Yuan 2010
Hyperbaric oxygen therapy following urethral reconstruction limited the decrease in erectile function
Clinical bottom line:
| 1. Erectile function scores declined less following postoperative HBOT than a sham treatment. |
Citation/s: 1. Yuan J-B, Yang L-Y, Wang Y-H, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction. International Urology Journal 2011; 43:755-761
Lead author's name:Yang: yang_louyan@yahoo.cn
Three-part Clinical Question:'Does hyperbaric oxygen promote the recovery of erectile function following posterior urethral reconstruction.
Search Terms:'''''''erectile dysfunction. urethral reconstruction, urethral stricture
The Study: Double blinded, pseudo-randomised trial (alternate allocation) with intention-to-treat.
The Study Patients: Men with posterior urethral stricture and having operative reconstruction.
Control group: (N = 12; 12 analysed): Placed in chamber and breathing air at 1 ATA on the same schedule as for HBOT group.
Experimental group: (N = 12; 12 analysed): 100% oxygen breathing at 2 ATA for 90 minutes daily postoperatively from the second postoperative day for a total of 14 treatments.
The Evidence:
|
Measure |
Air Group |
HBOT group |
Difference |
95% CI | ||
|
^ |
Mean |
SD |
Mean |
SD |
||
|
Total IIEF* scores at 3 months (score 0 worst - 70 best) |
52.8 |
5.2 |
61.3 |
4.1 |
-8.5 |
-12.4 to -4.6 |
|
Erectile function domain at 3 months (0 - 25) |
19.5 |
2.9 |
23.8 |
1.9 |
-4.3 |
-6.3 to -2.2 |
- IIEF = International Index of Erectile Function
Comments:
1. Not truly randomized. Alternate allocation following reconstruction.
2. Patients with EF scores less than 22 (any degree of dysfunction) pre-operatively were excluded (2 pts).
3. Erectile function scores were worse in both groups postoperatively, but on comparison, those who received HBOT had better scores.
4. Unpressurized sham - not known if this was effective.
5. Only a three month study. Long term effects not known.
Appraised by'''':'M Bennett m.bennett@unsw.edu.au ; Friday, 16 January 2015
Kill or Update By:July 2021
