Difference between revisions of "Hadanny"
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| − | <span style="line-height:normal">'''<span style="font-size:18pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:18pt"><span style="font-family:">Intervention with hyperbaric oxygen was associated with improved cognition compared to doing nothing</span></span>'''</span> |
| − | <span style="line-height:normal">'''<span style="font-size:14pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:14pt"><span style="font-family:">Clinical bottom line:</span></span>'''</span> |
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| − | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family: | + | <span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:">1. HBO group improved in some outcomes during the study period but this was not seen in the no contact group. May be a participation effect.<br/> 2. No evidence of significant between group differences after treatment period.</span></span>'''</span> |
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| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">Citation/s:</span>'''<span style="font-family:">1.</span>'''<span style="font-family:">Hadanny A, Malka D, Gil S, Rahav B-G, Merav C, Kobi D, Hachmo Y, Ramzia AH, Fishlev G, Lang E, Polak N, Keren D, Friedman M, Sigal T, Yonatan Z, Bechor Y, Efrati S Cognitive enhancement of healthy older adults with hyperbaric oxygen: A randomized controlled trial. Ageing 2020;12(13):13740</span>'''<br/> Lead author's name and fax: '''Amir Hadanny email: amir.had@gmail.com'''</span> |
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">Three-part Clinical Question:</span>'''<span style="font-family:">For healthy individuals older than 63, does a course of hyperbaric oxygen, compared to no treatment, result in any cognitive enhancement?<br/> '''Search Terms:''' Ageing; dementia; cognition</span></span> |
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">The Study:</span>'''<span style="font-family:">Non-blinded randomised controlled trial without intention-to-treat.<br/> '''The Study Patients:''' Healthy individuals aged >63 years.<br/> '''Control group''' (N = 35 ; 32 analysed): No intervention or contact.<br/> '''Experimental group''' (N = 35 ; 29 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily (Mon to Fri) to a total of 60 sessions.</span></span> |
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">The Evidence:</span>'''</span> |
{| class="Table" style="border:solid windowtext 1.0pt" | {| class="Table" style="border:solid windowtext 1.0pt" | ||
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| − | | rowspan="2" style="width:118.0pt; border:solid windowtext 1.0pt" width="160" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | rowspan="2" style="width:118.0pt; border:solid windowtext 1.0pt" width="160" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">Measure</span>'''</span></p> |
| − | | colspan="2" style="width:104.9pt; border:solid windowtext 1.0pt" width="142" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | colspan="2" style="width:104.9pt; border:solid windowtext 1.0pt" width="142" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">No contact group</span>'''</span></p> |
| − | | colspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | colspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">HBOT Group</span>'''</span></p> |
| − | | rowspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | rowspan="2" style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">Difference</span>'''</span></p> |
| − | | rowspan="2" style="width:84.4pt; border:solid windowtext 1.0pt" width="116" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | rowspan="2" style="width:84.4pt; border:solid windowtext 1.0pt" width="116" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">95% CI</span>'''</span></p> |
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| − | | style="width:67.5pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | style="width:67.5pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">Mean</span>'''</span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">SD</span>'''</span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">Mean</span>'''</span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal">'''<span style="font-family:">SD</span>'''</span></p> |
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| style="width:118.0pt; border:solid windowtext 1.0pt" width="160" | | | style="width:118.0pt; border:solid windowtext 1.0pt" width="160" | | ||
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">Global cognitive score</span>'''</span> |
| − | | style="width:67.5pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="width:67.5pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">103</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">8.3</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">110.6</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">6.8</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">7.6</span></span></p> |
| − | | style="width:84.4pt; border:solid windowtext 1.0pt" width="116" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="width:84.4pt; border:solid windowtext 1.0pt" width="116" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">-22.0 to 37.1</span></span></p> |
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| style="width:118.0pt; border:solid windowtext 1.0pt" width="160" | | | style="width:118.0pt; border:solid windowtext 1.0pt" width="160" | | ||
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">Executive function percentile</span>'''</span> |
| − | | style="width:67.5pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="width:67.5pt; border:solid windowtext 1.0pt" width="92" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">73.4</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">29.3</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">88.3</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">16.8</span></span></p> |
| − | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="border:solid windowtext 1.0pt" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">14.9</span></span></p> |
| − | | style="width:84.4pt; border:solid windowtext 1.0pt" width="116" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family: | + | | style="width:84.4pt; border:solid windowtext 1.0pt" width="116" | <p align="center" style="margin-bottom:.0001pt; text-align:center; padding:.75pt .75pt .75pt .75pt"><span style="line-height:normal"><span style="font-family:">-285.2 to 315.0</span></span></p> |
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| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">Comments:</span>'''<br/> <span style="font-family:">1. Study based on the association of ageing with both cognitive decline and falling regional cerebral blood flow. Authors assume cause and effect in operation.<br/> 2. 30 of 100 individuals contacted did not participate and nine of the remaining 70 were not included in results.<br/> 3. Short-term outcome at end of treatment period only. Long course of hyperbaric – 60 treatments. Not clear how this was chosen. It is not clear what min and max scores are possible from the outcome measures used (commercial tools).<br/> 4. No between-group comparisons are given, only the findings within each group. Some baseline differences between groups might be important (e.g. executive function 64.9 (control) versus 70 (HBO)).. Sample size based on five point improvement in cognitive function with HBOT versus 2 points in control. It is not clear the authors have tested for this differnce. They used a group by time interaction test rather thana simple comparison of means as suggested in their analysis plan.</span></span> |
| − | <span style="line-height:normal">'''<span style="font-family: | + | <span style="line-height:normal">'''<span style="font-family:">Appraised by:</span>'''<span style="font-family:">Mike Bennett m.bennett@unsw.edu.au; Thursday, 1 April 2021</span></span><br/> '''<span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:">Kill or Update By:</span></span></span>'''<span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:">April 2024</span></span></span> |
| − | '''<span style="font-size:11pt"><span style="line-height:107%"><span style="font-family: | + | <p style="text-align: center;"> </p> <p style="text-align: center;">[[File:Sumhorsa.gif|center|Sumhorsa.gif]]</p> <p style="text-align: center;"><span style="font-size:xx-large;">[[Neuro_-_miscellaneous|BACK]]</span></p> |
Latest revision as of 00:25, 1 April 2021
Intervention with hyperbaric oxygen was associated with improved cognition compared to doing nothing
Clinical bottom line:
|
1. HBO group improved in some outcomes during the study period but this was not seen in the no contact group. May be a participation effect. |
Citation/s:1.Hadanny A, Malka D, Gil S, Rahav B-G, Merav C, Kobi D, Hachmo Y, Ramzia AH, Fishlev G, Lang E, Polak N, Keren D, Friedman M, Sigal T, Yonatan Z, Bechor Y, Efrati S Cognitive enhancement of healthy older adults with hyperbaric oxygen: A randomized controlled trial. Ageing 2020;12(13):13740
Lead author's name and fax: Amir Hadanny email: amir.had@gmail.com
Three-part Clinical Question:For healthy individuals older than 63, does a course of hyperbaric oxygen, compared to no treatment, result in any cognitive enhancement?
Search Terms: Ageing; dementia; cognition
The Study:Non-blinded randomised controlled trial without intention-to-treat.
The Study Patients: Healthy individuals aged >63 years.
Control group (N = 35 ; 32 analysed): No intervention or contact.
Experimental group (N = 35 ; 29 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily (Mon to Fri) to a total of 60 sessions.
The Evidence:
Measure |
No contact group |
HBOT Group |
Difference |
95% CI | ||
Mean |
SD |
Mean |
SD | |||
|
Global cognitive score |
103 |
8.3 |
110.6 |
6.8 |
7.6 |
-22.0 to 37.1 |
|
Executive function percentile |
73.4 |
29.3 |
88.3 |
16.8 |
14.9 |
-285.2 to 315.0 |
Comments:
1. Study based on the association of ageing with both cognitive decline and falling regional cerebral blood flow. Authors assume cause and effect in operation.
2. 30 of 100 individuals contacted did not participate and nine of the remaining 70 were not included in results.
3. Short-term outcome at end of treatment period only. Long course of hyperbaric – 60 treatments. Not clear how this was chosen. It is not clear what min and max scores are possible from the outcome measures used (commercial tools).
4. No between-group comparisons are given, only the findings within each group. Some baseline differences between groups might be important (e.g. executive function 64.9 (control) versus 70 (HBO)).. Sample size based on five point improvement in cognitive function with HBOT versus 2 points in control. It is not clear the authors have tested for this differnce. They used a group by time interaction test rather thana simple comparison of means as suggested in their analysis plan.
Appraised by:Mike Bennett m.bennett@unsw.edu.au; Thursday, 1 April 2021
Kill or Update By:April 2024
