Yuan 2010
Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function
Clinical bottom line:
| 1. Erectile function scores declined less following postoperative HBOT than a sham treatment. |
- Citation/s:
1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761
- Lead author's name and fax: Yang: yang_louyan@yahoo.cn
- Three-part Clinical Question: Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.
- Search Terms: erectile dysfunction. urethral reconstruction, urethral stricture
- The Study: Double-blinded pseudo-randomised trial (alternate allocation) with intention-to-treat.
- The Study Patients: Men with posterior urethral stricture and having operative reconstruction.
- Control group (N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.
- Experimental group (N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.
- The Evidence:
| Measure | Air Group | HBOT group | Difference | 95% CI | ||
| ^ | Mean | SD | Mean | SD | ||
| Total IIEF* scores at 3 months (score 0 worst - 70 best) | 52.8 | 5.2 | 61.3 | 4.1 | -8.5 | -12.4 to -4.6 |
| Erectile function domain at 3 months (0 - 25) | 19.5 | 2.9 | 23.8 | 1.9 | -4.3 | -6.3 to -2.2 |
*IIEF = International Index of Erectile Function
- Comments:
1. Not truly randomized. Alternate allocation following reconstruction. 2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts). 3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores. 4. Unpressurized sham - not known if this was effective. 5. Only a three month study. Long term effects not known.
- Appraised by: M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015
- Kill or Update By: July 2021
