms of inner ear hearing loss and tinnitus.In: Wen-ren Li. Proceedings of the Eleventh International Congress of Hyperbaric Medicine, Fuzhou, China. Best Publishing, Flagstaff, Arizona 1993:141-145.</span></span>
 +
 
 +
&nbsp;
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Clinical Scenario:</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">A patient with long-standing hearing loss and tinnitus presented for treatment and we wondered if there was any place for hyperbaric oxygen.</span></span>
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Three-part Question:</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">For patients with hearing loss and/or tinnitus of acute onset, where the loss is of long standing (>6 months), does the application of hyperbaric oxygen, compared to placebo, result in any improvement in hearing loss or tinnitus?</span></span>
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Search Terms:</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">Hyperbaric oxygen, deafness, tinnitus</span></span>
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">The Study:</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">Double-blinded randomised controlled trial with intention-to-treat. Patients with a history of sudden onset of inner-ear hearing loss and/or tinnitus lasting at least 6 months.</span></span>
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Control group (N = 22; 22 analysed):</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">Air breathing at 1.5ATA for 45 minutes daily, five days each week for 3 weeks.</span></span>
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Experimental group (N = 22; 22 analysed):</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">100% oxygen breathing at 1.5ATA on the same schedule as controls.</span></span>
 +
 
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">The Evidence:</span></span>'''
 +
 
 +
{| class="Table" style="border:solid windowtext 1.0pt"
 
|-
 
|-
−
| '''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">Improved hearing</span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">3 weeks</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">0.5</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">0.33</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">34%</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">0.17</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">6</span></span>  
+
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''<span style="font-size:12.0pt"><span style="line-height:107%">Outcome</span></span>'''</p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''<span style="font-size:12.0pt"><span style="line-height:107%">Time to Outcome</span></span>'''</p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''<span style="font-size:12.0pt"><span style="line-height:107%">Control group</span></span>'''</p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''<span style="font-size:12.0pt"><span style="line-height:107%">HBO group</span></span>'''</p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''<span style="font-size:12.0pt"><span style="line-height:107%">Relative risk reduction</span></span>'''</p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''<span style="font-size:12.0pt"><span style="line-height:107%">Absolute risk reduction</span></span>'''</p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt">'''<span style="font-size:12.0pt"><span style="line-height:107%">NNT</span></span>'''</p>  
 
|-
 
|-
−
| '''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">95% CI:</span>''' ||  ||  ||  || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">-23% to 91%</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">-0.12 to 0.46</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">NNT'''2 to INF NNH=9 to INF</span></span>  
+
| rowspan="2" style="border:solid windowtext 1.0pt" |
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Improved hearing</span></span>'''
 +
 
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">3 weeks</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">0.5</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">0.33</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">34%</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">0.17</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">6</span></span></p>  
 
|-
 
|-
−
| '''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">Improved tinnitus</span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">3 weeks</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">0.41</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">0.18</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">56%</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">0.23</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">4</span></span>  
+
| colspan="3" style="border:solid windowtext 1.0pt" | <p align="right" style="text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">95% CI:</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">-23% to 91%</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">-0.12 to 0.46</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">NNT2 to INF</span></span></p> <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">NNH=9 to INF</span></span></p>  
 
|-
 
|-
−
| '''<span style'''"font-family: &#39;Times New Roman&#39;,&#39;serif&#39;;">95% CI:</span>''' ||  ||  ||  || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">-8% to 100%</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">-0.03 to 0.49</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-family: &quot;Times New Roman&quot;,serif; text-align: center;">NNT'''2 to INF NNH=32 to INF</span></span>  
+
| rowspan="2" style="border:solid windowtext 1.0pt" |
 +
'''<span style="font-size:12.0pt"><span style="line-height:107%">Improved tinnitus</span></span>'''
 +
 
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">3 weeks</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">0.41</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">0.18</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">56%</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">0.23</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">4</span></span></p>  
 
|-
 
|-
 +
| colspan="3" style="border:solid windowtext 1.0pt" | <p align="right" style="text-align:right; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">95% CI:</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">-8% to 100%</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">-0.03 to 0.49</span></span></p>
 +
| style="border:solid windowtext 1.0pt" | <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">NNT2 to INF</span></span></p> <p align="center" style="text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="font-size:12.0pt"><span style="line-height:107%">NNH=32 to INF</span></span></p>
 
|}
 
|}
  
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">'''Comments:'''</span>
+
&nbsp;
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">1. Control group was pressurized and breathed an increased PO2. Any benefit may be due to a placebo effect, pressure effect or oxygen effect (equivalent 31.5% oxygen at 1ATA).</span>
+
 
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">2. All patients received a second course of hyperbaric oxygen at 1.5ATA immediately following the trial course, making longer-term follow-up impossible.</span>
+
'''<span style="font-size:12.0pt"><span style="line-height:107%">Comments:</span></span>'''
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">3. 15 treatments may have been insufficient in this chronic, well-established condition.</span>
+
 
 +
<span style="font-size:12.0pt"><span style="line-height:107%">1. Control group was pressurized and breathed an increased PO<sub>2</sub>. Any benefit may be due to a placebo effect, pressure effect or oxygen effect (equivalent 31.5% oxygen at 1ATA).</span></span>
 +
 
 +
<span style="font-size:12.0pt"><span style="line-height:107%">2. All patients received a second course of hyperbaric oxygen at 1.5ATA immediately following the trial course, making comparative longer-term follow-up impossible.</span></span>
 +
 
 +
<span style="font-size:12.0pt"><span style="line-height:107%">3. 15 treatments may have been insufficient in this chronic, well-established condition.</span></span>
 +
 
 +
&nbsp;
  
−
**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">Expiry date:</span>'''<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;"> June 2020</span>
+
'''<span style="font-size:12.0pt"><span style="line-height:107%">Appraised by:</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">Mike Bennett, Dept. of Diving and Hyperbaric Medicine, Prince of Wales Hospital,</span></span><span style="font-size:12.0pt"><span style="line-height:107%">Sydney; Wednesday, 28 July 1999</span></span>
−
**<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">References: </span>'''
 
−
<span style="font-family: &#39;Times New Roman&#39;,&#39;serif&#39;; font-size: 16px;">1. Hoffmann G, Bohmer D, Desloovere C. Hyperbaric oxygen as a treatment of chronic forms of inner ear hearing loss and tinnitus.In: Wen-ren Li. Proceedings of the Eleventh International Congress of Hyperbaric Medicine, Fuzhou, China. Best Publishing, Flagstaff, Arizona 1993:141-145.</span>
 
  
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[[File:sumhorsa.gif|center]]
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'''<span style="font-size:12.0pt"><span style="line-height:107%">Expiry date:</span></span>'''<span style="font-size:12.0pt"><span style="line-height:107%">June 2022</span></span>
  
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[[File:Sumhorsa.gif|center|Sumhorsa.gif]]
  
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&nbsp;
  
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<span style="display: block; text-align: center;"><span style="font-size: 29.9px;">[[Audiovestibular | BACK]]</span></span>
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<span style="display: block; text-align: center;"><span style="font-size: 29.9px;">[[Audiovestibular|BACK]]</span></span>

Latest revision as of 00:59, 5 October 2021

No evidence of efficacy for hyperbaric oxygen in acute hearing loss or tinnitus of long-standing.

Clinical Bottom Line:

1. No evidence of improvement in hearing loss or tinnitus with the administration of hyperbaric oxygen.

 2. Pressurization was associated with some benefit in both groups.

Citation/s:1. Hoffmann G, Bohmer D, Desloovere C. Hyperbaric oxygen as a treatment of chronic forms of inner ear hearing loss and tinnitus.In: Wen-ren Li. Proceedings of the Eleventh International Congress of Hyperbaric Medicine, Fuzhou, China. Best Publishing, Flagstaff, Arizona 1993:141-145.

 

Clinical Scenario:A patient with long-standing hearing loss and tinnitus presented for treatment and we wondered if there was any place for hyperbaric oxygen.

Three-part Question:For patients with hearing loss and/or tinnitus of acute onset, where the loss is of long standing (>6 months), does the application of hyperbaric oxygen, compared to placebo, result in any improvement in hearing loss or tinnitus?

Search Terms:Hyperbaric oxygen, deafness, tinnitus

The Study:Double-blinded randomised controlled trial with intention-to-treat. Patients with a history of sudden onset of inner-ear hearing loss and/or tinnitus lasting at least 6 months.

Control group (N = 22; 22 analysed):Air breathing at 1.5ATA for 45 minutes daily, five days each week for 3 weeks.

Experimental group (N = 22; 22 analysed):100% oxygen breathing at 1.5ATA on the same schedule as controls.

The Evidence:

Outcome

Time to Outcome

Control group

HBO group

Relative risk reduction

Absolute risk reduction

NNT

Improved hearing

3 weeks

0.5

0.33

34%

0.17

6

95% CI:

-23% to 91%

-0.12 to 0.46

NNT2 to INF

NNH=9 to INF

Improved tinnitus

3 weeks

0.41

0.18

56%

0.23

4

95% CI:

-8% to 100%

-0.03 to 0.49

NNT2 to INF

NNH=32 to INF

 

Comments:

1. Control group was pressurized and breathed an increased PO2. Any benefit may be due to a placebo effect, pressure effect or oxygen effect (equivalent 31.5% oxygen at 1ATA).

2. All patients received a second course of hyperbaric oxygen at 1.5ATA immediately following the trial course, making comparative longer-term follow-up impossible.

3. 15 treatments may have been insufficient in this chronic, well-established condition.

 

Appraised by:Mike Bennett, Dept. of Diving and Hyperbaric Medicine, Prince of Wales Hospital,Sydney; Wednesday, 28 July 1999

Expiry date:June 2022

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