Difference between revisions of "Yuan 2010"

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==<span style="font-size: 16pt;">Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function</span>==
 
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===<span style="font-size: 14pt;">Clinical bottom line:</span>===
 
  
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{|  
+
== <span style="font-size:x-large;">Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function</span> ==
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| '''1. Erectile function scores declined less following postoperative HBOT than a sham treatment.'''
+
 
 +
=== <span style="font-size: 14pt;">Clinical bottom line:</span> ===
 +
 
 +
{|
 
|-
 
|-
 +
| '''1. Erectile function scores declined less following postoperative HBOT than a sham treatment.'''
 
|}
 
|}
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**Citation/s:'''
 
−
1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761
 
  
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**Lead author's name and fax:''' Yang: yang_louyan@yahoo.cn
+
'''Citation/s:&nbsp;'''1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761
−
**Three-part Clinical Question:''' Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.
+
 
 +
'''Lead author's name''':'''Yang: yang_louyan@yahoo.cn
 +
 
 +
'''Three-part Clinical Question:''''''Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.
 +
 
 +
'''Search Terms:''''''''''''erectile dysfunction. urethral reconstruction, urethral stricture
 +
 
 +
&nbsp;
 +
 
 +
'''The Study:'''''''''Double-blinded pseudo-randomised trial (alternate allocation) with intention-to-treat.'''
 +
 
 +
&nbsp;
 +
 
 +
The Study Patients:'''Men with posterior urethral stricture and having operative reconstruction.
 +
 
 +
'''Control group''''''(N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.
  
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**Search Terms:''' erectile dysfunction. urethral reconstruction, urethral stricture
+
'''<span style="line-height: 1.5;">Experimental group</span>''''''<span style="line-height: 1.5;"></span>'''<span style="line-height: 1.5;">(N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.</span>
−
**The Study:''' Double-blinded pseudo-randomised trial (alternate allocation) with intention-to-treat.
 
  
−
**The Study Patients:''' Men with posterior urethral stricture and having operative reconstruction.
+
&nbsp;
−
**Control group''' (N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.
 
−
**<span style="line-height: 1.5;">Experimental group</span>'''<span style="line-height: 1.5;"> (N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.</span>
 
  
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**The Evidence:'''
+
&nbsp;
−
{|
+
 
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| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Measure</span>'''</span></span> |||| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Air Group</span>'''</span></span> |||| <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">HBOT group</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Difference</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style="font-size: 10pt;">95% CI</span>'''</span></span>
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'''The Evidence:'''
 +
 
 +
{| class="Table" style="border:solid windowtext 1.0pt"
 
|-
 
|-
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|^  || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Mean</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">SD</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">Mean</span>'''</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; text-align: center;">'''<span style'''"font-size: 10pt;">SD</span>'''</span></span> ||  || 
+
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Measure</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | &nbsp;
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Air Group</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | &nbsp;
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">HBOT group</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Difference</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal">'''<span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">95% CI</span></span>'''</span>
 +
 
 
|-
 
|-
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| '''<span style'''"font-size: 10pt;">Total IIEF* scores at 3 months (score 0 worst - 70 best) </span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">52.8</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">5.2</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">61.3</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">4.1</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">-8.5</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-size: 10pt; text-align: center;">-12.4 to -4.6</span></span>
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| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">^</span></span></span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Mean</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">SD</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Mean</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">SD</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | &nbsp;
 +
| style="border:solid windowtext 1.0pt; padding:.75pt .75pt .75pt .75pt" | &nbsp;
 
|-
 
|-
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| '''<span style'''"font-size: 10pt;">Erectile function domain at 3 months (0 - 25)</span>''' || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">19.5</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">2.9</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">23.8</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">1.9</span></span> || <span style'''"display: block; text-align: center;"><span style'''"display: block; font-size: 10pt; text-align: center;">-4.3</span></span> || <span style'''"display: block; text-align: center;"><span style="display: block; font-size: 10pt; text-align: center;">-6.3 to -2.2</span></span>  
+
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Total IIEF* scores at 3 months (score 0 worst - 70 best)</span></span>'''</span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">52.8</span></span></span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">5.2</span></span></span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">61.3</span></span></span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">4.1</span></span></span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">-8.5</span></span></span>
 +
 
 +
| style="border:solid windowtext 1.0pt" |  
 +
<span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-12.4 to -4.6</span></span></span>
 +
 
 
|-
 
|-
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal">'''<span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">Erectile function domain at 3 months (0 - 25)</span></span>'''</span>
 +
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">19.5</span></span></span>
 +
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">2.9</span></span></span>
 +
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">23.8</span></span></span>
 +
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">1.9</span></span></span>
 +
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal"><span style="font-size:12.0pt"><span style="font-family:" times="" new="" roman",serif"="">-4.3</span></span></span>
 +
 +
| style="border:solid windowtext 1.0pt" |
 +
<span style="line-height:normal"><span style="font-size:10.0pt"><span style="font-family:" times="" new="" roman",serif"="">-6.3 to -2.2</span></span></span>
 +
 
|}
 
|}
−
<span style="line-height: 1.5;">*IIEF = International Index of Erectile Function</span>
 
  
−
**Comments:'''
+
*IIEF = International Index of Erectile Function
 +
 
 +
&nbsp;
 +
 
 +
'''Comments:'''
 +
 
 
1. Not truly randomized. Alternate allocation following reconstruction.
 
1. Not truly randomized. Alternate allocation following reconstruction.
 +
 
2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts).
 
2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts).
 +
 
3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores.
 
3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores.
 +
 
4. Unpressurized sham - not known if this was effective.
 
4. Unpressurized sham - not known if this was effective.
 +
 
5. Only a three month study. Long term effects not known.
 
5. Only a three month study. Long term effects not known.
  
−
**Appraised by''': M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015
+
&nbsp;
 +
 
 +
&nbsp;
 +
 
 +
'''Appraised by''''''''':''''''M Bennett m.bennett@unsw.edu.au&nbsp;; Friday, 16 January 2015
  
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**<span style="line-height: 1.5;">Kill or Update By:</span>'''<span style="line-height: 1.5;"> July 2021</span>
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<span style="line-height: 1.5;">Kill or Update By:</span>'''<span style="line-height: 1.5;">July 2021</span>'''
  
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[[File:sumhorsa.gif|center]]
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[[File:Sumhorsa.gif|center|Sumhorsa.gif]]
  
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<span style="display: block; text-align: center;"><span style="font-size: 230%;">[[Flaps and grafts | BACK]]</span></span>
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<span style="display: block; text-align: center;"><span style="font-size: 230%;">[[Flaps_and_grafts|BACK]]</span></span>

Revision as of 02:07, 22 July 2019

Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function

Clinical bottom line:

1. Erectile function scores declined less following postoperative HBOT than a sham treatment.

Citation/s: 1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761

Lead author's name:Yang: yang_louyan@yahoo.cn

Three-part Clinical Question:'Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.

Search Terms:'''''''erectile dysfunction. urethral reconstruction, urethral stricture

 

'The Study:''''Double-blinded pseudo-randomised trial (alternate allocation) with intention-to-treat.

 

The Study Patients:Men with posterior urethral stricture and having operative reconstruction.

Control group'(N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.

'Experimental group'(N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.

 

 

The Evidence:

Measure

 

Air Group

 

HBOT group

Difference

95% CI

^

Mean

SD

Mean

SD

   

Total IIEF* scores at 3 months (score 0 worst - 70 best)

52.8

5.2

61.3

4.1

-8.5

-12.4 to -4.6

Erectile function domain at 3 months (0 - 25)

19.5

2.9

23.8

1.9

-4.3

-6.3 to -2.2

  • IIEF = International Index of Erectile Function

 

Comments:

1. Not truly randomized. Alternate allocation following reconstruction.

2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts).

3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores.

4. Unpressurized sham - not known if this was effective.

5. Only a three month study. Long term effects not known.

 

 

Appraised by'''':'M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015

Kill or Update By:July 2021

Sumhorsa.gif

BACK

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